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Journal of Autism and Developmental Disorders

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09-03-2021 | Original Paper

Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome

Auteurs: Scott S. Hall, Matthew J. Riley, Robyn N. Weston, Jean-Francois Lepage, David S. Hong, Booil Jo, Joachim Hallmayer, Allan L. Reiss

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2022

Abstract

Previous studies have suggested that girls with Turner syndrome (TS) exhibit symptoms of social anxiety during interactions with others. However, few studies have quantified these behaviors during naturalistic face-to-face social encounters. In this study, we coded observational markers of social anxiety in prepubertal girls with TS and age-matched controls during a 10-min social encounter with an unfamiliar examiner. Results showed that girls with TS exhibited significantly higher levels of gaze avoidance compared to controls. Impairments in social gaze were particularly increased in girls with a maternally retained X chromosome (Xm), suggesting a genomic imprinting effect. These data indicate that social gaze avoidance may be a critical behavioral marker for identifying early social dysfunction in young girls with TS.

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Titel: Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome
Auteurs: Scott S. Hall
Matthew J. Riley
Robyn N. Weston
Jean-Francois Lepage
David S. Hong
Booil Jo
Joachim Hallmayer
Allan L. Reiss
Publicatiedatum: 09-03-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-04896-y

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