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Gepubliceerd in: Journal of Autism and Developmental Disorders 11/2017

26-07-2017 | Original Paper

Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms

Auteurs: Kelly W. Sheppard, Kelly M. Boone, Barbara Gracious, Mark A. Klebanoff, Lynette K. Rogers, Joseph Rausch, Christopher Bartlett, Daniel L. Coury, Sarah A. Keim

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2017

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Abstract

Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD.
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Literatuur
go back to reference Ahmad, A., Moriguchi, T., & Salem, N. (2002a). Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatric Neurology, 26, 210–218. CrossRefPubMed Ahmad, A., Moriguchi, T., & Salem, N. (2002a). Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatric Neurology, 26, 210–218. CrossRefPubMed
go back to reference Aid, S., Vancassel, S., Poumes-Ballihaut, C., Chalon, S., Guesnet, P., & Lavialle, M. (2003). Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. Journal of Lipid Research, 44, 1545–1551. doi: 10.​1194/​jlr.​M300079-JLR200. CrossRefPubMed Aid, S., Vancassel, S., Poumes-Ballihaut, C., Chalon, S., Guesnet, P., & Lavialle, M. (2003). Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. Journal of Lipid Research, 44, 1545–1551. doi: 10.​1194/​jlr.​M300079-JLR200. CrossRefPubMed
go back to reference Pan, B.A., Rowe, M. L., Spier, E., & Tamis-Lemonda, C. (2004). Measuring productive vocabulary of toddlers in low-income families: Concurrent and predictive validity of three sources of data. Journal of Child Language, 31, 587–608. doi: 10.​1017/​s030500090400627​0. CrossRefPubMed Pan, B.A., Rowe, M. L., Spier, E., & Tamis-Lemonda, C. (2004). Measuring productive vocabulary of toddlers in low-income families: Concurrent and predictive validity of three sources of data. Journal of Child Language, 31, 587–608. doi: 10.​1017/​s030500090400627​0. CrossRefPubMed
go back to reference Arriaga, R. I., Fenson, L., Cronan, T., Pethick, S. J. (2008). Scores on the MacArthur Communicative Development Inventory of children from lowand middle-income families. Applied Psycholinguistics, 19, 209 doi: 10.​1017/​s014271640001004​3. CrossRef Arriaga, R. I., Fenson, L., Cronan, T., Pethick, S. J. (2008). Scores on the MacArthur Communicative Development Inventory of children from lowand middle-income families. Applied Psycholinguistics, 19, 209 doi: 10.​1017/​s014271640001004​3. CrossRef
go back to reference Bliss, T.V.P., & Collingridge, G. L. (1993). A synaptic model of memory: Long-term potentiation in the hippocampus. Nature, 361, 31–39. CrossRefPubMed Bliss, T.V.P., & Collingridge, G. L. (1993). A synaptic model of memory: Long-term potentiation in the hippocampus. Nature, 361, 31–39. CrossRefPubMed
go back to reference Bourre, J. M., et al. (1989). The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. Journal of Nutrition, 119, 1880–1892. PubMed Bourre, J. M., et al. (1989). The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. Journal of Nutrition, 119, 1880–1892. PubMed
go back to reference Bourre, J.M., et al. (1993). Function of dietary polyunsaturated fatty acids in nervous system. Prostaglandins, Leukotrienes and Essential Fatty Acids, 48, 5–15. CrossRef Bourre, J.M., et al. (1993). Function of dietary polyunsaturated fatty acids in nervous system. Prostaglandins, Leukotrienes and Essential Fatty Acids, 48, 5–15. CrossRef
go back to reference Breckenridge, W. C., Morgan, I. G., Zanetta, J. P., & Vincendon, G. (1973). Adult rat brain synaptic vesicles II. Lipid composition. Biochimica et Biophysica Acta, 320, 681–686. CrossRefPubMed Breckenridge, W. C., Morgan, I. G., Zanetta, J. P., & Vincendon, G. (1973). Adult rat brain synaptic vesicles II. Lipid composition. Biochimica et Biophysica Acta, 320, 681–686. CrossRefPubMed
go back to reference Bruckner, C., Yoder, P., Stone, W., & Saylor, M. (2007). Construct validity of the MCDI-I receptive vocabulary scale can be improved: Differential item functioning between toddlers with autism spectrum disorders and typically-developing infants. Journal of Speech Language and Hearing Research, 50, 1631–1638. CrossRef Bruckner, C., Yoder, P., Stone, W., & Saylor, M. (2007). Construct validity of the MCDI-I receptive vocabulary scale can be improved: Differential item functioning between toddlers with autism spectrum disorders and typically-developing infants. Journal of Speech Language and Hearing Research, 50, 1631–1638. CrossRef
go back to reference Cattani, A., Bonifacio, S., Fertz, M., Iverson, J. M., Zocconi, E., & Caselli, M. C. (2010). Communicative and linguistic development in preterm children: a longitudinal study from 12 to 24 months. International Journal of Language & Communication Disorders, 45, 162–173. doi: 10.​3109/​1368282090281887​0. CrossRef Cattani, A., Bonifacio, S., Fertz, M., Iverson, J. M., Zocconi, E., & Caselli, M. C. (2010). Communicative and linguistic development in preterm children: a longitudinal study from 12 to 24 months. International Journal of Language & Communication Disorders, 45, 162–173. doi: 10.​3109/​1368282090281887​0. CrossRef
go back to reference Chalon, S., et al. (1998). Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. Journal of Nutrition, 128, 2512–2519. PubMed Chalon, S., et al. (1998). Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. Journal of Nutrition, 128, 2512–2519. PubMed
go back to reference Clandinin, M. T., Cheema, S., Field, J., Garg, M. L., Venkatraman, J., & Clandinin, T. R. (1991). Dietary fat: Exogenous determination of membrane structure and cell function. FASEB Journal, 5, 2761–2769. PubMed Clandinin, M. T., Cheema, S., Field, J., Garg, M. L., Venkatraman, J., & Clandinin, T. R. (1991). Dietary fat: Exogenous determination of membrane structure and cell function. FASEB Journal, 5, 2761–2769. PubMed
go back to reference Coderre, E. L., Chernenok, M., Gordon, B., & Ledoux, K. (2017). Linguistic and non-linguistic semantic processing in individuals with autism spectrum disorders: An ERP study. Journal of Autism and Developmental Disorders. doi: 10.​1007/​s10803-016-2985-0. PubMed Coderre, E. L., Chernenok, M., Gordon, B., & Ledoux, K. (2017). Linguistic and non-linguistic semantic processing in individuals with autism spectrum disorders: An ERP study. Journal of Autism and Developmental Disorders. doi: 10.​1007/​s10803-016-2985-0. PubMed
go back to reference Dale, P. S. (1991). The validity of a parent report measure of vocabulary and syntax at 24 months. Journal of Speech and Hearing Research, 34, 565–571. CrossRefPubMed Dale, P. S. (1991). The validity of a parent report measure of vocabulary and syntax at 24 months. Journal of Speech and Hearing Research, 34, 565–571. CrossRefPubMed
go back to reference Delion, S., Chalon, S., Herault, J., Guilloteau, D., Besnard, J.-C., & Durand, G. (1994). Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. Journal of Nutrition, 124, 2466–2476. PubMed Delion, S., Chalon, S., Herault, J., Guilloteau, D., Besnard, J.-C., & Durand, G. (1994). Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. Journal of Nutrition, 124, 2466–2476. PubMed
go back to reference Fang, Y. J., Zhou, M. H., Gao, X. F., Gu, H., & Mei, Y. A. (2011). Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells. The Biochemical Journal, 438, 203–215. doi: 10.​1042/​BJ20110569. CrossRefPubMed Fang, Y. J., Zhou, M. H., Gao, X. F., Gu, H., & Mei, Y. A. (2011). Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells. The Biochemical Journal, 438, 203–215. doi: 10.​1042/​BJ20110569. CrossRefPubMed
go back to reference Fenson, L., Pethick, S. J., Renda, C., Cox, J. L. (2000). Short-form versions of the MacArthur communicative development inventories. Applied Psycholinguistics, 21, 95–116. CrossRef Fenson, L., Pethick, S. J., Renda, C., Cox, J. L. (2000). Short-form versions of the MacArthur communicative development inventories. Applied Psycholinguistics, 21, 95–116. CrossRef
go back to reference Garton, A. F. (1985). The production of this and that by young children. First Language, 6, 29–39. CrossRef Garton, A. F. (1985). The production of this and that by young children. First Language, 6, 29–39. CrossRef
go back to reference Gibson, R. A., Neumann, M. A., Lien, E. L., Boyd, K. A., & Tu, W. C. (2013). Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins Leukotrienes and Essential Fatty Acids, 88, 139–146. doi: 10.​1016/​j.​plefa.​2012.​04.​003. CrossRef Gibson, R. A., Neumann, M. A., Lien, E. L., Boyd, K. A., & Tu, W. C. (2013). Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins Leukotrienes and Essential Fatty Acids, 88, 139–146. doi: 10.​1016/​j.​plefa.​2012.​04.​003. CrossRef
go back to reference Harris, W. S. (2006). The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses. Current Atherosclerosis Reports, 8, 453–459. CrossRefPubMed Harris, W. S. (2006). The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses. Current Atherosclerosis Reports, 8, 453–459. CrossRefPubMed
go back to reference Ikemoto, A., Kobayashi, T., Watanabe, S., & Okuyama, H. (1997). Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. Neurochemical Research, 22, 671–678. CrossRefPubMed Ikemoto, A., Kobayashi, T., Watanabe, S., & Okuyama, H. (1997). Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. Neurochemical Research, 22, 671–678. CrossRefPubMed
go back to reference Johnson, M., Fransson, G., Ostlund, S., Areskoug, B., & Gillberg, C. (2016). Omega 3/6 fatty acids for reading in children: A randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden. Journal of Child Psychology and Psychiatry and Allied Disciplines. doi: 10.​1111/​jcpp.​12614. Johnson, M., Fransson, G., Ostlund, S., Areskoug, B., & Gillberg, C. (2016). Omega 3/6 fatty acids for reading in children: A randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden. Journal of Child Psychology and Psychiatry and Allied Disciplines. doi: 10.​1111/​jcpp.​12614.
go back to reference Johnson, S., Hollis, C., Kochhar, P., Hennessey, E., Wolke, D., & Marlow, N. (2010). Autism spectrum disorders in extremely preterm children. Journal of Pediatrics, 156, 525–531. CrossRefPubMed Johnson, S., Hollis, C., Kochhar, P., Hennessey, E., Wolke, D., & Marlow, N. (2010). Autism spectrum disorders in extremely preterm children. Journal of Pediatrics, 156, 525–531. CrossRefPubMed
go back to reference Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L. (2005). Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity. Biological Psychiatry, 57, 229–238. doi: 10.​1016/​j.​biopsych.​2004.​11.​009. CrossRefPubMed Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L. (2005). Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity. Biological Psychiatry, 57, 229–238. doi: 10.​1016/​j.​biopsych.​2004.​11.​009. CrossRefPubMed
go back to reference Jumpsen, J., Lien, E. L., Goh, Y. K., & Clandinin, M. T. (1997a). During neuronal and glial cell development diet n-6 to n-3 fatty acid ratio alters the fatty acid composition of phosphatidylinositol and phosphatidylserine. Biochimica et Biophysica Acta, 1347, 40–50. CrossRefPubMed Jumpsen, J., Lien, E. L., Goh, Y. K., & Clandinin, M. T. (1997a). During neuronal and glial cell development diet n-6 to n-3 fatty acid ratio alters the fatty acid composition of phosphatidylinositol and phosphatidylserine. Biochimica et Biophysica Acta, 1347, 40–50. CrossRefPubMed
go back to reference Jumpsen, J., Lien, E. L., Goh, Y. K., & Clandinin, M. T. (1997b). Small changes of dietary (n-6) and (n-3)/fatty acid content ratio alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. Journal of Nutrition, 127, 724–731. PubMed Jumpsen, J., Lien, E. L., Goh, Y. K., & Clandinin, M. T. (1997b). Small changes of dietary (n-6) and (n-3)/fatty acid content ratio alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. Journal of Nutrition, 127, 724–731. PubMed
go back to reference Kato, K., Uruno, K., Saito, K., & Kato, H. (1991). Both arachidonic acid and 1-oleoyl-2-acetyl glycerol in low magnesium solution induce long-term potentiation in hippocampal CA1 neurons in vitro. Brain Research, 563, 94–100. CrossRefPubMed Kato, K., Uruno, K., Saito, K., & Kato, H. (1991). Both arachidonic acid and 1-oleoyl-2-acetyl glycerol in low magnesium solution induce long-term potentiation in hippocampal CA1 neurons in vitro. Brain Research, 563, 94–100. CrossRefPubMed
go back to reference Keim, S. A., et al. (under review). Omega-3 and -6 fatty acid supplementation may benefit autism symptoms based on parent report in preterm toddlers. The Journal of Nutrition. Keim, S. A., et al. (under review). Omega-3 and -6 fatty acid supplementation may benefit autism symptoms based on parent report in preterm toddlers. The Journal of Nutrition.
go back to reference Koletzko, B., et al. (2008). The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: Review of current knowledge and consensus recommendations. Journal of Perinatal Medicine, 36, 5–14. doi: 10.​1515/​JPM.​2008.​001. PubMed Koletzko, B., et al. (2008). The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: Review of current knowledge and consensus recommendations. Journal of Perinatal Medicine, 36, 5–14. doi: 10.​1515/​JPM.​2008.​001. PubMed
go back to reference Lapillonne, A., & Moltu, S. J. (2016). Long-chain polyunsaturated fatty acids and clinical outcomes of preterm infants. Annals of Nutrition and Metabolism, 69(Suppl 1), 35–44. doi: 10.​1159/​000448265. PubMed Lapillonne, A., & Moltu, S. J. (2016). Long-chain polyunsaturated fatty acids and clinical outcomes of preterm infants. Annals of Nutrition and Metabolism, 69(Suppl 1), 35–44. doi: 10.​1159/​000448265. PubMed
go back to reference Lauritzen, L., Jorgensen, M. H., Olsen, S. F., Straarup, E. M., & Michaelsen, K. F. (2005). Maternal fish oil supplementation in lactation: Effect on developmental outcome in breast-fed infants. Reproduction Nutrition Development, 45, 535–547. doi: 10.​1051/​rnd:​2005044. CrossRef Lauritzen, L., Jorgensen, M. H., Olsen, S. F., Straarup, E. M., & Michaelsen, K. F. (2005). Maternal fish oil supplementation in lactation: Effect on developmental outcome in breast-fed infants. Reproduction Nutrition Development, 45, 535–547. doi: 10.​1051/​rnd:​2005044. CrossRef
go back to reference Lynch, M. A., & Voss, K. L. (1994). Membrane arachidonic acid concentration correlates with age and induction of long-term potentiation in the dentate gyrus in the rat. European Journal of Neuroscience, 6, 1008–1014. CrossRefPubMed Lynch, M. A., & Voss, K. L. (1994). Membrane arachidonic acid concentration correlates with age and induction of long-term potentiation in the dentate gyrus in the rat. European Journal of Neuroscience, 6, 1008–1014. CrossRefPubMed
go back to reference Martinez, M. (1992). Tissue levels of polyunsaturated fatty acids during early human development. Journal of Pediatrics, 120, S129–S138. CrossRefPubMed Martinez, M. (1992). Tissue levels of polyunsaturated fatty acids during early human development. Journal of Pediatrics, 120, S129–S138. CrossRefPubMed
go back to reference Martinez, M., & Mougan, I. (1998). Fatty acid composition of human brain phospholipids during normal development. Journal of Neurochemistry, 71, 2528–2533. CrossRefPubMed Martinez, M., & Mougan, I. (1998). Fatty acid composition of human brain phospholipids during normal development. Journal of Neurochemistry, 71, 2528–2533. CrossRefPubMed
go back to reference Meldrum, S. J., D’Vaz, N., Simmer, K., Dunstan, J. A., Hird, K., & Prescott, S. L. (2012). Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: A randomised controlled trial. The British Journal of Nutrition, 108, 1443–1454. doi: 10.​1017/​S000711451100687​8. CrossRefPubMed Meldrum, S. J., D’Vaz, N., Simmer, K., Dunstan, J. A., Hird, K., & Prescott, S. L. (2012). Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: A randomised controlled trial. The British Journal of Nutrition, 108, 1443–1454. doi: 10.​1017/​S000711451100687​8. CrossRefPubMed
go back to reference Moriguchi, T., Greiner, R. S., & Salem, N. (2000). Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. Journal of Neurochemistry, 75, 2563–2573. CrossRefPubMed Moriguchi, T., Greiner, R. S., & Salem, N. (2000). Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. Journal of Neurochemistry, 75, 2563–2573. CrossRefPubMed
go back to reference Mundy, P., Sigman, M., Ungerer, J., & Sherman, T. (1987). Nonverbal communnication and play correlates of language development in autistic children. Journal of Autism and Developmental Disorders, 17, 349–364. CrossRefPubMed Mundy, P., Sigman, M., Ungerer, J., & Sherman, T. (1987). Nonverbal communnication and play correlates of language development in autistic children. Journal of Autism and Developmental Disorders, 17, 349–364. CrossRefPubMed
go back to reference Parletta, N., Niyonsenga, T., Duff, J. (2016). Omega-3 and omega-6 polyunsaturated fatty acid levels and correlations with symptoms in children with attention deficit hyperactivity disorder, autistic spectrum disorder and typically developing controls. PLoS ONE. doi: 10.​4226/​78/​572fdf0edfb74. PubMedPubMedCentral Parletta, N., Niyonsenga, T., Duff, J. (2016). Omega-3 and omega-6 polyunsaturated fatty acid levels and correlations with symptoms in children with attention deficit hyperactivity disorder, autistic spectrum disorder and typically developing controls. PLoS ONE. doi: 10.​4226/​78/​572fdf0edfb74. PubMedPubMedCentral
go back to reference Patrick, R. P., & Ames, B. N. (2015). Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. The FASEB Journal, 29, 2207–2222. doi: 10.​1096/​fj.​14-268342. CrossRefPubMed Patrick, R. P., & Ames, B. N. (2015). Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. The FASEB Journal, 29, 2207–2222. doi: 10.​1096/​fj.​14-268342. CrossRefPubMed
go back to reference Rescorla, L. (1991). Identifying expressive language delay at two. Topics in Language Disorders, 11, 14–20. CrossRef Rescorla, L. (1991). Identifying expressive language delay at two. Topics in Language Disorders, 11, 14–20. CrossRef
go back to reference Richardson, A. J., & Montgomery, P. (2005). The Oxford-Durham study: A randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics, 115, 1360–1366. doi: 10.​1542/​peds.​2004-2164. CrossRefPubMed Richardson, A. J., & Montgomery, P. (2005). The Oxford-Durham study: A randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics, 115, 1360–1366. doi: 10.​1542/​peds.​2004-2164. CrossRefPubMed
go back to reference Ring, E.D., Fenson, L. (2000). The correspondence between parent report and child performance for receptive and expressive vocabulary beyond infancy. First Language, 20, 141–159. CrossRef Ring, E.D., Fenson, L. (2000). The correspondence between parent report and child performance for receptive and expressive vocabulary beyond infancy. First Language, 20, 141–159. CrossRef
go back to reference Schaechter, J. D., & Benowitz, L. I. (1993). Activation of protein kinase C by arachidonic acid selectively enhances the phosphorylation of GAP-43 in nerve terminal membranes. The Journal of Neuroscience, 13, 4361–4371. PubMed Schaechter, J. D., & Benowitz, L. I. (1993). Activation of protein kinase C by arachidonic acid selectively enhances the phosphorylation of GAP-43 in nerve terminal membranes. The Journal of Neuroscience, 13, 4361–4371. PubMed
go back to reference Simmer, K., Schulzke, S., Patole, S. K. (2008). Longchain polyunsaturated fatty acid supplementation in preterm infants (Review). The Cochrane Library, 1, 1–57. Simmer, K., Schulzke, S., Patole, S. K. (2008). Longchain polyunsaturated fatty acid supplementation in preterm infants (Review). The Cochrane Library, 1, 1–57.
go back to reference Spittle, A. J., et al. (2017). Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm. Developmental Medicine and Child Neurology, 59, 207–215. doi: 10.​1111/​dmcn.​13297. CrossRefPubMed Spittle, A. J., et al. (2017). Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm. Developmental Medicine and Child Neurology, 59, 207–215. doi: 10.​1111/​dmcn.​13297. CrossRefPubMed
go back to reference Verhaeghe, L., Dereu, M., Warreyn, P., De Groote, I., Vanhaesebrouck, P., & Roeyers, H. (2016). Extremely preterm born children at very high risk for developing autism spectrum disorder. Child Psychiatry and Human Development, 47, 729–739. doi: 10.​1007/​s10578-015-0606-3. CrossRefPubMed Verhaeghe, L., Dereu, M., Warreyn, P., De Groote, I., Vanhaesebrouck, P., & Roeyers, H. (2016). Extremely preterm born children at very high risk for developing autism spectrum disorder. Child Psychiatry and Human Development, 47, 729–739. doi: 10.​1007/​s10578-015-0606-3. CrossRefPubMed
go back to reference Wainwright, P. E., Jalali, E., Mutsaers, M., Bell, R., & Cvitkovic, S. (1999). An imbalance of dietary essential fatty acids retards behavioral development in mice. Physiology and Behavior, 66, 833–839. CrossRefPubMed Wainwright, P. E., Jalali, E., Mutsaers, M., Bell, R., & Cvitkovic, S. (1999). An imbalance of dietary essential fatty acids retards behavioral development in mice. Physiology and Behavior, 66, 833–839. CrossRefPubMed
go back to reference Wainwright, P. E., Xing, H.-C., Mutsaers, L., McCutcheon, D., & Kyle, D. (1997). Arachidonic acid offsests the effects of mouse brain and behavior of a diet with low (n−6):(n−3) ratio and very high levels of docosahexaenoic acid. Journal of Nutrition, 127, 184–193. PubMed Wainwright, P. E., Xing, H.-C., Mutsaers, L., McCutcheon, D., & Kyle, D. (1997). Arachidonic acid offsests the effects of mouse brain and behavior of a diet with low (n−6):(n−3) ratio and very high levels of docosahexaenoic acid. Journal of Nutrition, 127, 184–193. PubMed
go back to reference Willatts, P., Forsyth, J. S. (2000). The role of long-chain polyunsaturated fatty acids in infant cognitive development. Prostaglandins Leukotrienes and Essential Fatty Acids, 63, 95–100. CrossRef Willatts, P., Forsyth, J. S. (2000). The role of long-chain polyunsaturated fatty acids in infant cognitive development. Prostaglandins Leukotrienes and Essential Fatty Acids, 63, 95–100. CrossRef
go back to reference Willett, W., et al. (1985). Reproducibility and validity of a semiquantitative food frequency questionnaire. American Journal of Epidemiology, 122, 51–65. CrossRefPubMed Willett, W., et al. (1985). Reproducibility and validity of a semiquantitative food frequency questionnaire. American Journal of Epidemiology, 122, 51–65. CrossRefPubMed
go back to reference Zimmer, L., Delpal, S., Guilloteau, D., Aioun, J., Durand, G., & Chalon, S. (2000). Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex. Neuroscience Letters, 284, 25–28. CrossRefPubMed Zimmer, L., Delpal, S., Guilloteau, D., Aioun, J., Durand, G., & Chalon, S. (2000). Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex. Neuroscience Letters, 284, 25–28. CrossRefPubMed
Metagegevens
Titel
Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms
Auteurs
Kelly W. Sheppard
Kelly M. Boone
Barbara Gracious
Mark A. Klebanoff
Lynette K. Rogers
Joseph Rausch
Christopher Bartlett
Daniel L. Coury
Sarah A. Keim
Publicatiedatum
26-07-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 11/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3249-3