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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-08-2011 | Original paper

Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity

Auteurs: Chris Oliver, Katy Berg, Jo Moss, Kate Arron, Cheryl Burbidge

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2011

Abstract

We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4–51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes.

vorige artikel The Role of Adaptive Behavior in Autism Spectrum Disorders: Implications for Functional Outcome

volgende artikel The Efficacy of a Social Skills Group Intervention for Improving Social Behaviors in Children with High Functioning Autism Spectrum Disorders

The n may vary for the analysis due to missing data.

FXS and LS groups excluded from analysis due to the X linked nature of the syndromes and exclusion of females in the FXS group.

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Titel: Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity
Auteurs: Chris Oliver
Katy Berg
Jo Moss
Kate Arron
Cheryl Burbidge
Publicatiedatum: 01-08-2011
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-1125-5

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