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Journal of Autism and Developmental Disorders
Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2022

17-02-2021 | Brief Report

Brief Report: Role of Parent-Reported Executive Functioning and Anxiety in Insistence on Sameness in Individuals with Germline PTEN Mutations

Auteurs: Mirko Uljarević, Thomas W. Frazier, Gaëlle Rached, Robyn M. Busch, Patricia Klaas, Siddharth Srivastava, Julian A. Martinez-Agosto, Mustafa Sahin, Charis Eng, Antonio Y. Hardan, on behalf of the Developmental Synaptopathies Consortium

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2022

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Abstract

This study aimed to characterize the relationship between insistence on sameness (IS), executive functioning (EF) and anxiety among individuals with PTEN mutations and individuals with macrocephalic ASD. The sample included 38 individuals with PTEN mutation and ASD diagnosis (PTEN-ASD; Mage = 8.93 years, SDage = 4.75), 23 with PTEN mutation without ASD (PTEN-no ASD; Mage = 8.94 years; SDage = 4.85) and 25 with ASD and macrocephaly but with no PTEN mutation (Macro-ASD; Mage = 11.99 years; SDage = 5.15). The final model accounted for 45.7% of variance in IS, with Set-Shifting EF subdomain as a unique independent predictor (t = 4.12, p < 0.001). This investigation provides the first preliminary evidence for the EF—anxiety—IS interrelationship in individuals with PTEN mutations and with macrocephalic ASD.
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Metagegevens
Titel
Brief Report: Role of Parent-Reported Executive Functioning and Anxiety in Insistence on Sameness in Individuals with Germline PTEN Mutations
Auteurs
Mirko Uljarević
Thomas W. Frazier
Gaëlle Rached
Robyn M. Busch
Patricia Klaas
Siddharth Srivastava
Julian A. Martinez-Agosto
Mustafa Sahin
Charis Eng
Antonio Y. Hardan
on behalf of the Developmental Synaptopathies Consortium
Publicatiedatum
17-02-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04881-5

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