Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2022

26-02-2021 | Original Paper

Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism

Auteurs: Simge Aykan, Meghan H. Puglia, Canan Kalaycıoğlu, Kevin A. Pelphrey, Timur Tuncalı, Erhan Nalçacı

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in NKCC1 (rs3087889) and KCC2 (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p < 0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p < 0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Association. CrossRef American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Association. CrossRef
go back to reference Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. CrossRef Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. CrossRef
go back to reference Ben-Ari, Y., Cherubini, E., Corradetti, R., & Gaiarsa, J. L. (1989). Giant synaptic potentials in immature rat CA3 hippocampal neurones. The Journal of physiology, 416(1), 303–325. CrossRef Ben-Ari, Y., Cherubini, E., Corradetti, R., & Gaiarsa, J. L. (1989). Giant synaptic potentials in immature rat CA3 hippocampal neurones. The Journal of physiology, 416(1), 303–325. CrossRef
go back to reference Donaldson, P. H., Kirkovski, M., Rinehart, N. J., & Enticott, P. G. (2018). Autism-relevant traits interact with temporoparietal junction stimulation effects on social cognition: A high-definition transcranial direct current stimulation and electroencephalography study. European Journal of Neuroscience, 47(6), 669–681. https://​doi.​org/​10.​1111/​ejn.​13675. CrossRef Donaldson, P. H., Kirkovski, M., Rinehart, N. J., & Enticott, P. G. (2018). Autism-relevant traits interact with temporoparietal junction stimulation effects on social cognition: A high-definition transcranial direct current stimulation and electroencephalography study. European Journal of Neuroscience, 47(6), 669–681. https://​doi.​org/​10.​1111/​ejn.​13675. CrossRef
go back to reference Gołȩbiewski, H., Eckersdorf, B., & Konopacki, J. (1996). Cholinergic/GABAergic interaction in the production of EEG theta oscillations in rat hippocampal formation in vitro. Acta Neurobiologiae Experimentalis, 56, 147–153. PubMed Gołȩbiewski, H., Eckersdorf, B., & Konopacki, J. (1996). Cholinergic/GABAergic interaction in the production of EEG theta oscillations in rat hippocampal formation in vitro. Acta Neurobiologiae Experimentalis, 56, 147–153. PubMed
go back to reference IBM Corp. Released 2011. (2011). IBM SPSS Statistics for Windows, Version 22.0, 2011. IBM Corp. Released 2011. (2011). IBM SPSS Statistics for Windows, Version 22.0, 2011.
go back to reference Kopnik, V. S., Neiderhiser, J. M., Defries, J. C., & Plomin, R. (2017). Behavioral Genetics. In V. S. Kopnik, J. M. Neiderhiser, J. C. Defries, & R. Plomin (Eds.) 7th ed. New York: Macmillian Higher Education. Kopnik, V. S., Neiderhiser, J. M., Defries, J. C., & Plomin, R. (2017). Behavioral Genetics. In V. S. Kopnik, J. M. Neiderhiser, J. C. Defries, & R. Plomin (Eds.) 7th ed. New York: Macmillian Higher Education.
go back to reference Köse, S., Bora, E., Erermıs, S., & Aydın, C. (2010). Psychometric features of Turkish version of Autism-Spectrum Quotient. Anatolian Journal of Psychiatry, 11, 253–260. Köse, S., Bora, E., Erermıs, S., & Aydın, C. (2010). Psychometric features of Turkish version of Autism-Spectrum Quotient. Anatolian Journal of Psychiatry, 11, 253–260.
go back to reference Nalçaci, E., Kalaycioğlu, C., Güneş, E., & Ciçek, M. (2002). Reliability and validity of a handedness questionnaire. Turkish Journal of Psychiatry, 13(2), 99–106. PubMed Nalçaci, E., Kalaycioğlu, C., Güneş, E., & Ciçek, M. (2002). Reliability and validity of a handedness questionnaire. Turkish Journal of Psychiatry, 13(2), 99–106. PubMed
Metagegevens
Titel
Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism
Auteurs
Simge Aykan
Meghan H. Puglia
Canan Kalaycıoğlu
Kevin A. Pelphrey
Timur Tuncalı
Erhan Nalçacı
Publicatiedatum
26-02-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04924-x