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Journal of Autism and Developmental Disorders
Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2015

01-06-2015 | Brief Report

Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder

Auteurs: Esther Vierck, Jeremy M. Silverman

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2015

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Abstract

Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD.
vorige artikel Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Literatuur
Auroux, M. R., Mayaux, M. J., Guihardmoscato, M. L., Fromantin, M., Barthe, J., & Schwartz, D. (1989). Paternal age and mental functions of progeny in man. Human Reproduction, 4(7), 794–797.PubMed
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25(1), 63–77.CrossRefPubMed
Banach, R., Thompson, A., Szatmari, P., Goldberg, J., Tuff, L., Zwaigenbaum, L., et al. (2009). Brief Report: Relationship between non-verbal IQ and gender in autism. Journal of Autism and Developmental Disorders,. doi:10.​1007/​s10803-008-0612-4.PubMed
Ben-Itzchak, E., Ben-Shachar, S., & Zachor, D. A. (2013). Specific neurological phenotypes in autism spectrum disorders are associated with sex representation. Autism Research, 6(6), 596–604.CrossRefPubMed
Ben-Itzchak, E., Lahat, E., & Zachor, D. A. (2011). Advanced parental ages and low birth weight in autism spectrum disorders-rates and effect on functioning. Research in Developmental Disabilities,. doi:10.​1016/​j.​ridd.​2011.​03.​004.
Cantor, R. M., Kono, N., Duvall, J. A., Alvarez-Retuerto, A., Stone, J. L., Alarcon, M., et al. (2005). Replication of autism linkage: Fine-mapping peak at 17q21. American Journal of Human Genetics, 76(6), 1050–1056.CrossRefPubMedCentralPubMed
Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 86–97.CrossRefPubMed
Croen, L. A., Najjar, D. V., Fireman, B., & Grether, J. K. (2007). Maternal and paternal age and risk of autism spectrum disorders. Archives of Pediatrics and Adolescent Medicine, 161(4), 334–340.CrossRefPubMed
Crow, J. F. (1997). The high spontaneous mutation rate: Is it a health risk? Proceedings of the National Academy of Sciences of the United States of America, 94(16), 8380–8386.CrossRefPubMedCentralPubMed
Elliot, C. (1990). Differential abilities scale. San Antonio: Psychological Corporation.
Folstein, S., & Rutter, M. (1977). Genetic influences and infantile autism. Nature, 265(5596), 726–728.CrossRefPubMed
Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33(4), 365–382.CrossRefPubMed
Glasson, E. J., Bower, C., Petterson, B., de Klerk, N., Chaney, G., & Hallmayer, J. F. (2004). Perinatal factors and the development of autism: A population study. Archives of General Psychiatry, 61(6), 618–627.CrossRefPubMed
Griffiths, R. (1996). Griffiths mental development scales (birth to 2 years) (revision). Oxon: The Test Agency Limited.
Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095–1102.CrossRefPubMed
Hartley, S. L., & Sikora, D. M. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. Journal of Autism and Developmental Disorders, 39(12), 1715–1722.CrossRefPubMedCentralPubMed
Holtmann, M., Bölte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49(5), 361–366.CrossRefPubMed
Hultman, C. M., Sandin, S., Levine, S. Z., Lichtenstein, P., & Reichenberg, A. (2011). Advancing paternal age and risk of autism: New evidence from a population-based study and a meta-analysis of epidemiological studies. Molecular Psychiatry, 16(12), 1203–1212.CrossRefPubMed
Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., et al. (2014). A higher mutational burden in females supports a “female protective model” in neurodevelopmental disorders. American Journal of Human Genetics, 94(3), 415–425.CrossRefPubMedCentralPubMed
Jones, M. B., & Szatmari, P. (1988). Stoppage rules and genetic studies of autism. Journal of Autism and Developmental Disorders, 18(1), 31–40.CrossRefPubMed
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46(9), 963–971.CrossRefPubMed
Lopez-Castroman, J., Gómez, D. D., Belloso, J. J. C., Fernandez-Navarro, P., Perez-Rodriguez, M. M., Villamor, I. B., et al. (2010). Differences in maternal and paternal age between schizophrenia and other psychiatric disorders. Schizophrenia Research, 116(2), 184–190.CrossRefPubMed
Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMed
Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMed
Lord, C., & Schopler, E. (1985). Brief report: Differences in sex ratios in autism as a function of measured intelligence. Journal of Autism and Developmental Disorders, 15(2), 185–193.CrossRefPubMed
Lord, C., Schopler, E., & Revicki, D. (1982). Sex differences in autism. Journal of Autism and Developmental Disorders, 12(4), 317–330.CrossRefPubMed
Lundstrom, S., Haworth, C. M. A., Carlstrom, E., Gillberg, C., Mill, J., Rastam, M., et al. (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: Findings from two nationally representative twin studies. Journal of Child Psychology and Psychiatry, 51(7), 850–856.CrossRefPubMed
Luo, R., Sanders, S. J., Tian, Y., Voineagu, I., Huang, N., Chu, S. H., et al. (2012). Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders. The American Journal of Human Genetics, 91(1), 38–55.CrossRef
Lupski, J. R. (2007). Genomic rearrangements and sporadic disease. Nature Genetics, 39(7 Suppl), S43–S47.CrossRefPubMed
Ma, D. Q., Cuccaro, M. L., Jaworski, J. M., Haynes, C. S., Stephan, D. A., Parod, J., et al. (2007). Dissecting the locus heterogeneity of autism: Significant linkage to chromosome 12q14. Molecular Psychiatry, 12(4), 376–384.CrossRefPubMed
Maimburg, R. D., & Vaeth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257–264.CrossRefPubMed
Malaspina, D., Reichenberg, A., Weiser, M., Fennig, S., Davidson, M., Harlap, S., et al. (2005). Paternal age and intelligence: Implications for age-related genomic changes in male germ cells. Psychiatric Genetics, 15(2), 117–125.CrossRefPubMed
Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2012). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313.CrossRefPubMed
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., et al. (2008). Structural variation of chromosomes in autism spectrum disorder. American Journal of Human Genetics, 82(2), 477–488.CrossRefPubMedCentralPubMed
Miles, J. H., Takahashi, T. N., Bagby, S., Sahota, P. K., Vaslow, D. F., Wang, C. H., et al. (2005). Essential versus complex autism: Definition of fundamental prognostic subtypes. American Journal of Medical Genetics Part A, 135(2), 171–180.CrossRefPubMed
Miller, M. C. (2006). Older father, autistic child. Harvard Mental Health Letter, 23, 8.
Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., et al. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466(7304), 368–372.CrossRefPubMedCentralPubMed
Puleo, C. M., Reichenberg, A., Smith, C. J., Kryzak, L. A., & Silverman, J. M. (2008). Do autism-related personality traits explain higher paternal age in autism? Molecular Psychiatry, 13(3), 243–244.CrossRefPubMed
Raven, J. C., Court, J. H., & Raven, J. (1998a). Raven manual. Section 3: Standard progressive matrices. London: Oxford Psychologists Press.
Raven, J., Raven, J. C., & Court, J. H. (1998b). Manual for Raven’s progressive matrices and vocabulary scales. Section 2: The coloured progressive matrices.. Oxford: Oxford Psychologists Press.
Reichenberg, A., Gross, R., Weiser, M., Bresnahan, M., Silverman, J., Harlap, S., et al. (2006). Advancing paternal age and autism. Archives of General Psychiatry, 63(9), 1026–1032.CrossRefPubMed
Robinson, E. B., Munir, K., McCormick, M. C., Koenen, K. C., & Santangelo, S. L. (2011). Brief Report: No association between parental age and extreme social-communicative autistic traits in the general population. Journal of Autism and Developmental Disorders, 41(12), 1733–1737.CrossRefPubMedCentralPubMed
Roid, G. H., & Miller, L. J. (1997). Leiter international performance scale-revised. Wood Dale, IL: Stoelting Co.
Saha, S., Barnett, A. G., Foldi, C., Burne, T. H., Eyles, D. W., Buka, S. L., et al. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood. PLoS Medicine, 6(3), e1000040.CrossRefPubMedCentral
Sanders, S. J., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., et al. (2012). De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature, 485(7397), 237–241.CrossRefPubMedCentralPubMed
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., et al. (2007). Strong association of de novo copy number mutations with autism. Science, 316(5823), 445–449.CrossRefPubMedCentralPubMed
Silverman, J. M., Smith, C. J., Schmeidler, J., Hollander, E., Lawlor, B. A., Fitzgerald, M., et al. (2002). Symptom domains in autism and related conditions: Evidence for familiality. American Journal of Medical Genetics, 114(1), 64–73.CrossRefPubMed
Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (2005). Vineland adaptive behavior scales, second edition (vineland-II). Circle Pines, MN: American Guidance Service.
Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I. C., Jakobsson, G., et al. (1989). A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. Journal of Child Psychology and Psychiatry, 30(3), 405–416.CrossRefPubMed
Stone, J. L., Merriman, B., Cantor, R. M., Yonan, A. L., Gilliam, T. C., Geschwind, D. H., et al. (2004). Evidence for sex-specific risk alleles in autism spectrum disorder. American Journal of Human Genetics, 75(6), 1117–1123.CrossRefPubMedCentralPubMed
Szatmari, P., Jones, M. B., Zwaigenbaum, L., & MacLean, J. E. (1998). Genetics of autism: Overview and new directions. Journal of Autism and Developmental Disorders, 28(5), 351–368.CrossRefPubMed
Szatmari, P., Liu, X.-Q., Goldberg, J., Zwaigenbaum, L., Paterson, A. D., Woodbury-Smith, M., et al. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159(1), 5–12.CrossRef
Szatmari, P., Paterson, A. D., Zwaigenbaum, L., Roberts, W., Brian, J., Liu, X. Q., et al. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39(3), 319–328.CrossRefPubMed
Vestergaard, M., Mork, A., Madsen, K. M., & Olsen, J. (2005). Paternal age and epilepsy in the offspring. European Journal of Epidemiology, 20(12), 1003–1005.CrossRefPubMed
Volkmar, F. R., Szatmari, P., & Sparrow, S. S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23(4), 579–591.CrossRefPubMed
Wechsler, D. (1974). Manual for the wechsler intelligence scale for children-revised. San Antonio, TX: Psychological Corporation.
Wechsler, D. (1981). Manual for the wechsler adult intelligence scale—revised. New York, NY: Psychological Corporation.
Wechsler, D. (1989). WPPSI-R, manual: Wechsler preschool and primary scale of intelligence—revised. New York, NY: Psychological Corporation.
Wechsler, D. (1991). WISC-III: Wechsler intelligence scale for children. San Antonio, TX: Psychological Corporation.
Wechsler, D. (1997). Wechsler adult intelligence scale (3rd ed.). San Antonio, TX: Harcourt Assessment.
Wechsler, D. (1999). Wechsler Abbreviated Scale of Intelligence. New York, NY: Harcourt Brace & Company, The Psychological Corporation.
Wechsler, D. (2003). WISC-IV Wechsler Intelligence Scale for Children: Technical and Interpretative: Manual. London: Pearson.
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., et al. (2008). Association between microdeletion and microduplication at 16p11.2 and autism. New England Journal of Medicine, 358(7), 667–675.CrossRefPubMed
Zachor, D. A., Ben-Shachar, S., & Ben-Itzchak, E. (2013). Do risk factors for autism spectrum disorders affect gender representation? Research in Autism Spectrum Disorders, 7(11), 1397–1402.CrossRef
Zhao, X., Leotta, A., Kustanovich, V., Lajonchere, C., Geschwind, D. H., Law, K., et al. (2007). A unified genetic theory for sporadic and inherited autism. Proceedings of the National Academy of Sciences of the United States of America, 104(31), 12831–12836.CrossRefPubMedCentralPubMed
Zwaigenbaum, L., Bryson, S. E., Szatmari, P., Brian, J., Smith, I. M., Roberts, W., et al. (2012). Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. Journal of Autism and Developmental Disorders, 42(12), 2585–2596.CrossRefPubMed
Metagegevens
Titel
Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder
Auteurs
Esther Vierck
Jeremy M. Silverman
Publicatiedatum
01-06-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2346-9

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