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Journal of Autism and Developmental Disorders

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01-12-2012 | Original Paper

Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort

Auteurs: Lonnie Zwaigenbaum, Susan E. Bryson, Peter Szatmari, Jessica Brian, Isabel M. Smith, Wendy Roberts, Tracy Vaillancourt, Caroline Roncadin

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2012

Abstract

Sex differences were examined in 3-year-olds with autism spectrum disorders (ASD) ascertained from a high-risk cohort, and high- and low-risk comparison groups. Participants included 319 high-risk siblings and 129 low-risk controls. Eighty-five siblings were diagnosed with ASD, including 57 of 176 boys (32.4 %) and 28 of 143 girls (19.6 %), implying a relative odds of ASD of 1.65 in boys versus girls. There were modest sex differences on cognitive and adaptive skills and ASD symptom severity at age 3, but differences between boys and girls with ASD mirrored those in the non-ASD groups. The lower than expected male-to-female ratio, and the relatively high cognitive level among diagnosed children, suggest that we have identified an unanticipated number of higher-functioning girls with ASD.

vorige artikel Microglia in the Cerebral Cortex in Autism

volgende artikel Network Characteristics, Perceived Social Support, and Psychological Adjustment in Mothers of Children with Autism Spectrum Disorder

Of 85 HR siblings clinically diagnosed with ASD, 78 met criteria on the ADOS, 52 met criteria on the ADI-R and 48 met criteria on both. Only 3 children diagnosed with ASD were sub-threshold on both the ADOS and ADI-R at 3 years, 2 of whom met ADOS criteria for ASD and received initial clinical diagnoses at 24 months.

Anello, A., Reichenberg, A., Luo, X., Schmeidler, J., Hollander, E., Smith, C. J., et al. (2009). Brief report: Parental age and the sex ratio in autism. Journal of Autism and Developmental Disorders, 39, 1487–1492.PubMedCrossRef

Autism and Developmental Disabilities Monitoring Network. (2007). Prevalence of autism spectrum disorders–autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR Surveillance Summaries, 56, 12–28.

Auyeung, B., Taylor, K., Hackett, G., & Baron-Cohen, S. (2010). Foetal testosterone and autistic traits in 18 to 24-month-old children. Molecular Autism, 1, 11.PubMedCrossRef

Baird, G., Douglas, H. R., & Murphy, M. S. (2011). Recognizing and diagnosing autism in children and young people: Summary of NICE guidance. British Medical Journal, 343, d6360.PubMedCrossRef

Banach, R., Thompson, A., Szatmari, P., Goldberg, J., Tuff, L., Zwaigenbaum, L., et al. (2009). Brief report: Relationship between non-verbal IQ and gender in autism. Journal of Autism and Developmental Disorders, 39, 188–193.PubMedCrossRef

Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005). Sex differences in the brain: Implications for explaining autism. Science, 310, 819–823.PubMedCrossRef

Blasi, F., Bacchelli, E., Pesaresi, G., Carone, S., Bailey, A. J., & Maestrini, E. (2006). Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. American Journal of Medical Genetics (Neuropsychiatric Genetics), 141B, 220–221.CrossRef

Bryson, S. E., Clark, B. S., & Smith, I. M. (1988). First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry, 29, 433–445.PubMedCrossRef

Bryson, S. E., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24.PubMedCrossRef

Carter, A. S., Volkmar, F. R., Sparrow, S. S., Wang, J. J., Lord, C., Dawson, G., et al. (1998). The Vineland Adaptive Behavior Scales: Supplementary norms for individuals with autism. Journal of Autism and Developmental Disorders, 28, 287–302.PubMedCrossRef

Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmetnal Disorders, 37, 86–97.CrossRef

Celestino-Soper, P. B., Shaw, C. A., Sanders, S. J., Li, J., Murtha, M. T., Ercan-Sencicek, A. G., et al. (2011). Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE. Human Molecular Genetics, 20, 4360–4370.PubMedCrossRef

Charman, T., Taylor, E., Drew, A., Cockerill, H., Brown, J. A., & Baird, G. (2005). Outcome at 7 years of children diagnosed with autism at age 2: Predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. Journal of Child Psychology and Psychiatry, 46, 500–513.PubMedCrossRef

Christian, S. L., Brune, C. W., Sudi, J., Kumar, R. A., Liu, S., Karamohamed, S., et al. (2008). Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder. Biological Psychiatry, 63, 1111–1117.PubMedCrossRef

Coolican, J., Bryson, S. E., & Zwaigenbaum, L. (2008). Brief report: Data on the Stanford-Binet Intelligence Scales (5th ed.) in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 38, 190–197.PubMedCrossRef

Ehlers, S., & Gillberg, C. (1993). The epidemiology of Asperger syndrome. A total population study. Journal of Child Psychology and Psychiatry, 34, 1327–1350.PubMedCrossRef

Filges, I., Röthlisberger, B., Blattner, A., Boesch, N., Demougin, P., Wenzel, F., et al. (2011). Deletion in Xp22.11: PTCHD1 is a candidate gene for X-linked intellectual disability with or without autism. Clinical Genetics, 79, 79–85.PubMedCrossRef

Fombonne, E. (2008). Is autism getting commoner? British Journal of Psychiatry, 193, 59.PubMedCrossRef

Giarelli, E., Wiggins, L. D., Rice, C. E., Levy, S. E., Kirby, R. S., Pinto-Martin, J., et al. (2010). Sex differences in the evaluation and diagnosis of autism spectrum disorders among children. Disability Health Journal, 3, 107–116.CrossRef

Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The autism diagnostic observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37, 613–627.PubMedCrossRef

Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 693–705.PubMedCrossRef

Hartley, S. L., & Sikora, D. M. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. Journal of Autism and Developmental Disorders, 39, 1715–1722.PubMedCrossRef

Holtman, M., Bolte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49, 361–366.CrossRef

Itsara, A., Wu, H., Smith, J. D., Nickerson, D. A., Romieu, I., London, S. J., et al. (2010). De novo rates and selection of large copy number variation. Genome Research, 20, 1469–1481.PubMedCrossRef

Jamain, S., Quach, H., Betancur, C., Rastam, M., Colineaux, C., Gillberg, I. C., et al. (2003). Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nature of Genetics, 34, 27–29.

Jones, M. B., Szatmari, P., & Piven, J. (1996). Nonfamiliality of the sex ratio in autism. American Journal of Medical Genetics, 67, 499–500.PubMedCrossRef

Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.

Kim, S. H., & Lord, C. (2012). Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to 47 months of age. Journal of Child Psychology and Psychiatry, 53(2), 143–151.PubMedCrossRef

Kopp, S., & Gillberg, C. (1992). Girls with social deficits and learning problems: Autism, atypical Aspergers syndrome, or a variant of these conditions. European Child and Adolescent Psychiatry, 1, 89–99.CrossRef

Landa, R., & Garrett-Mayer, E. (2006). Development in infants with autism spectrum disorders: A prospective study. Journal of Child Psychology and Psychiatry, 47, 629–638.PubMedCrossRef

LaSalle, J. M., & Yasui, D. H. (2009). Evolving role of MeCP2 in Rett syndrome and autism. Epigenomics, 1, 119–130.PubMedCrossRef

Lord, C., & Schopler, E. (1985). Differences in sex ratios in autism as a function of measured intelligence. Journal of Autism and Developmental Disorders, 15, 185–193.PubMedCrossRef

Lord, C., Schopler, E., & Revicki, D. (1982). Sex differences in autism. Journal of Autism and Developmental Disorders, 12, 317–330.PubMedCrossRef

Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., et al. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212.PubMedCrossRef

Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRef

Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006). Autism from 2 to 9 years of age. Archives of General Psychiatry, 63, 694–701.PubMedCrossRef

Lotter, V. (1966). Epidemiology of autistic conditions in young children, I. Prevalence. Social Psychiatry, 1, 124–137.CrossRef

Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2011). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-011-1356-0.

Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., et al. (2008). Structural variation of chromosomes in autism spectrum disorder. American Journal of Human Genetics, 82, 477–488.PubMedCrossRef

McLennan, J. D., Lord, C., & Schopler, E. (1993). Sex differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23, 217–227.PubMedCrossRef

Mullen, E. (1995). Mullen Scales of early learning. Circle Pines, MN: American Guidance Service, Inc.

Nichols, S., Moravcik, G., & Tetenbaum, S. P. (2008). Girls growing up on the autism spectrum: What parents and professionals should know about the pre-teen and teenage years. London: Jessica Kingsley Publishers.

Noor, A., Whibley, A., Marshall, C. R., Gianakopoulos, P. J., Piton, A., Carson, A. R., et al. (2010). Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Science Translational Medicine, 2, 49ra68.

Nyden, A., Hjelmquist, E., & Gillberg, C. (2000). Autism spectrum and attention-deficit disorders in girls. Some neuropsychological aspects. European Child and Adolescent Psychiatry, 9, 180–185.PubMedCrossRef

Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128, e488–e495.PubMed

Pilowsky, T., Yirmiya, N., Shulman, C., & Dover, R. (1998). The autism diagnostic interview-revised and the Childhood Autism Rating Scale: Differences between diagnostic systems and comparison between genders. Journal of Autism and Developmental Disorders, 28, 143–151.PubMedCrossRef

Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., et al. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466, 368–372.PubMedCrossRef

Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., et al. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1094–1103.PubMedCrossRef

Ritvo, E. R., Jorde, L. B., Mason-Brothers, A., Freeman, B. J., Pingree, C., Jones, M. B., et al. (1989). The UCLA-University of Utah epidemiologic survey of autism: Recurrence risk estimates and genetic counseling. American Journal of Psychiatry, 146, 1032–1036.PubMed

Rogers, S. J., Wehner, D. E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioural Pediatrics, 22, 409–417.CrossRef

Roid, G. H. (2003). Stanford-Binet Intelligence Scales (5th ed.). Itasca, IL: Riverside Publishing.

Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103.PubMedCrossRef

Scott, F. J., Baron-Cohen, S., Bolton, P., & Brayne, C. (2002). Brief report: prevalence of autism spectrum conditions in children aged 5–11 years in Cambridgeshire, UK. Autism, 6, 231–237.PubMedCrossRef

Skuse, D. H. (2000). Imprinting, the X-chromosome, and the male brain: Explaining sex differences in the liability to autism. Pediatric Research, 47, 9–16.PubMedCrossRef

Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (1984). Vineland adaptive behaviour scales (2nd ed.). Circle Pines, MN: American Guidance Service, Inc.

Spiker, D., Lotspeich, L. J., Dimiceli, S., Szatmari, P., Myers, R. M., & Risch, N. (2001). Birth order effects on nonverbal IQ scores in autism multiplex families. Journal of Autism and Developmental Disorders, 31, 449–460.PubMedCrossRef

Sumi, S., Taniai, H., Miyachi, T., & Tanemura, M. (2006). Sibling risk of pervasive developmental disorder estimated by means of an epidemiologic survey in Nagoya, Japan. Journal of Human Genetics, 51, 518–522.PubMedCrossRef

Szatmari, P. (1999). Heterogeneity and the genetics of autism. Journal of Psychiatry and Neurosciences, 24, 159–165.

Szatmari, P., Jones, M. B., Holden, J., Bryson, S., Mahoney, W., Tuff, L., et al. (1996). High phenotypic correlations among siblings with autism and pervasive developmental disorders. American Journal of Medical Genetics, 67, 354–360.PubMedCrossRef

Tsai, L. Y., & Beisler, J. M. (1983). The development of sex differences in infantile autism. British Journal of Psychiatry, 142, 373–378.PubMedCrossRef

Ventola, P. E., Kleinman, J., Pandey, J., Barton, M., Allen, S., Green, J., et al. (2006). Agreement among four diagnostic instruments for autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 36, 839–847.PubMedCrossRef

Vincent, J. B., Kolozsvari, D., Roberts, W. S., Bolton, P. F., Gurling, H. M., & Scherer, S. W. (2004). Mutation screening of X-chromosomal neuroligin genes: No mutations in 196 autism probands. American Journal of Medical Genetics (Neuropsychiatric Genetics), 129B, 82–84.CrossRef

Volkmar, F. R., Szatmari, P., & Sparrow, S. S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23, 579–591.PubMedCrossRef

Wing, L. (1981). Sex ratios in early childhood autism and related conditions. Psychiatry Research, 5, 129–137.PubMedCrossRef

Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. Journal of the American Medical Association, 289, 49–55.PubMedCrossRef

Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neurosciences, 23, 143–152.CrossRef

Zwaigenbaum, L., Bryson, S., Lord, C., Rogers, S., Carter, A., Carver, L., et al. (2009). Clinical assessment and management of toddlers with suspected autism spectrum disorder: Insights from studies of high-risk infants. Pediatrics, 123, 1383–1391.PubMedCrossRef

Titel: Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort
Auteurs: Lonnie Zwaigenbaum
Susan E. Bryson
Peter Szatmari
Jessica Brian
Isabel M. Smith
Wendy Roberts
Tracy Vaillancourt
Caroline Roncadin
Publicatiedatum: 01-12-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1515-y

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