Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-07-2012 | Original Paper

Behavioral Correlates of Maternal Antibody Status Among Children with Autism

Auteurs: Daniel Braunschweig, Paul Duncanson, Robert Boyce, Robin Hansen, Paul Ashwood, Isaac N. Pessah, Irva Hertz-Picciotto, Judy Van de Water

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

vorige artikel The Use of Skilled Strategies in Social Interactions by Groups High and Low in Self-Reported Social Skill

volgende artikel Emotion, Intent and Voluntary Movement in Children with Autism. An Example: The Goal Directed Locomotion

Abrahams, B. S., & Geschwind, D. H. (2008). Advances in autism genetics: On the threshold of a new neurobiology. Nature Reviews Genetics, 9(5), 341–355.PubMedCrossRef

APA. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV text revision. Washington, DC: American Psychiatric Association.

Atladottir, H. O., Pedersen, M. G., Thorsen, P., Mortensen, P. B., Deleuran, B., Eaton, W. W., et al. (2009). Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics, 124(2), 687–694.PubMedCrossRef

Boulanger, L. M., & Shatz, C. J. (2004). Immune signalling in neural development, synaptic plasticity and disease. Nature Reviews Neuroscience, 5(7), 521–531.PubMedCrossRef

Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L. A., et al. (2008). Autism: Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology, 29(2), 226–231.PubMed

Cabanlit, M., Wills, S., Goines, P., Ashwood, P., & Van de Water, J. (2007). Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Annals of the New York Academy of Sciences, 1107, 92–103.PubMedCrossRef

Croen, L. A., Braunschweig, D., Haapanen, L., Yoshida, C. K., Fireman, B., Grether, J. K., et al. (2008). Maternal mid-pregnancy autoantibodies to fetal brain protein: The early markers for autism study. Biological Psychiatry, 64(7), 583–588.PubMedCrossRef

Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., et al. (2003). Maternal neuronal antibodies associated with autism and a language disorder. Annals of Neurology, 53(4), 533–537.PubMedCrossRef

Edinburgh. (2000). www.cgmh.org.tw/intr/intr1/c0040/web/C/Declaration%20of%20Helsinki.pdf.

Garty, B. Z., Ludomirsky, A., Danon, Y. L., Peter, J. B., & Douglas, S. D. (1994). Placental transfer of immunoglobulin G subclasses. Clinical and Diagnostic Laboratory Immunology, 1(6), 667–669.PubMed

Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., et al. (2008). Regression in autism: Prevalence and associated factors in the CHARGE Study. Ambulatory Pediatrics, 8(1), 25–31.PubMedCrossRef

Harris, N. L., Spoerri, I., Schopfer, J. F., Nembrini, C., Merky, P., Massacand, J., et al. (2006). Mechanisms of neonatal mucosal antibody protection. Journal of Immunology, 177(9), 6256–6262.

Hertz-Picciotto, I., Croen, L. A., Hansen, R., Jones, C. R., van de Water, J., & Pessah, I. N. (2006). The CHARGE study: An epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives, 114(7), 1119–1125.PubMedCrossRef

Joseph, R. M., Tager-Flusberg, H., & Lord, C. (2002). Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 43(6), 807–821.PubMedCrossRef

Kogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., et al. (2009). Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007. Pediatrics.

Kvetny, J., & Poulsen, H. (2006). Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. The Journal of Maternal-Fetal & Neonatal Medicine, 19(12), 817–822.

Lee, J. Y., Huerta, P. T., Zhang, J., Kowal, C., Bertini, E., Volpe, B. T., et al. (2009). Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nature Medicine, 15, 91–96.PubMedCrossRef

Lord, C., Pickles, A., McLennan, J., Rutter, M., Bregman, J., Folstein, S., et al. (1997). Diagnosing autism: Analyses of data from the autism diagnostic interview. Journal of Autism and Developmental Disorders, 27(5), 501–517.PubMedCrossRef

Malek, A., Sager, R., Kuhn, P., Nicolaides, K. H., & Schneider, H. (1996). Evolution of maternofetal transport of immunoglobulins during human pregnancy. American Journal of Reproductive Immunology, 36(5), 248–255.PubMedCrossRef

Martin, L. A., Ashwood, P., Braunschweig, D., Cabanlit, M., Van de Water, J., & Amaral, D. G. (2008). Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain, Behavior, and Immunity, 22(6), 806–816.PubMedCrossRef

Mullen, E. (Ed.). (1995). Mullen scale of early learning. Circle Pines, MN: American Guidance Service.

Simister, N. E. (2003). Placental transport of immunoglobulin G. Vaccine, 21(24), 3365–3369.PubMedCrossRef

Singer, H. S., Morris, C. M., Gause, C. D., Gillin, P. K., Crawford, S., & Zimmerman, A. W. (2008). Antibodies against fetal brain in sera of mothers with autistic children. Journal of Neuroimmunology, 194(1–2), 165–172.PubMedCrossRef

Singer, H. S., Morris, C., Gause, C., Pollard, M., Zimmerman, A. W., & Pletnikov, M. (2009). Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. Journal of Neuroimmunology, 211(1–2), 39–48.PubMedCrossRef

Sparrow, S. B., Balla, D. A., & Cicchetti, D. V. (1984). Vineland adaptive behavior scales survey form manual. Circle Pines, MN: American Guidance Service.

Steinhausen, H. C., & Erdin, A. (1992). Abnormal psychosocial situations and ICD-10 diagnoses in children and adolescents attending a psychiatric service. Journal of Child Psychology and Psychiatry, 33(4), 731–740.PubMedCrossRef

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., et al. (2007). The classical complement cascade mediates CNS synapse elimination. Cell, 131(6), 1164–1178.PubMedCrossRef

Taniai, H., Nishiyama, T., Miyachi, T., Imaeda, M., & Sumi, S. (2008). Genetic influences on the broad spectrum of autism: Study of proband-ascertained twins. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147B(6), 844–849.CrossRef

Tincani, A., Rebaioli, C. B., Taglietti, M., & Shoenfeld, Y. (2006). Heart involvement in systemic lupus erythematosus anti-phospholipid syndrome and neonatal lupus. Rheumatology (Oxford), 454, iv8–iv13.CrossRef

Warren, R. P., Cole, P., Odell, J. D., Pingree, C. B., Warren, W. L., White, E., et al. (1990). Detection of maternal antibodies in infantile autism. Journal of the American Academy of Child and Adolescent Psychiatry, 29(6), 873–877.PubMedCrossRef

WHO. (1992). ICD-10: International statistical calssification of diseases and related health problems, 10th Revision. Geneva: World Health Organization.

Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L. C., Singer, H. S., Castaneda, J. A., et al. (2007). Maternal antibrain antibodies in autism. Brain, Behavior, and Immunity, 21(3), 351–357.PubMedCrossRef

Titel: Behavioral Correlates of Maternal Antibody Status Among Children with Autism
Auteurs: Daniel Braunschweig
Paul Duncanson
Robert Boyce
Robin Hansen
Paul Ashwood
Isaac N. Pessah
Irva Hertz-Picciotto
Judy Van de Water
Publicatiedatum: 01-07-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1378-7

Andere artikelen Uitgave 7/2012

Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders

Original Paper

Brief Report: Selective Social Anhedonia in High Functioning Autism

Brief Report

The Prevalence of Autism Spectrum Disorders in Toddlers: A Population Study of 2-Year-Old Swedish Children

Original Paper

Moral and Social Reasoning in Autism Spectrum Disorders

Original Paper

Clinical and Laboratory Data in a Sample of Greek Children with Autism Spectrum Disorders

Original Paper

Sex Differences in Autism Spectrum Disorder: Evidence from a Large Sample of Children and Adolescents

Original Paper