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Journal of Autism and Developmental Disorders

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Gepubliceerd in:

01-07-2012 | Original Paper

Behavioral Correlates of Maternal Antibody Status Among Children with Autism

Auteurs: Daniel Braunschweig, Paul Duncanson, Robert Boyce, Robin Hansen, Paul Ashwood, Isaac N. Pessah, Irva Hertz-Picciotto, Judy Van de Water

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

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Titel: Behavioral Correlates of Maternal Antibody Status Among Children with Autism
Auteurs: Daniel Braunschweig
Paul Duncanson
Robert Boyce
Robin Hansen
Paul Ashwood
Isaac N. Pessah
Irva Hertz-Picciotto
Judy Van de Water
Publicatiedatum: 01-07-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1378-7

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