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Gepubliceerd in: Child Psychiatry & Human Development 6/2015

10-02-2015 | Substantive/Theoretical Review

Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?

Auteurs: Michelle L. Byrne, Neil M. O’Brien-Simpson, Sarah A. Mitchell, Nicholas B. Allen

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 6/2015

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Abstract

Depression often has its first onset during adolescence and is associated with obesity. Furthermore, inflammatory processes have been implicated in both depression and obesity, although research amongst adolescents is limited. This review explores associations between depression and obesity, depression and inflammation, and obesity and inflammation from a developmental perspective. The temporal relations between these factors are examined to explore whether obesity and elevated inflammation act as either risk factors for, or outcomes of, adolescent-onset depression. Sex differences in these processes are also summarized. We propose a model whereby increases in sex hormones during puberty increase risk for depression for females, which can lead to obesity, which in turn increases levels of inflammation. Importantly, this model suggests that inflammation and obesity are outcomes of adolescent depression, rather than initial contributing causes. Further research on biological and psychosocial effects of sex hormones is needed, as is longitudinal research with children and adolescents.
vorige artikel A Developmental Perspective on Peer Rejection, Deviant Peer Affiliation, and Conduct Problems Among Youth
volgende artikel Using a Brief Parent-Report Measure to Track Outcomes for Children and Teens with Internalizing Disorders
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Metagegevens
Titel
Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?
Auteurs
Michelle L. Byrne
Neil M. O’Brien-Simpson
Sarah A. Mitchell
Nicholas B. Allen
Publicatiedatum
10-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 6/2015
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-014-0524-9

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