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Research on Child and Adolescent Psychopathology

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01-02-2013

5-HTTLPR X Stress in Adolescent Depression: Moderation by MAOA and Gender

Auteurs: Heather A. Priess-Groben, Janet Shibley Hyde

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 2/2013

Abstract

Depression surges in adolescence, especially among girls. Most evidence indicates that the short allele of a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) interacts with stress to influence the onset of depression. This effect appears to be less robust in adolescents, particularly among boys, and may be moderated by other genetic polymorphisms. Seeking to explain the adolescent gender difference in depression, this study examined the effects of 5-HTTLPR (rs25531), the monoamine oxidase A-upstream variable number tandem repeat (MAOA-uVNTR), and negative life events (NLE). A community-based longitudinal sample of 309 adolescents reported depressive symptoms and NLE at ages 11, 13, and 15. 5-HTTLPR and MAOA-uVNTR genotypes were ascertained via buccal swabs. A significant four-way interaction of 5-HTTLPR, MAOA-uVNTR, NLE at age 13, and gender predicted depressive symptoms at age 15. Girls were most likely to exhibit elevated depressive symptoms when experiencing NLE if they possessed low-expression MAOA-uVNTR alleles and short 5-HTTLPR alleles, whereas low-expression MAOA-uVNTR alleles but long 5-HTTLPR alleles were implicated in boys. The results indicate that the commonly reported 5-HTTLPR by stress interaction for depression may be limited to individuals with low-expression MAOA-uVNTR alleles. These data also provide new evidence that the short allele of 5-HTTLPR confers susceptibility to stress differently for females compared with males.

vorige artikel Early Negative Affect Predicts Anxiety, not Autism, in Preschool Boys with Fragile X Syndrome

volgende artikel Pathways From Depressive Symptoms to Low Social Status

Given that only girls can be heterozygous for MAOA-uVNTR, we cannot analyze these girls in a model that also contains boys. However, when we analyzed girls separately and included heterozygous girls (increasing the sample size by 48), our finding remained unchanged. That is, the interaction of 5-HTTLPR and NLE held only for girls homozygous for low-expression MAOA alleles.

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Titel: 5-HTTLPR X Stress in Adolescent Depression: Moderation by MAOA and Gender
Auteurs: Heather A. Priess-Groben
Janet Shibley Hyde
Publicatiedatum: 01-02-2013
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 2/2013
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-012-9672-1

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