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Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

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Abstract

Serotonin plays a central role in mood regulation and the development of depressive disorders. The present study investigated whether a functional polymorphism (5HTTLPR) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. A cohort of 17–18 years old students (n = 1,482) anonymously completed the Survey of Adolescent Life and Health in Vestmanland 2006 and gave a saliva sample for DNA extraction. An association between maltreatment and adolescent depression was found independent of sex. When the whole population was analyzed, no main effect of 5HTTLPR in association with depression was found. When separated by sex, a significant main effect and a G × E interaction effect of the SS allele was found among girls. No gene main effect or G × E interaction effect was found among boys. The present study confirms previous findings of sex differences in interaction effects between the 5HTTLPR polymorphism and maltreatment in the prediction of adolescent depression.

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Acknowledgments

Grants from the following funds and organizations are acknowledged: The Uppsala and Örebro Regional Research Council, Fredrik and Ingrid Thurings Foundation, the County Council of Västmanland, Swedish Prison and Probation Service/Scientific Advisory Board, Swedish Research Council (VR), AFA Insurance, and Systembolagets Råd för Alkoholforskning (SRA). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.

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Authors and Affiliations

  1. Centre for Clinical Research, Central Hospital, Uppsala University, 72189, Västerås, Sweden

    Cecilia Åslund, Jerzy Leppert, Erika Comasco & Kent W. Nilsson

  2. Department of Neuroscience, Unit of Pharmacology, Uppsala University, 75105, Uppsala, Sweden

    Erika Comasco, Niklas Nordquist & Lars Oreland

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  1. Cecilia Åslund
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  2. Jerzy Leppert
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  3. Erika Comasco
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  4. Niklas Nordquist
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  5. Lars Oreland
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  6. Kent W. Nilsson
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Correspondence to Cecilia Åslund.

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Edited by Peter McGuffin.

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Åslund, C., Leppert, J., Comasco, E. et al. Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study. Behav Genet 39, 524–531 (2009). https://doi.org/10.1007/s10519-009-9285-9

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  • DOI: https://doi.org/10.1007/s10519-009-9285-9

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