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Previous studies have documented the primarily genetic aetiology for the stronger phenotypic covariance between reading disability and ADHD inattention symptoms, compared to hyperactivity-impulsivity symptoms. In this study, we examined to what extent this covariation could be attributed to “generalist genes” shared with general cognitive ability or to “specialist” genes which may specifically underlie processes linking inattention symptoms and reading difficulties. We used multivariate structural equation modeling on IQ, parent and teacher ADHD ratings and parent ratings on reading difficulties from a general population sample of 1312 twins aged 7.9–10.9 years. The covariance between reading difficulties and ADHD inattention symptoms was largely driven by genetic (45%) and child-specific environment (21%) factors not shared with IQ and hyperactivity-impulsivity; only 11% of the covariance was due to genetic effects common with IQ. Aetiological influences shared among all phenotypes explained 47% of the variance in reading difficulties. The current study, using a general population sample, extends previous findings by showing, first, that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genes contributing to general cognitive ability and, second, that child-specific environment factors, independent from IQ, also contribute to the covariation between reading difficulties and inattention symptoms.
Alarcon, M., & DeFries, J. C. (1997). Reading performance and general cognitive ability in twins with reading difficulties and control pairs. Personality and Individual Differences, 22(6), 793–803. CrossRef
American Psychiatric Association (APA). (2000). Diagnostic and statistical manual of mental disorders, 4 edition, text revision (4th ed.). Washington: APA. CrossRef
Astrom, R., DeFries, J. C., Pennington, B., Wadsworth, S., & Willcutt, E. G. (2009). Etiology of covariation between a parent-report screening measure and reading performance. Behavior Genetics, 39(6), 634.
Byrne, B., Coventry, W. L., Olson, R. K., Hulslander, J., Wadsworth, S., DeFries, J. C., et al. (2008). A behaviour-genetic analysis of orthographic learning, spelling and decoding. Journal of Research in Reading, 31(1), 8–21. CrossRef
Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., et al. (2008). DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(8), 1450–1460. CrossRef
Conners, C. K. (1997). Conners’ Rating Scales-Revised. Technical Manual. New York: MHS.
de Jong, C. G., Van De Voorde, S., Roeyers, H., Raymaekers, R., Allen, A. J., Knijff, S., et al. (2009). Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. Journal of Child and Adolescent Psychopharmacology, 19(6), 699–707. CrossRefPubMed
Fantuzzo, J., Bulotsky, R., McDermott, P., Mosca, S., & Lutz, M. N. (2003). A multivariate analysis of emotional and behavioral adjustment and preschool educational outcomes. School Psychology Review, 32(2), 185–203.
Faraone, S. V., Biederman, J., Lehman, B. K., Keenan, K., Norman, D., Seidman, L. J., et al. (1993). Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities: results from a family genetic study. The American Journal of Psychiatry, 150(6), 891–895. PubMed
Fergusson, D. M., & Horwood, L. J. (1992). Attention-deficit and reading-achievement. Journal of Child Psychology and Psychiatry and Allied Disciplines, 33(2), 375–385. CrossRef
Friedman, M. C., Chhabildas, N., Budhiraja, N., Willcutt, E. G., & Pennington, B. F. (2003). Etiology of the comorbidity between RD and ADHD: exploration of the non-random mating hypothesis. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 120B(1), 109–115. CrossRef
Harlaar, N., Hayiou-Thomas, M. E., & Plomin, R. (2005a). Reading and general cognitive ability: a multivariate analysis of 7-year-old twins. Scientific Studies of Reading, 9(3), 197–218. CrossRef
Harlaar, N., Spinath, F. M., Dale, P. S., & Plomin, R. (2005b). Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins. Journal of Child Psychology and Psychiatry, 46(4), 373–384. CrossRef
Haworth, C. M., Kovas, Y., Harlaar, N., Hayiou-Thomas, M. E., Petrill, S. A., Dale, P. S., et al. (2009). Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins. Journal of Child Psychology and Psychiatry, 50(10), 1318–1325. CrossRefPubMed
Horn, W. F., & Packard, T. (1985). Early identification of learning-problems—a meta-analysis. Journal of Education & Psychology, 77(5), 597–607. CrossRef
Hottenga, J., & Boomsma, D. I. (2008). QTL detection in multivariate data from sibling pairs. In B. Neale, M. A. Ferreira, S. E. Medland, & D. Posthuma (Eds.), Statistical genetics. Gene mapping through linkage and association (pp. 239–264). New York: Taylor & Francis.
Keulers, E. H., Hendriksen, J. G., Feron, F. J., Wassenberg, R., Wuisman-Frerker, M. G., Jolles, J., et al. (2007). Methylphenidate improves reading performance in children with attention deficit hyperactivity disorder and comorbid dyslexia: an unblinded clinical trial. European Journal of Paediatric Neurology, 11(1), 21–28. CrossRefPubMed
Kuntsi, J., Eley, T. C., Taylor, A., Hughes, C., Asherson, P., Caspi, A., et al. (2004). Co-occurrence of ADHD and low IQ has genetic origins. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 124B(1), 41–47. CrossRef
Loehlin, J. C. (1996). The Cholesky approach: a cautionary note. Behavior Genetics, 26(1), 65–69. CrossRef
Martin, N. C., Levy, F., Pieka, J., & Hay, D. A. (2006). A genetic study of attention deficit hyperactivity disorder, conduct disorder, oppositional defiant disorder and reading disability: aetiological overlaps and implications. International Journal of Disability, Development and Education, 53(1), 21–34. CrossRef
Marzocchi, G. M., Ornaghi, S., & Barboglio, S. (2009). What are the causes of the attention deficits observed in children with dyslexia? Child Neuropsychology, 15(6), 567–581. CrossRef
Neale, M. C., & Cardon, L. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic.
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statistical modeling (6th ed.). Richmond: Department of Psychiatry.
Neale, M. C., Roysamb, E., & Jacobson, K. (2006). Multivariate genetic analysis of sex limitation and G x E interaction. Twin Research and Human Genetics, 9(4), 481–489. PubMed
Newman, J., Noel, A., Chen, R., & Matsopoulos, A. S. (1998). Temperament, selected moderating variables and early reading achievement. Journal of School Psychology, 36(2), 215–232. CrossRef
Oliver, B., & Plomin, R. (2006). Twins’ Early Development Study (TEDS): a multivariate, longitudinal genetic Investigation of language, cognition and behavior Problems from childhood through adolescence. Twin Research and Human Genetics, 10(1), 96–105. CrossRef
Pennington, B., Groisser, D., & Welsh, M. C. (1993). Contrasting cognitive deficits in Attention Deficit Hyperactivity Disorder versus Reading Disability. Developmental Psychology, 29, 511–523. CrossRef
Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral Genetics (4th ed.). New York: Worth.
Rommelse, N. N., Altink, M. E., Fliers, E. A., Martin, N. C., Buschgens, C. J., Hartman, C. A., et al. (2009). Comorbid problems in ADHD: degree of association, shared endophenotypes, and formation of distinct subtypes. Implications for a future DSM. Journal of Abnormal Child Psychology, 37(6), 793–804. CrossRefPubMed
Sattler, J. M. (1992). Assessment of Children: WISC-III and WPPSI-R Supplement. San Diego: Jerome M. Sattler.
Saudino, K. J., Ronald, A., & Plomin, R. (2005). The etiology of behavior problems in 7-year-old twins: substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachers. Journal of Abnormal Child Psychology, 33(1), 113–130. CrossRefPubMed
Stage, S. A., Abbott, R. D., Jenkins, J. R., & Berninger, V. W. (2003). Predicting response to early reading intervention from verbal IQ, reading-related language abilities, attention ratings, and verbal IQ-word reading discrepancy: failure to validate discrepancy method. Journal of Learning Disabilities, 36(1), 24–33. CrossRefPubMed
Stuebing, K. K., Fletcher, J. M., LeDoux, J. M., Lyon, G. R., Shaywitz, S. E., & Shaywitz, B. A. (2002). Validity of IQ-discrepancy classifications of reading disabilities: a meta-analysis. American Educational Research Journal, 39(2), 469–518. CrossRef
Torgesen, J. K., Wagner, R. K., & Rashotte, C. A. (1999). Test of Word Reading Efficiency (TOWRE). Austin: Pro-ed.
Wagenmakers, E. J., & Farrell, S. (2004). AIC model selection using Akaike weights. Psychonomic Bulletin & Review, 11(1), 192–196.
Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). London: The Psychological Corporation.
Wigg, K. G., Feng, Y., Crosbie, J., Tannock, R., Kennedy, J. L., Ickowicz, A., et al. (2008). Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. Genes Brain and Behavior, 7(8), 877–886. CrossRef
Willcutt, E. G., Pennington, B. F., Smith, S. D., Cardon, L. R., Gayan, J., Knopik, V. S., et al. (2002). Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. American Journal of Medical Genetics, 114(3), 260–268. CrossRefPubMed
Willcutt, E. G., Betjemann, R. S., Wadsworth, S. J., Samuelsson, S., Corley, R., DeFries, J. C., et al. (2007a). Preschool twin study of the relation between attention-deficit/hyperactivity disorder and prereading skills. Reading and Writing, 20(1–2), 103–125.
Willcutt, E. G., Pennington, B. F., Olson, R. K., & DeFries, J. C. (2007b). Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 144B(6), 709–714. CrossRef
Willcutt, E. G., Betjemann, R. S., McGrath, L. M., Chhabildas, N., Olson, R., DeFries, J. C., et al. (2010a). Etiology and neuropsychology of comorbidity between RD and ADHD: the case for multiple deficit models. (Under review).
Willcutt, E. G., Boada, R., Riddle, M., Chhabildas, N., DeFries, J. C., & Pennington, B. (2010b). Colorado Learning Difficulties Questionnaire: Validation of a parent-report screening measure. (Under review).
Wood, A. C., Asherson, P., van der Meere, J. J., & Kuntsi, J. (2009). Separation of genetic influences on attention deficit hyperactivity disorder symptoms and reaction time performance from those on IQ. Psychological Medicine, Published online 15 September 2009, DOI: 2010.1017/S003329170999119X.
- The Genetic Association Between ADHD Symptoms and Reading Difficulties: The Role of Inattentiveness and IQ
Alexis C. Wood
- Springer US