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01-05-2009 | Original Paper

Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy

Auteurs: Manuel F. Casanova, Ayman El-Baz, Meghan Mott, Glenn Mannheim, Hossam Hassan, Rachid Fahmi, Jay Giedd, Judith M. Rumsey, Andrew E. Switala, Aly Farag

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2009

Abstract

Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients.

vorige artikel Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

volgende artikel Factor Analytic Study of Repetitive Behaviours in Young Children with Pervasive Developmental Disorders

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Titel: Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy
Auteurs: Manuel F. Casanova
Ayman El-Baz
Meghan Mott
Glenn Mannheim
Hossam Hassan
Rachid Fahmi
Jay Giedd
Judith M. Rumsey
Andrew E. Switala
Aly Farag
Publicatiedatum: 01-05-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0681-4

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Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy

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