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01-02-2014 | Artikel

Rattenseks als model voor complex seksueel gedrag van mensen

Auteurs: Elisabeth Bijlsma, Jan Veening, Ronald Oosting, Marcel D. Waldinger, Berend Olivier

Gepubliceerd in: Neuropraxis | Uitgave 1/2014

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Samenvatting

Seksueel gedrag is een complex fenomeen dat beïnvloed wordt door veel verschillende factoren en sterk gereguleerd wordt door neurobiologische processen. Deze bijdrage geeft, aan de hand van een aantal actuele voorbeelden, een beeld van de translationele waarde van onderzoek bij ratten voor het bestuderen van de neurobiologische regulatie van seksueel gedrag en de verstoringen daarin bij verschillende seksuele dysfuncties. De besproken voorbeelden laten zien dat met name onderzoek naar remmende en stimulerende effecten van verschillende farmaca bij mannelijke ratten goed aansluit bij bevindingen in mensen. Bij vrouwelijke ratten corresponderen sommige farmacologische effecten goed met die bij mensen; andere doen dat echter niet. Dit is wellicht te verklaren doordat er nog niet genoeg inzicht is in welke gedragsmaten in vrouwelijke ratten representatief zijn voor vrouwelijk seksueel gedrag in mensen.
Literatuur
1.
go back to reference Waldinger, M.D. (2002). The neurobiological approach to premature ejaculation. The journal of urology, 168, 2359–2367.PubMedCrossRef Waldinger, M.D. (2002). The neurobiological approach to premature ejaculation. The journal of urology, 168, 2359–2367.PubMedCrossRef
2.
go back to reference Waldinger, M.D., Hengeveld, M.W., Zwinderman, A.H. & Olivier B. (1998). Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. Journal of clinical psychopharmacology, 18, 274–281.PubMedCrossRef Waldinger, M.D., Hengeveld, M.W., Zwinderman, A.H. & Olivier B. (1998). Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. Journal of clinical psychopharmacology, 18, 274–281.PubMedCrossRef
3.
go back to reference Agmo, A. (2007). Functional and dysfunctional sexual behavior: a synthesis of neuroscience and comparative psychology. 1st Ed. Academic Press. Agmo, A. (2007). Functional and dysfunctional sexual behavior: a synthesis of neuroscience and comparative psychology. 1st Ed. Academic Press.
4.
go back to reference Waldinger, M.D. (2003). Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. International journal of impotence research, 15, 309–313.PubMedCrossRef Waldinger, M.D. (2003). Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. International journal of impotence research, 15, 309–313.PubMedCrossRef
5.
go back to reference Pattij, T., Jong, T.R. de, Uitterdijk, A., Waldinger, M.D., Veening, J.G., Cools, A.R., et al. (2005). Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. The European journal of neuroscience, 22, 724–734. Pattij, T., Jong, T.R. de, Uitterdijk, A., Waldinger, M.D., Veening, J.G., Cools, A.R., et al. (2005). Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. The European journal of neuroscience, 22, 724–734.
6.
go back to reference Rosen, R.C., Lane, R.M. & Menza, M. (1999). Effects of SSRI’s on sexual function: a critical review. Journal of clinical psychopharmacology, 19, 67–85.PubMedCrossRef Rosen, R.C., Lane, R.M. & Menza, M. (1999). Effects of SSRI’s on sexual function: a critical review. Journal of clinical psychopharmacology, 19, 6785.PubMedCrossRef
7.
go back to reference Bijlsma, E.Y., Chan, J.S., Olivier, B., Veening, J.G., Millan, M.J., Waldinger, M.D., et al. (2013). Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release? Pharmacology, biochemistry, and behavior. Bijlsma, E.Y., Chan, J.S., Olivier, B., Veening, J.G., Millan, M.J., Waldinger, M.D., et al. (2013). Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release? Pharmacology, biochemistry, and behavior.
8.
go back to reference Olivier, J.D., Jong, T.R. de, Jos Dederen, P., Oorschot, R. van, Heeren, D., Pattij, T., et al. (2007). Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat. European journal of pharmacology, 576, 61–76. Olivier, J.D., Jong, T.R. de, Jos Dederen, P., Oorschot, R. van, Heeren, D., Pattij, T., et al. (2007). Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat. European journal of pharmacology, 576, 61–76.
9.
go back to reference Georgiadis, J.R., Kringelbach, M.L. & Pfaus, J.G. (2012). Sex for fun: a synthesis of human and animal neurobiology. Nature reviews urology, 9, 486–498.PubMedCrossRef Georgiadis, J.R., Kringelbach, M.L. & Pfaus, J.G. (2012). Sex for fun: a synthesis of human and animal neurobiology. Nature reviews urology, 9, 486–498.PubMedCrossRef
10.
go back to reference Janssen, P.K., Bakker, S.C., Rethelyi, J., Zwinderman, A.H., Touw, D.J., Olivier, B., et al. (2009). Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. The journal of sexual medicine, 6, 276–284. Janssen, P.K., Bakker, S.C., Rethelyi, J., Zwinderman, A.H., Touw, D.J., Olivier, B., et al. (2009). Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. The journal of sexual medicine, 6, 276–284.
11.
go back to reference Smits, B.M., Mudde, J.B, Belt, J. van de, Verheul, M., Olivier, J., Homberg, J., et al. (2006). Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenetics and genomics, 16, 159–169. Smits, B.M., Mudde, J.B, Belt, J. van de, Verheul, M., Olivier, J., Homberg, J., et al. (2006). Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenetics and genomics, 16, 159–169.
12.
go back to reference Homberg, J.R., Olivier, J.D., Smits, B.M., Mul, J.D., Mudde, J., Verheul, M., et al. 2007. Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience, 146, 1662–1676.PubMedCrossRef Homberg, J.R., Olivier, J.D., Smits, B.M., Mul, J.D., Mudde, J., Verheul, M., et al. 2007. Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience, 146, 1662–1676.PubMedCrossRef
13.
go back to reference Chan, J.S.W, Snoeren, E.M.S., Cuppen, E., Waldinger, M.D., Olivier, B. & Oosting, R.S. (2010). The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. Journal of sexual medicine, in druk. Chan, J.S.W, Snoeren, E.M.S., Cuppen, E., Waldinger, M.D., Olivier, B. & Oosting, R.S. (2010). The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. Journal of sexual medicine, in druk.
14.
go back to reference Snoeren, E., Chan, J., Bovens, A., Cuppen, E., Waldinger, M., Olivier, B., et al. (2010). Serotonin Transporter Null Mutation and Sexual Behavior in Female Rats: 5-HT1A Receptor Desensitization. The journal of sexual medicine, 7, 2424–2434.PubMed Snoeren, E., Chan, J., Bovens, A., Cuppen, E., Waldinger, M., Olivier, B., et al. (2010). Serotonin Transporter Null Mutation and Sexual Behavior in Female Rats: 5-HT1A Receptor Desensitization. The journal of sexual medicine, 7, 2424–2434.PubMed
15.
go back to reference Poels, S., Bloemers, J., Rooij, K. van, Goldstein, I., Gerritsen, J., Ham, D. van, et al. (2013). Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. The journal of sexual medicine, 10, 810–823. Poels, S., Bloemers, J., Rooij, K. van, Goldstein, I., Gerritsen, J., Ham, D. van, et al. (2013). Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. The journal of sexual medicine, 10, 810–823.
16.
go back to reference Snoeren, E.M., Bovens, A., Refsgaard, L.K., Westphal, K.G., Waldinger, M.D., Olivier, B., et al. (2011a). Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats. The journal of sexual medicine, 8, 989–1001.PubMedCrossRef Snoeren, E.M., Bovens, A., Refsgaard, L.K., Westphal, K.G., Waldinger, M.D., Olivier, B., et al. (2011a). Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats. The journal of sexual medicine, 8, 989–1001.PubMedCrossRef
17.
go back to reference Snoeren, E.M., Refsgaard, L.K., Waldinger, M.D., Olivier, B. & Oosting, R.S. (2011b). Chronic paroxetine treatment does not affect sexual behavior in hormonally sub-primed female rats despite 5-HT(1)(A) receptor desensitization. The journal of sexual medicine, 8, 976–988.PubMedCrossRef Snoeren, E.M., Refsgaard, L.K., Waldinger, M.D., Olivier, B. & Oosting, R.S. (2011b). Chronic paroxetine treatment does not affect sexual behavior in hormonally sub-primed female rats despite 5-HT(1)(A) receptor desensitization. The journal of sexual medicine, 8, 976–988.PubMedCrossRef
Metagegevens
Titel
Rattenseks als model voor complex seksueel gedrag van mensen
Auteurs
Elisabeth Bijlsma
Jan Veening
Ronald Oosting
Marcel D. Waldinger
Berend Olivier
Publicatiedatum
01-02-2014
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 1/2014
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-014-0037-0

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