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01-02-2014 | Artikel

Een vernieuwende farmacotherapeutische behandeling voor vrouwen met hypoactive sexual desire disorder

Auteurs: Saskia Poels, Jos Bloemers, Kim van Rooij, Hans Koppeschaar, Berend Olivier, Adriaan Tuiten

Gepubliceerd in: Neuropraxis | Uitgave 1/2014

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Samenvatting

Verminderd seksueel verlangen is de meest voorkomende seksuele klacht bij vrouwen. Dit kan seksuele ontevredenheid veroorzaken, wat een negatieve invloed kan hebben op de kwaliteit van leven. Deze klachten zijn in de DSM-IV geclassificeerd als de diagnose Hypoactive Sexual Desire Disorder (HSDD) en sinds kort ondergebracht in de nieuwe diagnose Female Sexual Interest/Arousal Disorder (FSIAD) in de DSM-5. Op dit moment is er nog geen goedgekeurde medicamenteuze behandeling beschikbaar voor vrouwen met HSDD (FSIAD) terwijl er wel grote behoefte aan is. In onze zoektocht naar adequate medische behandelingsmogelijkheden hebben wij een andere wetenschappelijke aanpak gevolgd dan de grote farmaceutische bedrijven. Op basis van een personalized sexual medicine approach hebben we eerst vastgesteld dat er tussen vrouwen verschillen bestaan in oorzakelijke mechanismen die ten grondslag kunnen liggen aan de seksuele klachten. Dit leidde tot twee onderscheidende mechanismen: een ongevoelig systeem voor seksuele stimuli en een overactief seksueel remsysteem. Gebaseerd op deze onderliggende oorzaken van HSDD zijn twee nieuwe on-demand medicamenteuze behandelingen ontwikkeld. De ene behandeling (testosteron gecombineerd met een fosfodiësterase-type-5-remmer) is ontwikkeld voor vrouwen die lijden aan HSDD als gevolg van een relatief ongevoelig systeem voor seksuele prikkels, terwijl de andere behandeling (testosteron gecombineerd met een 5-HT1A -receptoragonist) is ontwikkeld voor vrouwen die lijden aan HSDD als gevolg van overmatige activatie van het seksuele remsysteem.
Literatuur
1.
go back to reference Aleman, A., Bronk, E., Kessels, R.P., Koppeschaar, H.P., Honk J. van (2004). A single administration of testosterone improves visuospatial ability in young women. Psychoneuroendocrinology, 29, 612–617. Aleman, A., Bronk, E., Kessels, R.P., Koppeschaar, H.P., Honk J. van (2004). A single administration of testosterone improves visuospatial ability in young women. Psychoneuroendocrinology, 29, 612–617.
2.
go back to reference American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders. Text Revision. Fourth ed. Washington, DC: American Psychiatric Association;. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders. Text Revision. Fourth ed. Washington, DC: American Psychiatric Association;.
3.
go back to reference American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. Fifth ed. Washington, DC: American Psychiatric Association. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. Fifth ed. Washington, DC: American Psychiatric Association.
4.
go back to reference Anders, S.M. van, Hamilton, L.D., Schmidt, N. & Watson, N.V. (2007). Associations between testosterone secretion and sexual activity in women. Hormones and Behavior, 51, 477–482. Anders, S.M. van, Hamilton, L.D., Schmidt, N. & Watson, N.V. (2007). Associations between testosterone secretion and sexual activity in women. Hormones and Behavior, 51, 477–482.
5.
go back to reference Auger A. (2004). Steroid receptor control of reproductive behavior. Hormones and Behavior, 45, 168–72. Auger A. (2004). Steroid receptor control of reproductive behavior. Hormones and Behavior, 45, 168–72.
6.
go back to reference Baglietto, L., Severi, G., English, D.R., Krishnan, K., Hopper, J.L., McLean, C. et al. (2010). Circulating steroid hormone levels and risk of breast cancer for postmenopausal women. Cancer Epidemiology, Biomarkers and Prevention, 19, 492–502. Baglietto, L., Severi, G., English, D.R., Krishnan, K., Hopper, J.L., McLean, C. et al. (2010). Circulating steroid hormone levels and risk of breast cancer for postmenopausal women. Cancer Epidemiology, Biomarkers and Prevention, 19, 492–502.
7.
go back to reference Basson, R. & Brotto, L.A. (2003). Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial. BJOG, An International Journal of Obstetrics and Gyneacology, 110, 1014–1024. Basson, R. & Brotto, L.A. (2003). Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial. BJOG, An International Journal of Obstetrics and Gyneacology, 110, 1014–1024.
8.
go back to reference Beauregard, M., Levesque, J. & Bourgouin, P. (2001). Neural correlates of conscious self-regulation of emotion. The Journal of Neuroscience, 21, RC165. Beauregard, M., Levesque, J. & Bourgouin, P. (2001). Neural correlates of conscious self-regulation of emotion. The Journal of Neuroscience, 21, RC165.
9.
go back to reference Bloemers, J., Gerritsen, J., Bults, R., Koppeschaar, H., Everaerd, W., Olivier, B. et al. (2010). Induction of sexual arousal in women under conditions of institutional and ambulatory laboratory circumstances: a comparative study. Journal of Sexual Medicine, 7, 1160–1176. Bloemers, J., Gerritsen, J., Bults, R., Koppeschaar, H., Everaerd, W., Olivier, B. et al. (2010). Induction of sexual arousal in women under conditions of institutional and ambulatory laboratory circumstances: a comparative study. Journal of Sexual Medicine, 7, 1160–1176.
10.
go back to reference Bloemers, J., Rooij, K. van, Poels, S., Goldstein, I., Everaerd, W., Koppeschaar, H. et al. (2013). Toward personalized sexual medicine (part 1): integrating the ‘dual control model’ into differential drug treatments for Hypoactive Sexual Desire Disorder and female sexual arousal disorder. Journal of Sexual Medicine, 10, 791–809. Bloemers, J., Rooij, K. van, Poels, S., Goldstein, I., Everaerd, W., Koppeschaar, H. et al. (2013). Toward personalized sexual medicine (part 1): integrating the ‘dual control model’ into differential drug treatments for Hypoactive Sexual Desire Disorder and female sexual arousal disorder. Journal of Sexual Medicine, 10, 791–809.
11.
go back to reference Bos, P.A., Panksepp, J., Bluthe, R.M. & Honk, J.V. (2011). Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies. Frontiers in Neuroendocrinology. Bos, P.A., Panksepp, J., Bluthe, R.M. & Honk, J.V. (2011). Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies. Frontiers in Neuroendocrinology.
12.
go back to reference Brand, J.S., Schouw, Y.T. van der (2010). Testosterone, SHBG and cardiovascular health in postmenopausal women. International Journal of Impotence Research, 22, 91–104. Brand, J.S., Schouw, Y.T. van der (2010). Testosterone, SHBG and cardiovascular health in postmenopausal women. International Journal of Impotence Research, 22, 91–104.
13.
go back to reference Braunstein, G.D. (2007). Safety of testosterone treatment in postmenopausal women. Fertility and Sterility, 88, 1–17. Braunstein, G.D. (2007). Safety of testosterone treatment in postmenopausal women. Fertility and Sterility, 88, 1–17.
14.
go back to reference Braunstein, G.D., Sundwall, D.A., Katz, M., Shifren, J.L., Buster, J.E., Simon, J.A. et al. (2005). Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Archives of Internal Medicine, 165, 1582–1589. Braunstein, G.D., Sundwall, D.A., Katz, M., Shifren, J.L., Buster, J.E., Simon, J.A. et al. (2005). Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Archives of Internal Medicine, 165, 1582–1589.
15.
go back to reference Chamberlain, N.L., Driver, E.D. & Miesfeld, R.L. (1994). The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Research, 22, 3181–3186. Chamberlain, N.L., Driver, E.D. & Miesfeld, R.L. (1994). The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Research, 22, 3181–3186.
16.
go back to reference Childress, A.R., Ehrman, R.N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. et al. (2008). Prelude to passion: limbic activation by ‘unseen’ drug and sexual cues. PLoS One, 3, e1506. Childress, A.R., Ehrman, R.N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. et al. (2008). Prelude to passion: limbic activation by ‘unseen’ drug and sexual cues. PLoS One, 3, e1506.
17.
go back to reference Clayton, A.H. (2010). The pathophysiology of hypoactive sexual desire disorder in women. International Journal of Gynecology and Obstetrics, 110, 7–11. Clayton, A.H. (2010). The pathophysiology of hypoactive sexual desire disorder in women. International Journal of Gynecology and Obstetrics, 110, 7–11.
18.
go back to reference Corbin, J. & Francis, S. (1999). Cyclic GMP phosphodiesterase-5: Target of sildenafil. Journal of Biological Chemistry, 274, 13729–13732. Corbin, J. & Francis, S. (1999). Cyclic GMP phosphodiesterase-5: Target of sildenafil. Journal of Biological Chemistry, 274, 13729–13732.
19.
go back to reference Cottingham, S.L. & Pfaff, D. (1986). Interconnectedness of steroid-binding hormones: existence and implications. In: Gauten, D., editor. Current Topics in Endocrinology. Berlin: Springer, pp. 223–240. Cottingham, S.L. & Pfaff, D. (1986). Interconnectedness of steroid-binding hormones: existence and implications. In: Gauten, D., editor. Current Topics in Endocrinology. Berlin: Springer, pp. 223–240.
20.
go back to reference Dabbs, J.D.M., editor (2000). Heroes, rogues, and lovers: Testosterone and behavior. New York: McGraw-Hill. Dabbs, J.D.M., editor (2000). Heroes, rogues, and lovers: Testosterone and behavior. New York: McGraw-Hill.
21.
go back to reference Davis, S., Papalia, M.A., Norman, R.J., O’Neill, S., Redelman, M., Williamson, M. et al. (2008). Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial. Annals of Internal Medicine, 148, 569–577. Davis, S., Papalia, M.A., Norman, R.J., O’Neill, S., Redelman, M., Williamson, M. et al. (2008). Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial. Annals of Internal Medicine, 148, 569–577.
22.
go back to reference Davis, S.R, Moreau, M., Kroll, R., Bouchard, C., Panay, N., Gass, M. et al. (2008). Testosterone for low libido in postmenopausal women not taking estrogen. New England Journal of Medicine, 359, 2005–2017. Davis, S.R, Moreau, M., Kroll, R., Bouchard, C., Panay, N., Gass, M. et al. (2008). Testosterone for low libido in postmenopausal women not taking estrogen. New England Journal of Medicine, 359, 2005–2017.
23.
go back to reference Davis, S.R., Braunstein, G.D. (2012). Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women. Journal of Sexual Medicine, 9, 1134–1148. Davis, S.R., Braunstein, G.D. (2012). Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women. Journal of Sexual Medicine, 9, 1134–1148.
24.
go back to reference Davis, S.R., Hirschberg, A.L., Wagner, L.K., Lodhi, I., Schoultz, B. von (2009). The effect of transdermal testosterone on mammographic density in postmenopausal women not receiving systemic estrogen therapy. Journal of Clinical Endocrinology & Metabolism, 94, 4907–4913. Davis, S.R., Hirschberg, A.L., Wagner, L.K., Lodhi, I., Schoultz, B. von (2009). The effect of transdermal testosterone on mammographic density in postmenopausal women not receiving systemic estrogen therapy. Journal of Clinical Endocrinology & Metabolism, 94, 4907–4913.
25.
go back to reference Davis, S.R., Wolfe, R., Farrugia, H., Ferdinand, A. & Bell, R.J. (2009). The incidence of invasive breast cancer among women prescribed testosterone for low libido. Journal of Sexual Medicine, 6, 1850–1856. Davis, S.R., Wolfe, R., Farrugia, H., Ferdinand, A. & Bell, R.J. (2009). The incidence of invasive breast cancer among women prescribed testosterone for low libido. Journal of Sexual Medicine, 6, 1850–1856.
26.
go back to reference Davison, S.L. & Davis, S.R. (2011). Androgenic hormones and aging − the link with female sexual function. Hormones and Behavior, 59, 745–753. Davison, S.L. & Davis, S.R. (2011). Androgenic hormones and aging − the link with female sexual function. Hormones and Behavior, 59, 745–753.
27.
go back to reference Eisenegger, C., Haushofer, J. & Fehr, E. (2011). The role of testosterone in social interaction. Trends in Cognitive Sciences, 15, 263–271. Eisenegger, C., Haushofer, J. & Fehr, E. (2011). The role of testosterone in social interaction. Trends in Cognitive Sciences, 15, 263–271.
28.
go back to reference El-Hage, G., Eden, J.A. & Manga, R.Z. (2007). A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder. Climacteric, 10, 335–343. El-Hage, G., Eden, J.A. & Manga, R.Z. (2007). A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder. Climacteric, 10, 335–343.
29.
go back to reference Fogle, R.H., Stanczyk, F.Z., Zhang, X. & Paulson, R.J. (2007). Ovarian androgen production in postmenopausal women. Journal of Clinical Endocrinology & Metabolism, 92, 3040–3043. Fogle, R.H., Stanczyk, F.Z., Zhang, X. & Paulson, R.J. (2007). Ovarian androgen production in postmenopausal women. Journal of Clinical Endocrinology & Metabolism, 92, 3040–3043.
30.
go back to reference Hamilton, L.D. & Meston, C.M. (2010). The effects of partner togetherness on salivary testosterone in women in long distance relationships. Hormones and Behavior, 57, 198–202. Hamilton, L.D. & Meston, C.M. (2010). The effects of partner togetherness on salivary testosterone in women in long distance relationships. Hormones and Behavior, 57, 198–202.
31.
go back to reference Hayes, D.J. & Greenshaw, A.J. (2011). 5-HT receptors and reward-related behaviour: a review. Neuroscience and Biobehavioral Reviews, 35, 1419–1449. Hayes, D.J. & Greenshaw, A.J. (2011). 5-HT receptors and reward-related behaviour: a review. Neuroscience and Biobehavioral Reviews, 35, 1419–1449.
32.
go back to reference Hermans, E.J., Bos, P.A., Ossewaarde. L., Ramsey, N.F., Fernandez, G. & Honk J. van (2010). Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy women. Neuroimage, 52, 277–283. Hermans, E.J., Bos, P.A., Ossewaarde. L., Ramsey, N.F., Fernandez, G. & Honk J. van (2010). Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy women. Neuroimage, 52, 277–283.
33.
go back to reference Hermans, E.J., Putman, P. & Honk, J. van (2006). Testosterone administration reduces empathetic behavior: a facial mimicry study. Psychoneuroendocrinology, 31, 859–866. Hermans, E.J., Putman, P. & Honk, J. van (2006). Testosterone administration reduces empathetic behavior: a facial mimicry study. Psychoneuroendocrinology, 31, 859–866.
34.
go back to reference Hermans, E.J., Putman, P., Baas, J.M, Gecks, N.M., Kenemans, J.L. & Honk J. van (2007). Exogenous testosterone attenuates the integrated central stress response in healthy young women. Psychoneuroendocrinology, 32, 1052–1061. Hermans, E.J., Putman, P., Baas, J.M, Gecks, N.M., Kenemans, J.L. & Honk J. van (2007). Exogenous testosterone attenuates the integrated central stress response in healthy young women. Psychoneuroendocrinology, 32, 1052–1061.
35.
go back to reference Hermans, E.J., Ramsey, N.F. & Honk, J. van (2008). Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biological Psychiatry, 63, 263–270. Hermans, E.J., Ramsey, N.F. & Honk, J. van (2008). Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biological Psychiatry, 63, 263–270.
36.
go back to reference Hobbs, A. & Ignarro, L. (1996). Nitric oxide cyclic GMP signal transduction system. Nitric Oxide, Pt B, 269, 134–148. Hobbs, A. & Ignarro, L. (1996). Nitric oxide cyclic GMP signal transduction system. Nitric Oxide, Pt B, 269, 134–148.
37.
go back to reference Hofling, M., Hirschberg, A.L, Skoog, L., Tani, E., Hagerstrom, T., Schoultz, B. von (2007). Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women. Menopause, 14, 183–190. Hofling, M., Hirschberg, A.L, Skoog, L., Tani, E., Hagerstrom, T., Schoultz, B. von (2007). Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women. Menopause, 14, 183–190.
38.
go back to reference Honk, J. van, Peper, J.S. & Schutter, D.J. (2005). Testosterone reduces unconscious fear but not consciously experienced anxiety: implications for the disorders of fear and anxiety. Biological Psychiatry, 58, 218–225. Honk, J. van, Peper, J.S. & Schutter, D.J. (2005). Testosterone reduces unconscious fear but not consciously experienced anxiety: implications for the disorders of fear and anxiety. Biological Psychiatry, 58, 218–225.
39.
go back to reference Honk, J. van, Schutter, D.J, Hermans, E.J, Putman, P., Tuiten, A. & Koppeschaar, H. (2004). Testosterone shifts the balance between sensitivity for punishment and reward in healthy young women. Psychoneuroendocrinology, 29, 937–943. Honk, J. van, Schutter, D.J, Hermans, E.J, Putman, P., Tuiten, A. & Koppeschaar, H. (2004). Testosterone shifts the balance between sensitivity for punishment and reward in healthy young women. Psychoneuroendocrinology, 29, 937–943.
40.
go back to reference Honk, J. van, Schutter, D.J. (2007). Testosterone reduces conscious detection of signals serving social correction: implications for antisocial behavior. Psychological Science, 18, 663–667. Honk, J. van, Schutter, D.J. (2007). Testosterone reduces conscious detection of signals serving social correction: implications for antisocial behavior. Psychological Science, 18, 663–667.
41.
go back to reference Hull, E.M. & Dominguez, J.M. (2007). Sexual behavior in male rodents. Hormones and Behavior, 52, 45–55. Hull, E.M. & Dominguez, J.M. (2007). Sexual behavior in male rodents. Hormones and Behavior, 52, 45–55.
42.
go back to reference Joseph, R. (1999). Environmental influences on neural plasticity, the limbic system, emotional development and attachment: a review. Child Psychiatry and Human Development, 29, 189–208. Joseph, R. (1999). Environmental influences on neural plasticity, the limbic system, emotional development and attachment: a review. Child Psychiatry and Human Development, 29, 189–208.
43.
go back to reference Kaaks, R., Rinaldi, S., Key, T.J., Berrino, F., Peeters, P.H., Biessy, C. et al. (2005). Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocrine-Related Cancer, 12, 1071–1082. Kaaks, R., Rinaldi, S., Key, T.J., Berrino, F., Peeters, P.H., Biessy, C. et al. (2005). Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocrine-Related Cancer, 12, 1071–1082.
44.
go back to reference Karama, S., Lecours, A.R., Leroux, J.M., Bourgouin, P., Beaudoin, G, Joubert, S. et al. (2002). Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping, 16, 1–13. Karama, S., Lecours, A.R., Leroux, J.M., Bourgouin, P., Beaudoin, G, Joubert, S. et al. (2002). Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping, 16, 1–13.
45.
go back to reference Kenemans, P. & Mooren, M.J. van der (2012). Androgens and breast cancer risk. Gynecological Endocrinology, 28 Suppl 1, 46–49. Kenemans, P. & Mooren, M.J. van der (2012). Androgens and breast cancer risk. Gynecological Endocrinology, 28 Suppl 1, 46–49.
46.
go back to reference Laumann, E.O., Paik, A. & Rosen, R.C. (1999). Sexual dysfunction in the United States: prevalence and predictors. JAMA, 281, 537–544. Laumann, E.O., Paik, A. & Rosen, R.C. (1999). Sexual dysfunction in the United States: prevalence and predictors. JAMA, 281, 537–544.
47.
go back to reference Lobo, R.A., Rosen, R.C., Yang, H.M., Block, B., Hoop, R.G. van der (2003). Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertility and Sterility, 79, 1341–1352. Lobo, R.A., Rosen, R.C., Yang, H.M., Block, B., Hoop, R.G. van der (2003). Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertility and Sterility, 79, 1341–1352.
48.
go back to reference Made, F. van der, Bloemers, J., Ham, D. van, El Yassem, W., Kleiverda, G., Everaerd, W. et al. (2009a). Childhood sexual abuse, selective attention for sexual cues and the effects of testosterone with or without vardenafil on physiological sexual arousal in women with sexual dysfunction: a pilot study. Journal of Sexual Medicine, 6, 429–439. Made, F. van der, Bloemers, J., Ham, D. van, El Yassem, W., Kleiverda, G., Everaerd, W. et al. (2009a). Childhood sexual abuse, selective attention for sexual cues and the effects of testosterone with or without vardenafil on physiological sexual arousal in women with sexual dysfunction: a pilot study. Journal of Sexual Medicine, 6, 429–439.
49.
go back to reference Made, F. van der, Bloemers, J., Yassem, W.E., Kleiverda, G., Everaerd, W., Ham, D. van et al. (2009b). The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction. Journal of Sexual Medicine, 6, 777–790. Made, F. van der, Bloemers, J., Yassem, W.E., Kleiverda, G., Everaerd, W., Ham, D. van et al. (2009b). The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction. Journal of Sexual Medicine, 6, 777–790.
50.
go back to reference Mendel, C. (1989). The Free Hormone Hypothesis – a Physiologically Based Mathematical-Model. Endocrine Reviews, 10, 232–274. Mendel, C. (1989). The Free Hormone Hypothesis – a Physiologically Based Mathematical-Model. Endocrine Reviews, 10, 232–274.
51.
go back to reference Mifsud, A., Ramirez, S. & Yong, E. (2000). Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. Journal of Clinical Endocrinology & Metabolism, 85, 3484–3488. Mifsud, A., Ramirez, S. & Yong, E. (2000). Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. Journal of Clinical Endocrinology & Metabolism, 85, 3484–3488.
52.
go back to reference Miller, S.L. & Maner, J.K. (2010). Scent of a woman: men’s testosterone responses to olfactory ovulation cues. Psychological Science, 21, 276–283. Miller, S.L. & Maner, J.K. (2010). Scent of a woman: men’s testosterone responses to olfactory ovulation cues. Psychological Science, 21, 276–283.
53.
go back to reference Nachtigall, L., Casson, P., Lucas, J., Schofield, V., Melson, C. & Simon, J.A. (2011). Safety and tolerability of testosterone patch therapy for up to 4 years in surgically menopausal women receiving oral or transdermal oestrogen. Gynecological Endocrinology, 27, 39–48. Nachtigall, L., Casson, P., Lucas, J., Schofield, V., Melson, C. & Simon, J.A. (2011). Safety and tolerability of testosterone patch therapy for up to 4 years in surgically menopausal women receiving oral or transdermal oestrogen. Gynecological Endocrinology, 27, 39–48.
54.
go back to reference Nathorst-Boos, J., Floter, A., Jarkander-Rolff, M., Carlstrom, K. & Schoultz, B. (2006). Treatment with percutaneous testosterone gel in postmenopausal women with decreased libido-effects on sexuality and psychological general well-being. Maturitas, 53, 11–18. Nathorst-Boos, J., Floter, A., Jarkander-Rolff, M., Carlstrom, K. & Schoultz, B. (2006). Treatment with percutaneous testosterone gel in postmenopausal women with decreased libido-effects on sexuality and psychological general well-being. Maturitas, 53, 11–18.
55.
go back to reference Okazawa, H., Yamane, F., Blierm P, & Diksic, M. (1999). Effects of acute and chronic administration of the serotonina(1A) agonist buspirone on serotonin synthesis in the rat brain. Journal of Neurochemistry, 72, 2022–2031. Okazawa, H., Yamane, F., Blierm P, & Diksic, M. (1999). Effects of acute and chronic administration of the serotonina(1A) agonist buspirone on serotonin synthesis in the rat brain. Journal of Neurochemistry, 72, 2022–2031.
56.
go back to reference Pineyro, G. & Blier, P. (1999). Autoregulation of serotonin neurons: Role in antidepressant drug action. Pharmacological Reviews, 51, 533–591. Pineyro, G. & Blier, P. (1999). Autoregulation of serotonin neurons: Role in antidepressant drug action. Pharmacological Reviews, 51, 533–591.
57.
go back to reference Poels, S., Bloemers, J., Rooij, K. van, Goldstein, I., Gerritsen, J., Ham, D. van et al. (2013). Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. Journal of Sexual Medicine, 10, 810–823. Poels, S., Bloemers, J., Rooij, K. van, Goldstein, I., Gerritsen, J., Ham, D. van et al. (2013). Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. Journal of Sexual Medicine, 10, 810–823.
58.
go back to reference Postma, A., Meyer, G., Tuiten, A., Honk, J. van, Kessels, R.P. & Thijssen, J. (2000). Effects of testosterone administration on selective aspects of object-location memory in healthy young women. Psychoneuroendocrinology, 25, 563–575. Postma, A., Meyer, G., Tuiten, A., Honk, J. van, Kessels, R.P. & Thijssen, J. (2000). Effects of testosterone administration on selective aspects of object-location memory in healthy young women. Psychoneuroendocrinology, 25, 563–575.
59.
go back to reference Roney, J.R., Lukaszewski, A.W. & Simmons, Z.L. (2007). Rapid endocrine responses of young men to social interactions with young women. Hormones and Behavior, 52, 326–333. Roney, J.R., Lukaszewski, A.W. & Simmons, Z.L. (2007). Rapid endocrine responses of young men to social interactions with young women. Hormones and Behavior, 52, 326–333.
60.
go back to reference Rooij, K. van, Bloemers, J., Leede, L. de, Goldstein, I., Lentjes, E., Koppeschaar, H. et al. (2012). Pharmacokinetics of three doses of sublingual testosterone in healthy premenopausal women. Psychoneuroendocrinology, 37, 773–781. Rooij, K. van, Bloemers, J., Leede, L. de, Goldstein, I., Lentjes, E., Koppeschaar, H. et al. (2012). Pharmacokinetics of three doses of sublingual testosterone in healthy premenopausal women. Psychoneuroendocrinology, 37, 773–781.
61.
go back to reference Rooij, K. van, Poels, S., Bloemers, J., Goldstein, I., Gerritsen, J., Ham, D. van et al. (2013). Toward personalized sexual medicine (part 3): testosterone combined with a Serotonin1A receptor agonist increases sexual satisfaction in women with HSDD and FSAD, and dysfunctional activation of sexual inhibitory mechanisms. Journal of Sexual Medicine, 10, 824–837. Rooij, K. van, Poels, S., Bloemers, J., Goldstein, I., Gerritsen, J., Ham, D. van et al. (2013). Toward personalized sexual medicine (part 3): testosterone combined with a Serotonin1A receptor agonist increases sexual satisfaction in women with HSDD and FSAD, and dysfunctional activation of sexual inhibitory mechanisms. Journal of Sexual Medicine, 10, 824–837.
62.
go back to reference Schutter, D.J. & Honk, J. van (2004). Decoupling of midfrontal delta-beta oscillations after testosterone administration. International Journal of Psychophysiology, 53, 71–73. Schutter, D.J. & Honk, J. van (2004). Decoupling of midfrontal delta-beta oscillations after testosterone administration. International Journal of Psychophysiology, 53, 71–73.
63.
go back to reference Secreto, G., Venturelli, E., Meneghini, E., Carcangium M.L., Paolini, B., Agresti, R. et al. (2012). Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers. BMC Cancer, 12, 599,2407-12-599. Secreto, G., Venturelli, E., Meneghini, E., Carcangium M.L., Paolini, B., Agresti, R. et al. (2012). Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers. BMC Cancer, 12, 599,2407-12-599.
64.
go back to reference Sherwin, B.B., Gelfand, M.M. & Brender, W. (1985). Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosomatic Medicine, 47, 339–351. Sherwin, B.B., Gelfand, M.M. & Brender, W. (1985). Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosomatic Medicine, 47, 339–351.
65.
go back to reference Shifren, J..L, Braunstein, G.D., Simon, J.A., Casson, P.R., Buster, J.E., Redmond, G.P. et al. (2000). Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. New England Journal of Medicine, 343, 682–688. Shifren, J..L, Braunstein, G.D., Simon, J.A., Casson, P.R., Buster, J.E., Redmond, G.P. et al. (2000). Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. New England Journal of Medicine, 343, 682–688.
66.
go back to reference Shifren, J.L., Monz, B.U., Russo, P.A., Segreti, A. & Johannes, C.B. (2008). Sexual problems and distress in United States women: prevalence and correlates. Obstetrics & Gynecology, 112, 970–978. Shifren, J.L., Monz, B.U., Russo, P.A., Segreti, A. & Johannes, C.B. (2008). Sexual problems and distress in United States women: prevalence and correlates. Obstetrics & Gynecology, 112, 970–978.
67.
go back to reference Simon, J., Braunstein, G., Nachtigall, L., Utian, W., Katz, M., Miller, S. et al. (2005). Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. The Journal of Clinical Endocrinology & Metabolism, 90, 5226–5233. Simon, J., Braunstein, G., Nachtigall, L., Utian, W., Katz, M., Miller, S. et al. (2005). Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. The Journal of Clinical Endocrinology & Metabolism, 90, 5226–5233.
68.
go back to reference Slatcher, R.B., Mehta, P.H. & Josephs, R.A. (2011). Testosterone and self-reported dominance interact to influence human mating behavior. Social Psychological and Personality Science, 2, 531–539. Slatcher, R.B., Mehta, P.H. & Josephs, R.A. (2011). Testosterone and self-reported dominance interact to influence human mating behavior. Social Psychological and Personality Science, 2, 531–539.
69.
go back to reference Snabes, M.C., Berry, S., Zborowski, J. & White, W. (2012). Libigel (R) (Testosterone Gel) Safety Study Completes Enrollment and Continues with a Low Cv Event Rate. Journal of Sexual Medicine, 9, 166-. Snabes, M.C., Berry, S., Zborowski, J. & White, W. (2012). Libigel (R) (Testosterone Gel) Safety Study Completes Enrollment and Continues with a Low Cv Event Rate. Journal of Sexual Medicine, 9, 166-.
70.
go back to reference Snabes, M.C., Zborowski, J. & Simes, S. (2012). Libigel (R) (Testosterone Gel) does Not Differentiate from Placebo Therapy in the Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women. Journal of Sexual Medicine, 9, 171-. Snabes, M.C., Zborowski, J. & Simes, S. (2012). Libigel (R) (Testosterone Gel) does Not Differentiate from Placebo Therapy in the Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women. Journal of Sexual Medicine, 9, 171-.
71.
go back to reference Staa, T.P. van & Sprafka, J.M. (2009). Study of adverse outcomes in women using testosterone therapy. Maturitas, 62, 76–80. Staa, T.P. van & Sprafka, J.M. (2009). Study of adverse outcomes in women using testosterone therapy. Maturitas, 62, 76–80.
72.
go back to reference Stoleru, S., Gregoire, M.C., Gerard, D., Decety, J., Lafarge, E., Cinotti, L. et al. (1999). Neuroanatomical correlates of visually evoked sexual arousal in human males. Archives of Sexual Behavior, 28, 1–21. Stoleru, S., Gregoire, M.C., Gerard, D., Decety, J., Lafarge, E., Cinotti, L. et al. (1999). Neuroanatomical correlates of visually evoked sexual arousal in human males. Archives of Sexual Behavior, 28, 1–21.
73.
go back to reference Tops, M., Russo, S., Boksem, M.A. & Tucker, D.M. (2009). Serotonin: modulator of a drive to withdraw. Brain and Cognition, 71, 427–436. Tops, M., Russo, S., Boksem, M.A. & Tucker, D.M. (2009). Serotonin: modulator of a drive to withdraw. Brain and Cognition, 71, 427–436.
74.
go back to reference Tuiten, A., Honk, J. van, Koppeschaar, H., Bernaards, C., Thijssen, J. & Verbaten, R. (2000). Time course of effects of testosterone administration on sexual arousal in women. Archives of General Psychiatry, 57, 149–153; discussion 155–156. Tuiten, A., Honk, J. van, Koppeschaar, H., Bernaards, C., Thijssen, J. & Verbaten, R. (2000). Time course of effects of testosterone administration on sexual arousal in women. Archives of General Psychiatry, 57, 149–153; discussion 155–156.
75.
go back to reference Tuiten, A., Honk, J. van, Verbaten, R., Laan, E., Everaerd, W. & Stam, H. (2002). Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Archives of General Psychiatry, 59, 465–466. Tuiten, A., Honk, J. van, Verbaten, R., Laan, E., Everaerd, W. & Stam, H. (2002). Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Archives of General Psychiatry, 59, 465466.
76.
go back to reference Tuiten, A., Laan, E., Panhuysen, G., Everaerd, W., Haan, E. de, Koppeschaar, H. et al. (1996). Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosomatic Medicine, 58, 234–241. Tuiten, A., Laan, E., Panhuysen, G., Everaerd, W., Haan, E. de, Koppeschaar, H. et al. (1996). Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosomatic Medicine, 58, 234–241.
77.
go back to reference Woolcott, C.G., Shvetsov, Y.B., Stanczyk, F.Z., Wilkens, L.R., White, K.K, Caberto, C. et al. (2010). Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: the Multiethnic Cohort Study. Endocrine-Related Cancer, 17, 125–134. Woolcott, C.G., Shvetsov, Y.B., Stanczyk, F.Z., Wilkens, L.R., White, K.K, Caberto, C. et al. (2010). Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: the Multiethnic Cohort Study. Endocrine-Related Cancer, 17, 125–134.
78.
go back to reference Zhang, X., Tworoger, S.S., Eliassen, A.H. & Hankinson, S.E. (2013). Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up. Breast Cancer Research and Treatment, 137, 883–892. Zhang, X., Tworoger, S.S., Eliassen, A.H. & Hankinson, S.E. (2013). Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up. Breast Cancer Research and Treatment, 137, 883–892.
Metagegevens
Titel
Een vernieuwende farmacotherapeutische behandeling voor vrouwen met hypoactive sexual desire disorder
Auteurs
Saskia Poels
Jos Bloemers
Kim van Rooij
Hans Koppeschaar
Berend Olivier
Adriaan Tuiten
Publicatiedatum
01-02-2014
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 1/2014
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-014-0038-z