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13-11-2023

Quality of life in postmenopausal women with osteoporosis and osteopenia: associations with bone microarchitecture and nutritional status

Auteurs: Marin Mornar, Anela Novak, Josko Bozic, Josip Vrdoljak, Marko Kumric, Tina Vilovic, Ivan Rakovic, Tina Ticinovic Kurir, Dinko Martinovic, Hrvoje Urlic, Marino Vilovic

Gepubliceerd in: Quality of Life Research | Uitgave 2/2024

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Abstract

Purpose

Primary aim of the study was to investigate the status of different health-related quality of life (HRQoL) domains in postmenopausal women with osteoporosis and osteopenia, and to explore possible associations with bone microarchitecture and nutritional status.

Methods

This was a single-center cross-sectional study that included 232 postmenopausal women, from which they were divided into three groups—osteoporosis (OP, N = 63), osteopenia (OPIA, N = 123), and control group (N = 46). Detailed medical history data and anthropometric measurements were taken from all women. Bone structure parameters were taken with DXA device, with additional analysis of bone microarchitecture status with Trabecular Bone Score (TBS). Nutritional status was assessed with Mini Nutritional Assessment (MNA) questionnaire, and HRQoL with Medical Outcomes Study Short Form-36 (SF-36) questionnaire.

Results

Nutrition evaluation analysis have shown that patients in OP group had significantly lower values of MNA score compared to the OPIA group and control group (P = 0.005). Furthermore, a significant positive correlation was found between all of the SF-36 domains and MNA scores, while significant positive correlation was found between TBS values and Physical functioning (P < 0.001), Bodily pain (P = 0.027), Social functioning (P = 0.029), and Vitality domains (P = 0.041) in total investigated population. Further analyses were performed only in OP and OPIA groups, and TBS score showed significant positive correlation with Physical functioning (r = 0.248, P < 0.001) and Bodily pain domains as well (r = 0.180, P = 0.014), while MNA score positively correlated with each of the SF-36 domains. Multiple regression models have shown that MNA score retained significant association with each SF-36 domains, and TBS value with Physical functioning (P = 0.003), Social functioning (P = 0.012), and Vitality domains (P = 0.014).

Conclusion

This study highlights the associations that TBS has with some domains of HRQoL in postmenopausal women with osteoporosis and osteopenia. Moreover, nutritional status could play a role in the complex interplay between TBS and HRQoL.
Literatuur
7.
go back to reference Varacallo, M., Seaman, T. J., Jandu, J. S., & Pizzutillo, P. (2022). Osteopenia. StatPearls Publishing. Varacallo, M., Seaman, T. J., Jandu, J. S., & Pizzutillo, P. (2022). Osteopenia. StatPearls Publishing.
12.
go back to reference Allo Miguel, G., Serraclara Plá, A., Partida Muñoz, M. L., Martínez Díaz-Guerra, G., & Hawkins, F. (2016). Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center. Therapeutic Advances in Endocrinology and Metabolism, 7(3), 93–100. https://doi.org/10.1177/2042018816643908CrossRefPubMedPubMedCentral Allo Miguel, G., Serraclara Plá, A., Partida Muñoz, M. L., Martínez Díaz-Guerra, G., & Hawkins, F. (2016). Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center. Therapeutic Advances in Endocrinology and Metabolism, 7(3), 93–100. https://​doi.​org/​10.​1177/​2042018816643908​CrossRefPubMedPubMedCentral
27.
go back to reference Hans, D., Barthe, N., Boutroy, S., Pothuaud, L., Winzenrieth, R., & Krieg, M. A. (2011). Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: An experimental study on human cadaver vertebrae. Journal of Clinical Densitometry, 14(3), 302–312. https://doi.org/10.1016/j.jocd.2011.05.005CrossRefPubMed Hans, D., Barthe, N., Boutroy, S., Pothuaud, L., Winzenrieth, R., & Krieg, M. A. (2011). Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: An experimental study on human cadaver vertebrae. Journal of Clinical Densitometry, 14(3), 302–312. https://​doi.​org/​10.​1016/​j.​jocd.​2011.​05.​005CrossRefPubMed
29.
go back to reference Silva, B. C., Leslie, W. D., Resch, H., Lamy, O., Lesnyak, O., Binkley, N., McCloskey, E. V., Kanis, J. A., & Bilezikian, J. P. (2014). Trabecular bone score: A noninvasive analytical method based upon the DXA image. Journal of Bone and Mineral Research, 29(3), 518–530. https://doi.org/10.1002/jbmr.2176CrossRefPubMed Silva, B. C., Leslie, W. D., Resch, H., Lamy, O., Lesnyak, O., Binkley, N., McCloskey, E. V., Kanis, J. A., & Bilezikian, J. P. (2014). Trabecular bone score: A noninvasive analytical method based upon the DXA image. Journal of Bone and Mineral Research, 29(3), 518–530. https://​doi.​org/​10.​1002/​jbmr.​2176CrossRefPubMed
32.
go back to reference Kanis, J. A., Oden, A., Johnell, O., Johansson, H., De Laet, C., Brown, J., Burckhardt, P., Cooper, C., Christiansen, C., Cummings, S., Eisman, J. A., Fujiwara, S., Glüer, C., Goltzman, D., Hans, D., Krieg, M. A., La Croix, A., McCloskey, E., Mellstrom, D., … Yoshimura, N. (2007). The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International, 18(8), 1033–1046. https://doi.org/10.1007/s00198-007-0343-yCrossRefPubMed Kanis, J. A., Oden, A., Johnell, O., Johansson, H., De Laet, C., Brown, J., Burckhardt, P., Cooper, C., Christiansen, C., Cummings, S., Eisman, J. A., Fujiwara, S., Glüer, C., Goltzman, D., Hans, D., Krieg, M. A., La Croix, A., McCloskey, E., Mellstrom, D., … Yoshimura, N. (2007). The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International, 18(8), 1033–1046. https://​doi.​org/​10.​1007/​s00198-007-0343-yCrossRefPubMed
34.
go back to reference McCloskey, E. V., Odén, A., Harvey, N. C., Leslie, W. D., Hans, D., Johansson, H., Barkmann, R., Boutroy, S., Brown, J., Chapurlat, R., Elders, P. J. M., Fujita, Y., Glüer, C. C., Goltzman, D., Iki, M., Karlsson, M., Kindmark, A., Kotowicz, M., Kurumatani, N., … Kanis, J. A. (2016). A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research, 31(5), 940–948. https://doi.org/10.1002/jbmr.2734CrossRefPubMed McCloskey, E. V., Odén, A., Harvey, N. C., Leslie, W. D., Hans, D., Johansson, H., Barkmann, R., Boutroy, S., Brown, J., Chapurlat, R., Elders, P. J. M., Fujita, Y., Glüer, C. C., Goltzman, D., Iki, M., Karlsson, M., Kindmark, A., Kotowicz, M., Kurumatani, N., … Kanis, J. A. (2016). A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research, 31(5), 940–948. https://​doi.​org/​10.​1002/​jbmr.​2734CrossRefPubMed
37.
go back to reference Maslić Sersić, D., & Vuletić, G. (2006). Psychometric evaluation and establishing norms of Croatian SF-36 health survey: Framework for subjective health research. Croatian Medical Journal, 47(1), 95–102.PubMedPubMedCentral Maslić Sersić, D., & Vuletić, G. (2006). Psychometric evaluation and establishing norms of Croatian SF-36 health survey: Framework for subjective health research. Croatian Medical Journal, 47(1), 95–102.PubMedPubMedCentral
38.
go back to reference Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical care, 30(6), 473–483.CrossRefPubMed Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical care, 30(6), 473–483.CrossRefPubMed
40.
go back to reference Kaiser, M. J., Bauer, J. M., Ramsch, C., Uter, W., Guigoz, Y., Cederholm, T., Thomas, D. R., Anthony, P., Charlton, K. E., Maggio, M., Tsai, A. C., Grathwohl, D., Vellas, B., & Sieber, C. C. (2009). Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. The Journal of Nutrition, Health & Aging, 13(9), 782–788. https://doi.org/10.1007/s12603-009-0214-7CrossRef Kaiser, M. J., Bauer, J. M., Ramsch, C., Uter, W., Guigoz, Y., Cederholm, T., Thomas, D. R., Anthony, P., Charlton, K. E., Maggio, M., Tsai, A. C., Grathwohl, D., Vellas, B., & Sieber, C. C. (2009). Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. The Journal of Nutrition, Health & Aging, 13(9), 782–788. https://​doi.​org/​10.​1007/​s12603-009-0214-7CrossRef
43.
go back to reference Romagnoli, E., Carnevale, V., Nofroni, I., D’Erasmo, E., Paglia, F., De Geronimo, S., Pepe, J., Raejntroph, N., Maranghi, M., & Minisola, S. (2004). Quality of life in ambulatory postmenopausal women: The impact of reduced bone mineral density and subclinical vertebral fractures. Osteoporosis International, 15(12), 975–980. https://doi.org/10.1007/s00198-004-1633-2CrossRefPubMed Romagnoli, E., Carnevale, V., Nofroni, I., D’Erasmo, E., Paglia, F., De Geronimo, S., Pepe, J., Raejntroph, N., Maranghi, M., & Minisola, S. (2004). Quality of life in ambulatory postmenopausal women: The impact of reduced bone mineral density and subclinical vertebral fractures. Osteoporosis International, 15(12), 975–980. https://​doi.​org/​10.​1007/​s00198-004-1633-2CrossRefPubMed
46.
47.
go back to reference Ozeraitiene, V., & Būtenaite, V. (2006). The evaluation of bone mineral density based on nutritional status, age, and anthropometric parameters in elderly women. Medicina (Kaunas, Lithuania), 42(10), 836–842.PubMed Ozeraitiene, V., & Būtenaite, V. (2006). The evaluation of bone mineral density based on nutritional status, age, and anthropometric parameters in elderly women. Medicina (Kaunas, Lithuania), 42(10), 836–842.PubMed
50.
go back to reference Weaver, A. A., Houston, D. K., Shapses, S. A., Lyles, M. F., Henderson, R. M., Beavers, D. P., Baker, A. C., & Beavers, K. M. (2019). Effect of a hypocaloric, nutritionally complete, higher-protein meal plan on bone density and quality in older adults with obesity: A randomized trial. The American Journal of Clinical Nutrition, 109(2), 478–486. https://doi.org/10.1093/ajcn/nqy237CrossRefPubMedPubMedCentral Weaver, A. A., Houston, D. K., Shapses, S. A., Lyles, M. F., Henderson, R. M., Beavers, D. P., Baker, A. C., & Beavers, K. M. (2019). Effect of a hypocaloric, nutritionally complete, higher-protein meal plan on bone density and quality in older adults with obesity: A randomized trial. The American Journal of Clinical Nutrition, 109(2), 478–486. https://​doi.​org/​10.​1093/​ajcn/​nqy237CrossRefPubMedPubMedCentral
Metagegevens
Titel
Quality of life in postmenopausal women with osteoporosis and osteopenia: associations with bone microarchitecture and nutritional status
Auteurs
Marin Mornar
Anela Novak
Josko Bozic
Josip Vrdoljak
Marko Kumric
Tina Vilovic
Ivan Rakovic
Tina Ticinovic Kurir
Dinko Martinovic
Hrvoje Urlic
Marino Vilovic
Publicatiedatum
13-11-2023
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2024
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-023-03542-7