Skip to main content
Mijn bibliotheek
Shop
Nieuws Boeken Tijdschriften Toetsvragen Web-tv Video Audio
Tips voor Mijn BSL
Inloggen
Top
Quality of Life Research
Gepubliceerd in:

15-11-2023

Perceived health- related quality of life in persons with multiple sclerosis with and without a vascular comorbidity

Auteurs: Lindsay O. Neto, Jennifer A. Ruiz, Elizabeth S. Gromisch

Gepubliceerd in: Quality of Life Research | Uitgave 2/2024

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail
    Link delen
publish
Publiceer nu

Abstract

Purpose

Vascular comorbidities are prevalent and can contribute to adverse health outcomes in persons with multiple sclerosis (PwMS). Understanding the association between vascular comorbidities and health-related quality of life (HRQOL) among PwMS may be beneficial in improving outcomes and disease management. This cross-sectional study aimed to examine the relationship between vascular comorbidities and the different dimensions of HRQOL in PwMS.

Methods

Participants (n = 185) were PwMS recruited from a community-based comprehensive MS care center. Demographics, comorbid conditions, and disability level were collected via a self-report REDCap survey, with the 29-item Multiple Sclerosis Quality of Life (MSQOL-29) as the outcome measure. Regression models were used to examine the association between vascular comorbidities and the MSQOL-29, controlling for age, gender, ethnicity, level of education, marital status, MS subtype, disease duration, and disability.

Results

Approximately 35% reported at least one vascular comorbidity, with the most common being hypertension (27.0%), followed by hyperlipidemia (24.9%) and diabetes (8.1%). After factoring in for demographics and disability, having a vascular comorbidity was associated with lower physical HRQOL (β = – 10.05, 95% CI: – 28.24, 23.50), but not mental HRQOL (β = – 2.61, 95% CI: – 10.54, 5.32). Hypertension was negatively associated with several dimensions of HRQOL, including Physical Function, Change in Health, Health Perceptions, Energy, and Health Distress.

Conclusions

 Having at least one vascular comorbidity is associated with lower physical HRQOL, independent of demographics and level of physical disability. Focus should be directed to the physical burden and challenges vascular comorbidities may cause on the lives of PwMS.
vorige artikel Quality of life in postmenopausal women with osteoporosis and osteopenia: associations with bone microarchitecture and nutritional status
Literatuur
1.
CDC, Measuring healthy days: Population assessment of health-related quality of life. , in Centers for Disease Control and Prevention. 2000: Atlanta, Georgia.
2.
Hennessy, C. H., et al. (1994). Measuring health-related quality of life for public health surveillance. Public Health Reports, 109(5), 665–672.PubMedPubMedCentral
3.
4.
Marengoni, A., et al. (2011). Aging with multimorbidity: A systematic review of the literature. Ageing Research Reviews, 10(4), 430–439.PubMedCrossRef
5.
Makovski, T. T., et al. (2019). Multimorbidity and quality of life: Systematic literature review and meta-analysis. Ageing Research Reviews, 53, 100903.PubMedCrossRef
6.
The Multiple Sclerosis International Federation, Part 1: Mapping Multiple Sclerosis Around the World, Key Epidemiology Findings. 2020.
7.
Cattaneo, D., et al. (2017). Participation Restriction in People With Multiple Sclerosis: Prevalence and Correlations With Cognitive, Walking, Balance, and Upper Limb Impairments. Archives of Physical Medicine and Rehabilitation, 98(7), 1308–1315.PubMedCrossRef
8.
Fong, M. W., et al. (2015). Home functioning profiles in people with multiple sclerosis and their relation to disease characteristics and psychosocial functioning. Work, 52(4), 767–776.PubMedCrossRef
9.
Kalmar, J. H., et al. (2008). The relationship between cognitive deficits and everyday functional activities in multiple sclerosis. Neuropsychology, 22(4), 442–449.PubMedCrossRef
10.
Aymerich, M., I. Guillamon, and A.J. Jovell, Health-related quality of life assessment in people with multiple sclerosis and their family caregivers. A multicenter study in Catalonia (Southern Europe). Patient Prefer Adherence, 2009. 3: p. 311–21.
11.
Brola, W., et al. (2016). Self-reported quality of life in multiple sclerosis patients: Preliminary results based on the Polish MS Registry. Patient Preference and Adherence, 10, 1647–1656.PubMedPubMedCentralCrossRef
12.
13.
Alhazzani, A. A., et al. (2018). Quality of life assessment among multiple sclerosis patients in Saudi Arabia. Neurosciences (Riyadh), 23(2), 140–147.PubMedCrossRef
14.
Amtmann, D., et al. (2018). People with multiple sclerosis report significantly worse symptoms and health related quality of life than the US general population as measured by PROMIS and NeuroQoL outcome measures. Disability and Health Journal, 11(1), 99–107.PubMedCrossRef
15.
Ahmad, H., et al. (2020). Measuring the health-related quality of life in Australians with multiple sclerosis using the assessment of quality of life-8-dimension (AQoL-8D) multi-attribute utility instrument. Mult Scler Relat Disord, 44, 102358.PubMedCrossRef
16.
Ponzio, M., et al. (2020). Unmet needs influence health-related quality of life in people with multiple sclerosis. Mult Scler Relat Disord, 38, 101877.PubMedCrossRef
17.
Duka Glavor, K., M. Titlić, and G. Vuletic, Quality of life and health of patients in early stages of Multiple sclerosis. Psychiatr Danub, 2019. 31(Suppl 1): p. 118–125.
18.
Gavelova, M., et al. (2015). Importance of an individual’s evaluation of functional status for health-related quality of life in patients with multiple sclerosis. Disability and Health Journal, 8(3), 372–379.PubMedCrossRef
19.
Højsgaard Chow, H., et al. (2018). Progressive multiple sclerosis, cognitive function, and quality of life. Brain and Behavior: A Cognitive Neuroscience Perspective, 8(2), e00875.CrossRef
20.
Berrigan, L. I., et al. (2016). Health-related quality of life in multiple sclerosis: Direct and indirect effects of comorbidity. Neurology, 86(15), 1417–1424.PubMedPubMedCentralCrossRef
21.
Buchanan, R. J., et al. (2008). Rural-urban analyses of health-related quality of life among people with multiple sclerosis. The Journal of Rural Health, 24(3), 244–252.PubMedCrossRef
22.
Gullo, H. L., et al. (2019). Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis. Mult Scler Relat Disord, 31, 118–123.PubMedCrossRef
23.
Janssens, A. C., et al. (2003). Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Multiple Sclerosis, 9(4), 397–403.PubMedCrossRef
24.
Sander, L., Kugler, J., & Elsner, B. (2020). The influence of multiple sclerosis-related symptoms on health-related quality of life. Fortschritte der Neurologie-Psychiatrie, 88(11), 704–712.PubMed
25.
Abdullah, E. J., & Badr, H. E. (2018). Assessing the quality of life in patients with multiple sclerosis in Kuwait: A cross sectional study. Psychology, Health & Medicine, 23(4), 391–399.CrossRef
26.
Jones, E., et al. (2016). Quantifying the relationship between increased disability and health care resource utilization, quality of life, work productivity, health care costs in patients with multiple sclerosis in the US. BMC Health Services Research, 16, 294.PubMedPubMedCentralCrossRef
27.
Andrees, V., et al. (2019). Towards patients’ understanding of health-related quality of life-a mixed-method study in psoriasis and multiple sclerosis. Quality of Life Research, 28(10), 2717–2729.PubMedCrossRef
28.
Buchanan, R. J., Huang, C., & Chakravorty, B. J. (2011). Health-related quality of life among African Americans with multiple sclerosis. Ethnicity and Disease, 21(3), 377–384.PubMed
29.
Buchanan, R. J., et al. (2012). Health-related quality of life among Latinos with multiple sclerosis. Journal of Social Work in Disability & Rehabilitation, 11(4), 240–257.CrossRef
30.
Cioncoloni, D., et al., Individual factors enhance poor health-related quality of life outcome in multiple sclerosis patients. Significance of predictive determinants. J Neurol Sci, 2014. 345(1–2): p. 213–9.
31.
Hyarat, S. Y., et al. (2019). Health Related Quality of Life Among Patients With Multiple Sclerosis: The Role of Psychosocial Adjustment to Illness. Archives of Psychiatric Nursing, 33(1), 11–16.PubMedCrossRef
32.
Marrie, R., et al. (2008). Comorbidity, socioeconomic status and multiple sclerosis. Multiple Sclerosis, 14(8), 1091–1098.PubMedCrossRef
33.
34.
Overs, S., et al. (2012). Modifiable comorbidities and disability in multiple sclerosis. Current Neurology and Neuroscience Reports, 12(5), 610–617.PubMedCrossRef
35.
Tettey, P., et al. (2016). Frequency of Comorbidities and Their Association with Clinical Disability and Relapse in Multiple Sclerosis. Neuroepidemiology, 46(2), 106–113.PubMedCrossRef
36.
37.
Zivadinov, R., et al. (2016). Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis. AJNR. American Journal of Neuroradiology, 37(6), 1010–1016.PubMedPubMedCentralCrossRef
38.
39.
Thormann, A., et al. (2017). Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mortality. Neurology, 89(16), 1668–1675.PubMedCrossRef
40.
41.
42.
Gromisch, E. S., et al. (2020). Who is not coming to clinic? A predictive model of excessive missed appointments in persons with multiple sclerosis. Mult Scler Relat Disord, 38, 101513.PubMedCrossRef
43.
Warren, S. A., et al. (2009). Comorbidity and health-related quality of life in people with multiple sclerosis. Int J MS Care, 11, 6–16.CrossRef
44.
Marrie, R. A., et al. (2012). Cumulative impact of comorbidity on quality of life in MS. Acta Neurologica Scandinavica, 125(3), 180–186.PubMedCrossRef
45.
Lo, L. M. P., et al. (2021). Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis. Journal of Neurology, 268(2), 569–581.PubMedCrossRef
46.
Marck, C. H., et al. (2016). Prevalence of Comorbidities, Overweight and Obesity in an International Sample of People with Multiple Sclerosis and Associations with Modifiable Lifestyle Factors. PLoS ONE, 11(2), e0148573.PubMedPubMedCentralCrossRef
47.
Koltuniuk, A., et al. (2022). The quality of life in patients with multiple sclerosis - Association with depressive symptoms and physical disability: A prospective and observational study. Frontiers in Psychology, 13, 1068421.PubMedCrossRef
48.
Schmidt, S., & Jostingmeyer, P. (2019). Depression, fatigue and disability are independently associated with quality of life in patients with multiple Sclerosis: Results of a cross-sectional study. Mult Scler Relat Disord, 35, 262–269.PubMedCrossRef
49.
Carta, M. G., et al. (2014). Multiple sclerosis and bipolar disorders: The burden of comorbidity and its consequences on quality of life. Journal of Affective Disorders, 167, 192–197.PubMedCrossRef
50.
Yalachkov, Y., et al. (2019). Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis. Mult Scler Relat Disord, 30, 33–37.PubMedCrossRef
51.
Marrie, R. A., et al. (2010). Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology, 74(13), 1041–1047.PubMedPubMedCentralCrossRef
52.
Puz, P., et al. (2018). Effect of comorbidities on the course of multiple sclerosis. Clinical Neurology and Neurosurgery, 167, 76–81.PubMedCrossRef
53.
Fitzgerald, K.C., et al., Vascular comorbidity is associated with lower brain volumes and lower neuroperformance in a large multiple sclerosis cohort. Mult Scler, 2021: p. 1352458520984746.
54.
Marrie, R. A., et al. (2022). Effects of Vascular Comorbidity on Cognition in Multiple Sclerosis Are Partially Mediated by Changes in Brain Structure. Frontiers in Neurology, 13, 910014.PubMedPubMedCentralCrossRef
55.
Jakimovski, D., et al. (2019). Hypertension and heart disease are associated with development of brain atrophy in multiple sclerosis: A 5-year longitudinal study. European Journal of Neurology, 26(1), 87-e8.PubMedCrossRef
56.
Dagan, A., et al. (2016). Disability Progression in Multiple Sclerosis Is Affected by the Emergence of Comorbid Arterial Hypertension. Journal of Clinical Neurology, 12(3), 345–50.PubMedPubMedCentralCrossRef
57.
Geraldes, R., et al. (2020). Vascular disease and multiple sclerosis: A post-mortem study exploring their relationships. Brain, 143(10), 2998–3012.PubMedCrossRef
58.
Tettey, P., et al. (2017). An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event. Journal of Neurology, Neurosurgery and Psychiatry, 88(5), 395–401.PubMedCrossRef
59.
Conway, D. S., Thompson, N. R., & Cohen, J. A. (2017). Influence of hypertension, diabetes, hyperlipidemia, and obstructive lung disease on multiple sclerosis disease course. Multiple Sclerosis, 23(2), 277–285.PubMedCrossRef
60.
Marrie, R. A., Cutter, G., & Tyry, T. (2011). Substantial adverse association of visual and vascular comorbidities on visual disability in multiple sclerosis. Multiple Sclerosis, 17(12), 1464–71.PubMedCrossRef
61.
Gromisch ES, Neto LO, and T. AP., What biopsychosocial factors explain self-management behaviors in multiple sclerosis? The role of demographics, cognition, personality, and psychosocial and physical functioning. Arch Phys Med Rehabil, 2021.
62.
Palladino, R., et al. (2020). Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England. JAMA Neurology, 77(7), 820–828.PubMedCrossRef
63.
Roshanisefat, H., et al. (2014). Multiple sclerosis clinical course and cardiovascular disease risk - Swedish cohort study. European Journal of Neurology, 21(11), 1353-e88.PubMedCrossRef
64.
Marrie, R. A., et al. (2012). Rising prevalence of vascular comorbidities in multiple sclerosis: Validation of administrative definitions for diabetes, hypertension, and hyperlipidemia. Multiple Sclerosis, 18(9), 1310–9.PubMedCrossRef
65.
Palladino, R., et al. (2023). Management of vascular risk in people with multiple sclerosis at the time of diagnosis in England: A population-based study. Multiple Sclerosis, 29(6), 671–679.PubMedCrossRef
66.
Harris, P. A., et al. (2019). The REDCap consortium: Building an international community of software platform partners. Journal of Biomedical Informatics, 95, 103208.PubMedPubMedCentralCrossRef
67.
Harris, P. A., et al. (2009). Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics, 42(2), 377–81.PubMedCrossRef
68.
Field, A., & Discovering statistics using SPSS, third edition. London, UK: Sage Publications Ltd. third edition, (Eds.). (2009). London. Sage Publications Ltd.
69.
Hohol, M. J., Orav, E. J., & Weiner, H. L. (1995). Disease steps in multiple sclerosis: A simple approach to evaluate disease progression. Neurology, 45(2), 251–5.PubMedCrossRef
70.
Hohol, M. J., Orav, E. J., & Weiner, H. L. (1999). Disease steps in multiple sclerosis: A longitudinal study comparing disease steps and EDSS to evaluate disease progression. Multiple Sclerosis, 5(5), 349–54.PubMedCrossRef
71.
Learmonth, Y. C., et al. (2013). Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis. BMC Neurology, 13, 37.PubMedPubMedCentralCrossRef
72.
Marrie, R. A., & Goldman, M. (2007). Validity of performance scales for disability assessment in multiple sclerosis. Multiple Sclerosis, 13(9), 1176–82.PubMedCrossRef
73.
74.
Rosato, R., et al., eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54. Mult Scler, 2018: p. 1352458518774935.
75.
Rosato, R., et al. (2019). eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54. Multiple Sclerosis, 25(6), 856–866.PubMedCrossRef
76.
Baker, G., et al. (2019). Reliability and acceptability of the Multiple Sclerosis Quality of Life-29 questionnaire in an English-speaking cohort. Multiple Sclerosis, 25(11), 1539–1542.PubMedCrossRef
77.
Lo, L.M.P., et al., Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis. Journal of Neurology, 2020.
78.
Christman, A. L., et al. (2010). Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample. Archives of Clinical Neuropsychology, 25(1), 49–59.PubMedCrossRef
79.
Hajjar, I., et al. (2016). Racial Disparity in Cognitive and Functional Disability in Hypertension and All-Cause Mortality. American Journal of Hypertension, 29(2), 185–93.PubMedCrossRef
80.
Stough, C., et al. (2019). Increases in total cholesterol and low density lipoprotein associated with decreased cognitive performance in healthy elderly adults. Metabolic Brain Disease, 34(2), 477–484.PubMedCrossRef
81.
Fitzgerald, K. C., et al. (2021). Vascular comorbidity is associated with lower brain volumes and lower neuroperformance in a large multiple sclerosis cohort. Multiple Sclerosis, 27(12), 1914–1923.PubMedCrossRef
82.
Nelson, R. H. (2013). Hyperlipidemia as a risk factor for cardiovascular disease. Primary Care, 40(1), 195–211.PubMedCrossRef
83.
Briggs, F. B. S., Hill, E., & Abboud, H. (2021). The prevalence of hypertension in multiple sclerosis based on 37 million electronic health records from the United States. European Journal of Neurology, 28(2), 558–566.PubMedCrossRef
84.
Horton, M., et al. (2010). Validation of a self-report comorbidity questionnaire for multiple sclerosis. Neuroepidemiology, 35(2), 83–90.PubMedCrossRef
85.
Marrie, R. A., et al. (2016). Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis. Brain and Behavior: A Cognitive Neuroscience Perspective, 6(9), e00493.CrossRef
Metagegevens
Titel
Perceived health- related quality of life in persons with multiple sclerosis with and without a vascular comorbidity
Auteurs
Lindsay O. Neto
Jennifer A. Ruiz
Elizabeth S. Gromisch
Publicatiedatum
15-11-2023
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2024
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-023-03546-3

Andere artikelen Uitgave 2/2024

The effect of depressive symptoms on quality of life and its different facets in the oldest age population: evidence from the AgeQualiDe prospective cohort study

  • Open Access

"not one size fits all” The challenges of measuring paediatric health-related quality of life and the potential role of digital ecological momentary assessment: a qualitative study

  • Open Access

Personal and perceived stigma in relation to diverse domains of quality of life among patients with major depressive disorder having residual symptoms: a hospital-based cross-sectional study in Thailand

Health-related quality of life (HRQoL) after different axillary treatments in women with breast cancer: a 1-year longitudinal cohort study

  • Open Access

A concept elicitation study to understand the relationship between sleep and pain in rheumatoid arthritis and axial spondyloarthritis

  • Open Access

Mapping the 12-item World Health Organization disability assessment schedule 2.0 (WHODAS 2.0) onto the assessment of quality of life (AQoL)-4D utilities

  • Open Access