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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2006 | Original Paper

Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study

Auteurs: Cindy K. Schneider, Raun D. Melmed, Leon E. Barstow, F. Javier Enriquez, James Ranger-Moore, James A. Ostrem

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2006

Abstract

Immunoglobulin secretion onto mucosal surfaces is a major component of the mucosal immune system. We hypothesized that chronic gastrointestinal (GI) disturbances associated with autistic disorder (AD) may be due to an underlying deficiency in mucosal immunity, and that orally administered immunoglobulin would be effective in alleviating chronic GI dysfunction in these individuals. In this pilot study, twelve male subjects diagnosed with AD were evaluated using a GI severity index (GSI) while receiving daily dosing with encapsulated human immunoglobulin. Following eight weeks of treatment, 50% of the subjects met prespecified criteria for response in GI signs and symptoms and showed significant behavioral improvement as assessed by the Autism Behavior Checklist and parent and physician rated Clinical Global Impression of Improvement.

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Titel: Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study
Auteurs: Cindy K. Schneider
Raun D. Melmed
Leon E. Barstow
F. Javier Enriquez
James Ranger-Moore
James A. Ostrem
Publicatiedatum: 01-11-2006
Uitgeverij: Kluwer Academic Publishers-Plenum Publishers
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0141-y

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