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18-01-2019

Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease: a cross-sectional study from the CKD-REIN cohort study

Auteurs: M. L. Schweitzer, B. Stengel, K. Legrand, S. Briançon, C. Jacquelinet, C. Combe, D. Fouque, Z. A. Massy, M. Laville, L. Frimat, C. Ayav

Gepubliceerd in: Quality of Life Research | Uitgave 7/2019

Abstract

Purpose

To evaluate the association between obesity phenotypes and health-related quality of life (HRQoL) in non-dialysis-dependent CKD patients.

Methods

Data from the national CKD-REIN cohort which included 3033 patients with stage 3–4 CKD were used. Patients were divided into three groups: non-obese (NO) patients (BMI < 30 kg/m²), metabolically healthy obese (MHO) (BMI ≥ 30 kg/m² and ≤ 1 criterion NCEP/ATP III), and metabolically unhealthy obese (MUO) (BMI ≥ 30 kg/m² and ≥ 2 criteria NCEP/ATP III). HRQoL was measured by the KDQOL-36™ which comprised three disease-specific dimensions: symptoms, effects, and burden and two summaries scores: physical (PCS) and mental (MCS). We used a mixed effect model with adjustment on sociodemographic characteristics and comorbidities.

Results

A total of 2693 patients completed the self-administered questionnaires. MHO patients accounted for 3.4% of the cohort and for 12% of obese patients. In the NO group, average HRQoL scores were 77.2 ± 15.9 for symptoms, 83.5 ± 16.5 for effects, 76.8 ± 22.7 for burden, 43.5 ± 9.7 for PCS, and 47.9 ± 7.0 for MCS. In the multivariate analysis, scores were similar in MHO and NO patients, but significantly different with those in MUO patients: symptoms (− 0.7; p = 0.71 vs. − 3.0; p = 0.0025), effects (+ 1.2; p = 0.57 vs. − 4.3; p < 0.0001), burden (+ 2.7; p = 0.31 vs. − 3.6; p = 0.0031), and PCS (− 0.6; p = 0.58 vs. − 4.3; p < 0.0001). MCS was not associated with obesity phenotypes.

Conclusions

This study demonstrated an association between obesity phenotypes and QoL in non-dialysis-dependent CKD patients. MUO patients had worse QoL than NO and MHO patients even after adjustment on comorbidities.

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Titel: Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease: a cross-sectional study from the CKD-REIN cohort study
Auteurs: M. L. Schweitzer
B. Stengel
K. Legrand
S. Briançon
C. Jacquelinet
C. Combe
D. Fouque
Z. A. Massy
M. Laville
L. Frimat
C. Ayav
Publicatiedatum: 18-01-2019
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 7/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-019-02110-2

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Abstract

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