Swipe om te navigeren naar een ander artikel
Dysregulated processing of natural rewards may be a central pathogenic process in the etiology and maintenance of prescription opioid misuse and addiction among chronic pain patients. This study examined whether a Mindfulness-Oriented Recovery Enhancement (MORE) intervention could augment natural reward processing through training in savoring as indicated by event-related brain potentials (ERPs). Participants were chronic pain patients at risk for opioid misuse who were randomized to 8 weeks of MORE (n = 11) or a support group control condition (n = 18). ERPs to images representing naturally rewarding stimuli (e.g., beautiful landscapes, intimate couples) and neutral images were measured before and after 8 weeks of treatment. Analyses focused on the late positive potential (LPP)—an ERP response in the 400–1,000 ms time window thought to index allocation of attention to emotional information. Treatment with MORE was associated with significant increases in LPP response to natural reward stimuli relative to neutral stimuli which were correlated with enhanced positive affective cue-responses and reductions in opioid craving from pre- to post-treatment. Findings suggest that cognitive training regimens centered on strengthening attention to natural rewards may remediate reward processing deficits underpinning addictive behavior.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Chou, R., Fanciullo, G. J., Fine, P. G., Adler, J. A., Ballantyne, J. C., Davies, P., … Miaskowski, C. (2009). Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. The Journal of Pain, 10, 113–130.
Davidson, R. J., Kabat-Zinn, J., Schumacher, J., Rosenkranz, M., Muller, D., Santorelli, S. F., … Sheridan, J. F. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65, 564–70.
Garland, E. L. (2013). Mindfulness-Oriented Recovery Enhancement for addiction, stress, and pain. Washington, DC: NASW Press.
Garland, E. L., Fredrickson, B. L., Kring, A. M., Johnson, D. P., Meyer, P. S., & Penn, D. L. (2010a). Upward spirals of positive emotions counter downward spirals of negativity: Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology. Clinical Psychology Review, 30, 849–864. CrossRefPubMedCentralPubMed
Garland, E. L., Froeliger, B., & Howard, M. (2014a). Mindfulness training targets neurocognitive mechanisms of addiction at the attention–appraisal–emotion interface. Frontiers in Psychiatry, 4, 173. doi: 10.3389/fpsyt.2013.00173
Garland, E. L., Froeliger, B., & Howard, M. O. (2014b). Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology. doi: 10.1007/s00213-014-3504-7
Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O. (2013). The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways. Neuroscience and Biobehavioral Reviews, 37, 2597–2607. CrossRefPubMedCentralPubMed
Garland, E. L., Gaylord, S. A., Boettiger, C. A., & Howard, M. O. (2010b). Mindfulness training modifies cognitive, affective, and physiological mechanisms implicated in alcohol dependence: Results from a randomized controlled pilot trial. Journal of Psychoactive Drugs, 42, 177–192. CrossRefPubMedCentralPubMed
Garland, E. L., Manusov, E. G., Froeliger, B., Kelly, A., Williams, J., & Howard, M. O. (2014c). Mindfulness-Oriented Recovery Enhancement for chronic pain and prescription opioid misuse: Results from an early stage randomized controlled trial. Journal of Consulting and Clinical Psychology. doi: 10.1037/a0035798
Gipson, C. D., Reissner, K. J., Kupchik, Y. M., Smith, A. C., Stankeviciute, N., Hensley-Simon, M. E., & Kalivas, P. W. (2013). Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proceedings of the National Academy of the Sciences United States of America, 110, 9124–9129. CrossRef
Gootjes, L., Franken, I. H. A., & Van Strien, J. W. (2011). Cognitive emotion regulation in yogic meditative practitioners. Journal of Psychophysiology, 25, 87–94. doi: 10.1027/0269-8803/a000043
Hagerty, M. R., Isaacs, J., Brasington, L., Shupe, L., Fetz, E. E., & Cramer, S. C. (2013). Case study of ecstatic meditation: fMRI and EEG evidence of self-stimulating a reward system. Neural Plasticity, 2013. doi: 10.1155/2013/653572
Hajcak, G., & Nieuwenhuis, S. (2006). Reappraisal modulates the electrocortical response to unpleasant pictures. Cognitive, Affective, & Behavioral Neuroscience, 6, 291–297. CrossRef
Heiman, J. R., & Meston, C. M. (1998). Empirically validated treatments for sexual dysfunction. In R. C. Rosen, C. M. Davis, & H. J. Ruppel (Eds.), Annual review of sex research: An integrative and interdisciplinary review 1997 (Vol. 8, pp. 148–194). Mason City, IA: The Society for the Scientific Study of Sexuality.
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D., & Ott, U. (2011). How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspectives on Psychological Science, 6, 537–559. CrossRef
Hong, P. Y., Lishner, D. A., & Han, K. H. (2014). Mindfulness and eating: An experiment examining the effect of mindful raisin eating on the enjoyment of sampled food. Mindfulness, 5, 80–87. CrossRef
Hong, P. Y., Lishner, D. A., Han, K. H., & Huss, E. A. (2011). The positive impact of mindful eating on expectations of food liking. Mindfulness, 2, 103–113. CrossRef
Kober, H., Mende-Siedlecki, P., Kross, E. F., Weber, J., Mischel, W., Hart, C. L., & Ochsner, K. N. (2011). Prefrontal-striatal pathway underlies cognitive regulation of craving. Proceedings of the National Academy of Sciences United States of America, 107, 14811–14816.
Koob, G. F., & Le Moal, M. (2008). Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3113–3123. CrossRef
Lang, P., Bradley, M., & Cuthbert, B. (1997). International affective picture system (IAPS): Technical manual and affective ratings. Gainesville, FL: NIMH Center for the Study of Emotion and Attention.
LeBel, J. L., & Dubé, L. (2001). The impact of sensory knowledge and attentional focus on pleasure and on behavioral responses to hedonic stimuli. 13th annual American Psychological Society convention, Toronto, ON.
Lee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., … Mandelkern, M. A. (2009). Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. Journal of Neuroscience 29, 14734–14740.
Lintas, A., Chi, N., Lauzon, N. M., Bishop, S. F., Sun, N., Tan, H., & Laviolette, S. R. (2012). Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. European Journal of Neuroscience, 35, 279–290.
Liu, Y., Huang, H., McGinnis-Deweese, M., Keil, A., & Ding, M. (2012). Neural substrate of the late positive potential in emotional processing. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32, 14563–14572. CrossRef
Lubman, D. I., Yucel, M., Kettle, J. W., Scaffidi, A., Mackenzie, T., Simmons, J. G., & Allen, N. B. (2009). Responsiveness to drug cues and natural rewards in opiate addiction: Associations with later heroin use. Archives of General Psychiatry, 66, 205–212.
Masters, W. H., & Johnson, V. E. (1970). Human sexual inadequacy. Boston: Little & Brown.
Moser, J. S., Krompinger, J. W., Dietz, J., & Simons, R. F. (2009). Electrophysiological correlates of decreasing and increasing emotional responses to unpleasant pictures. Psychophysiology, 46(1), 17–27.
Olofsson, J. K., Nordin, S., Sequeira, H., & Polich, J. (2008). Affective picture processing: An integrative review of ERP findings. Biological Psychology, 77, 247–265. doi: 10.1016/j.biopsycho.2007.11.006
Rawson, R., & McCann, M. J. (2006) . Counselor’s treatment manual: Matrix intensive outpatient treatment for people with stimulant use disorders. DHHS publication no. (SMA). Washington DC: SAMHSA.
Rogers, C. (2003). Client-centered therapy: Its current practice, implications, and theory. New York: Constable.
Schönfelder, S., Kanske, P., Heissler, J., & Wessa, M. (2013). Time course of emotion-related responding during distraction and reappraisal. Social Cognitive and Affective Neuroscience, nst116. doi: 10.1093/scan/nst116
Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., … Dunbar, G. C. (1998). The mini-international neuropsychiatric interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59, 22–33.
Shizgal, P., & Hyman S. P. (2013). Motivational and addictive states. In E. R. Kandel, J. H. Schwartz, T. M. Jessell, S. Siegelbaum, & J. Hudspeth (Eds.), Principles of neural science (5th edn.). New York: McGraw-Hill.
Shurman, J., Koob, G. F., & Gutstein, H. B. (2010). Opioids, pain, the brain, and hyperkatifeia: A framework for the rational use of opioids for pain. Pain Medicine (Malden, Massachusetts), 11, 1092–1098. CrossRef
- Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT
Eric L. Garland
Matthew O. Howard
- Springer US