Skip to main content
Top
Gepubliceerd in:

07-01-2016 | Artikel

Mechanismen van impulsiviteit in neurologie en psychiatrie: recente ontwikkelingen in translationeel preklinisch onderzoek

Auteur: Tommy Pattij

Gepubliceerd in: Neuropraxis | Uitgave 2/2016

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Verhoogde impulsiviteit is een kernsymptoom in verschillende psychiatrische en neurologische aandoeningen en wordt gekenmerkt door verstoringen in cognitieve controle en impulsieve beslissingen. Naast nieuwe toepassingen en mogelijkheden in humaan neuroimagingonderzoek, heeft vooral translationeel preklinisch onderzoek veel opgehelderd over de neurobiologie van impulsiviteit. Farmacologische interventies hebben het belang laten zien van de neurotransmitters serotonine, dopamine en noradrenaline in het reguleren van impulsief gedrag. De intrede van zeer geavanceerde technologieën in de neurowetenschappen, zoals de optogenetica en farmacogenetica, stelt ons in staat om grote sprongen voorwaarts te maken in het ontrafelen van de neurobiologie van impulsiviteit.
Literatuur
1.
go back to reference Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–45.CrossRefPubMed Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–45.CrossRefPubMed
2.
go back to reference Linnoila M, Virkkunen M, Scheinin M, et al. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33:2609–14.CrossRefPubMed Linnoila M, Virkkunen M, Scheinin M, et al. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33:2609–14.CrossRefPubMed
4.
go back to reference Wiskerke J, Schetters D, Van Es IE, et al. µ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice. J Neurosci. 2011;31:262–72.CrossRefPubMed Wiskerke J, Schetters D, Van Es IE, et al. µ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice. J Neurosci. 2011;31:262–72.CrossRefPubMed
5.
go back to reference Wiskerke J, Stoop N, Schetters D, et al. Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice. PLoS One. 2011;6:e25856.CrossRefPubMedPubMedCentral Wiskerke J, Stoop N, Schetters D, et al. Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice. PLoS One. 2011;6:e25856.CrossRefPubMedPubMedCentral
6.
go back to reference Pattij T, Schetters D, Schoffelmeer AN, et al. On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists. Psychopharmacology (Berl). 2012;219:327–40.CrossRef Pattij T, Schetters D, Schoffelmeer AN, et al. On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists. Psychopharmacology (Berl). 2012;219:327–40.CrossRef
7.
go back to reference Wachter SB, Gilbert EM. Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application. Cardiology. 2012;122:104–12.CrossRefPubMed Wachter SB, Gilbert EM. Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application. Cardiology. 2012;122:104–12.CrossRefPubMed
8.
go back to reference Steinberg EE, Christoffel DJ, Deisseroth K, et al. Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol. 2015;30:9–16.CrossRefPubMed Steinberg EE, Christoffel DJ, Deisseroth K, et al. Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol. 2015;30:9–16.CrossRefPubMed
9.
go back to reference Saddoris MP, Sugam JA, Stuber GD, et al. Mesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making. Biol Psychiatry. 2015;77:903–11.CrossRefPubMed Saddoris MP, Sugam JA, Stuber GD, et al. Mesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making. Biol Psychiatry. 2015;77:903–11.CrossRefPubMed
10.
go back to reference Friedman A, Homma D, Gibb LG, et al. A corticostriatal path targeting striosomes controls decision-making under conflict. Cell. 2015;161:1320–33.CrossRefPubMed Friedman A, Homma D, Gibb LG, et al. A corticostriatal path targeting striosomes controls decision-making under conflict. Cell. 2015;161:1320–33.CrossRefPubMed
11.
go back to reference Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol. 2015;55:399–417.CrossRefPubMed Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol. 2015;55:399–417.CrossRefPubMed
12.
go back to reference Koike H, Demars MP, Short JA, et al. Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse. Neuropsychopharmacology. 2015.doi:10.1038/npp.2015.229. Koike H, Demars MP, Short JA, et al. Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse. Neuropsychopharmacology. 2015.doi:10.1038/npp.2015.229.
13.
go back to reference Ward RD, Winiger, V, Kandel ER, et al. Orbitofrontal cortex mediates the differential impact of signaled-reward probability on discrimination accuracy. Front Neurosci. 2015;9:230.CrossRefPubMedPubMedCentral Ward RD, Winiger, V, Kandel ER, et al. Orbitofrontal cortex mediates the differential impact of signaled-reward probability on discrimination accuracy. Front Neurosci. 2015;9:230.CrossRefPubMedPubMedCentral
14.
go back to reference Krack P, Hariz MI, Baunez C, et al. Deep brain stimulation: from neurology to psychiatry? Trends Neurosci. 2010;33:474–84.CrossRefPubMed Krack P, Hariz MI, Baunez C, et al. Deep brain stimulation: from neurology to psychiatry? Trends Neurosci. 2010;33:474–84.CrossRefPubMed
Metagegevens
Titel
Mechanismen van impulsiviteit in neurologie en psychiatrie: recente ontwikkelingen in translationeel preklinisch onderzoek
Auteur
Tommy Pattij
Publicatiedatum
07-01-2016
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 2/2016
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-015-0111-2

Andere artikelen Uitgave 2/2016

Neuropraxis 2/2016 Naar de uitgave