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20-04-2016

Linking childhood abuse and hypertension: sleep disturbance and inflammation as mediators

Auteurs: Megan E. Petrov, Mary C. Davis, Michael J. Belyea, Alex J. Zautra

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 4/2016

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Abstract

The indirect association of childhood abuse with prevalent hypertension in adulthood through sleep disturbance and pro-inflammatory biomarkers was investigated in 589 community-dwelling, middle-aged adults. Participants completed the Childhood Trauma Questionnaire and self-reported current sleep disturbance and medical diagnoses including hypertension. Blood pressure was taken and blood samples were analyzed for C-reactive protein, interleukin-6, and fibrinogen. Hypertension was present in 41.3 % of the sample. In the full multiple mediation model, tested using structural equation modeling, all hypothesized pathways were significant (p’s < 0.05). Childhood abuse was significantly related to both body mass index and sleep disturbance, which, both in turn, were significantly associated with inflammation, which was subsequently associated with hypertension status. The model demonstrated good fit [χ2 (122) = 352.0, p < 0.001, CFI = 0.918, RMSEA = 0.057] and the indirect effect of all mediators was significant (indirect effect: 0.02, 95 % CI 0.005–0.03, p = 0.001). Sleep disturbance, body mass, and inflammation may be independent, intermediate steps between childhood abuse and subsequent hypertension that may be amenable to biobehavioral interventions.
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Metagegevens
Titel
Linking childhood abuse and hypertension: sleep disturbance and inflammation as mediators
Auteurs
Megan E. Petrov
Mary C. Davis
Michael J. Belyea
Alex J. Zautra
Publicatiedatum
20-04-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 4/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-016-9742-x