Top

Gepubliceerd in:

01-08-2012

Choice and placebo expectation effects in the context of pain analgesia

Auteurs: Jason P. Rose, Andrew L. Geers, Heather M. Rasinski, Stephanie L. Fowler

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 4/2012

Abstract

The current experiment examined whether having choice over treatment options facilitates or inhibits the strength of placebo expectations in the context of pain perception. All participants were exposed to an aversive stimulus (i.e., the cold pressor task), and participants in some conditions were given expectations for two pain-relieving treatments (actually the same inert ointment mixture). Critically, participants in these expectation conditions were also given a choice or not about which of the two treatments they preferred to use. Participants in a control condition were not provided with a treatment expectation. Despite receiving the same inert treatment, participants who had a choice over treatments showed increased placebo analgesia as compared to participants not given a choice and participants in the control condition. Moreover, this effect was mediated by changes in anxiety. Explanations and implications for these results are discussed.

vorige artikel An affective booster moderates the effect of gain- and loss-framed messages on behavioral intentions for colorectal cancer screening

Given that we did not extensively prescreen for chronic pain or other health conditions in this college sample, the inclusion of a baseline pain measure allowed us to control for any pre-existing differences in our analyses. It is notable that mean baseline levels of pain did not differ across conditions (F [2, 38] = .05, P > .90) nor did they violate homogeneity of variance assumptions across conditions (Levene’s Statistic = .032, P > .90).

Some readers may still wonder about potential interpretation problems when measuring expectations after the cold pressor task, as opposed to immediately after the manipulation of expectations. First, it should be noted that there is precedence for measuring expectations later in the study to avoid any possible contamination that explicitly thinking about expectations could have on a primary dependent variable (e.g., Geers et al., 2006; Geers et al., 2010). Moreover, although choice and no choice participants reported similar pain expectations on the manipulation-check item, their self-reported pain did differ from one another. This finding suggests that the manipulation-check responses, obtained near the end of the experiment, were not primarily determined by participants’ pain experiences and reports regarding the cold pressor task.

Benedetti, F. (2008). Mechanisms of placebo and placebo-related effects across diseases and treatments. Annual Review of Pharmacology and Toxicology, 48, 33–60.CrossRefPubMed

Bienenfeld, L., Frishman, W., & Glasser, S. P. (1996). The placebo effect in cardiovascular disease. American Heart Journal, 132, 1207–1221.CrossRefPubMed

Brehm, J. W. (1956). Post-decision changes in the desirability of choice alternatives. Journal of Abnormal and Social Psychology, 52, 384–389.CrossRef

Burger, J. M. (1989). Negative reactions to increases in perceived personal control. Journal of Personality and Social Psychology, 35, 351–363.

Chilvers, C., Dewey, M., Fielding, K., Gretton, V., Miller, P., Palmer, B., et al. (2001). Antidepressant drugs and generic counseling for treatment of major depression in primary care: Randomized trial with patient preference arms. British Medical Journal, 322, 722–775.CrossRef

Devine, D. A., & Fernald, P. S. (1973). Outcome effects of receiving a preferred, randomized assigned, or nonpreferred therapy. Journal of Consulting and Clinical Psychology, 41, 104–107.CrossRefPubMed

Fallowfield, L. J., Hall, A., Maguire, G. P., & Baum, M. (1990). Psychological outcomes of different treatment policies in women with early stage breast cancer outside a clinical trial. British Medical Journal, 301, 575–580.CrossRefPubMed

Gattellari, M., Butow, P. N., & Tattersall, M. H. N. (2001). Sharing decisions in cancer care. Social Science and Medicine, 52, 1865–1878.CrossRefPubMed

Geers, A. L., Helfer, S. G., Kosbab, K., & Weiland, P. E. (2006). Expectations and placebo response: A laboratory investigation into the role of somatic focus. Journal of Behavioral Medicine, 29, 171–178.CrossRefPubMed

Geers, A. L., & Rose, J.P. (in press). Treatment choice and placebo expectation effects. Social and Personality Psychology Compass.

Geers, A. L., Rose, J. P., Fowler, S. L., & Rasinski, H. M. (2011a). Lay beliefs about treatment choice in the context of placebo effects. Toledo, OH: Unpublished raw data.

Geers, A. L., Wellman, J. A., Fowler, S. L., Helfer, S. G., & France, C. R. (2010). Dispositional optimism predicts placebo analgesia. The Journal of Pain, 11, 1165–1171.CrossRefPubMed

Geers, A. L., Wellman, J. A., Fowler, S. L., Rasinski, H. M., & Helfer, S. G. (2011b). Placebo expectations and the detection of somatic information. Journal of Behavioral Medicine, 34, 208–217.CrossRefPubMed

Geers, A. L., Wellman, J. A., Helfer, S. G., Fowler, S. L., & France, C. R. (2008). Dispositional optimism and thoughts of well-being determine sensitivity to an experimental pain task. Annals of Behavioral Medicine, 36, 304–313.CrossRefPubMed

Gordon, R. B. (1976). Effects of volunteering and responsibility on the perceived value and effectiveness of a clinical treatment. Journal of Consulting and Clinical Psychology, 44, 799–801.CrossRefPubMed

Hack, T. F., Degner, L. F., Watson, P., & Sinha, L. (2006). Do patients benefit from participating in medical decision making? Longitudinal follow-up of women with breast cancer. Psycho-Oncology, 15, 9–19.CrossRefPubMed

Hammersley, R., Finnigan, F., & Millar, K. (1998). Verbal expectancies and performance after alcohol. Addictive Behaviors, 23, 489–496.CrossRefPubMed

Handelzalts, J. E., & Keinan, G. (2010). The effect of choice between test anxiety options on treatment outcomes. Psychotherapy Research, 20, 100–112.CrossRefPubMed

Harmon-Jones, E., & Mills, J. (Eds.). (1999). Cognitive dissonance: Progress on a pivotal theory in social psychology. Washington, DC: American Psychological Association.

Harrington, A. (1999). The placebo effect: An interdisciplinary phenomenon. Cambridge: Harvard University Press.

Hart, W., Albarracín, D., Eagly, A. H., Brechan, I., Lindberg, M. J., & Merrill, L. (2009). Feeling validated versus being correct: A meta-analysis of selective exposure to information. Psychological Bulletin, 135, 555–588.CrossRefPubMed

Hróbjartsson, A., & Gotzsche, P. C. (2001). Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. New England Journal of Medicine, 344, 1594–1601.CrossRefPubMed

Hróbjartsson, A., & Gotzsche, P. C. (2004). Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no-treatment. Journal of International Medicine, 256, 91–100.

Hyland, M. E. (2011). Motivation and placebos: do different mechanisms occur in different contexts? Philosophical Transactions B, 366, 1828–1837.CrossRef

Iyengar, S., & Lepper, M. (2000). When choice is demotivating: Can one desire too much of a good thing? Journal of Personality and Social Psychology, 79, 995–1006.CrossRefPubMed

Kahneman, D., & Tversky, A. (1984). Choices, values, and frames. American Psychologist, 39, 341–350.CrossRef

Kanfer, F. H., & Grimm, L. G. (1978). Freedom of choice and behavioral change. Journal of Consulting and Clinical Psychology, 46, 873–878.CrossRefPubMed

Kenny, D. A., Kashy, D. A., & Bolger, N. (1998). Data analysis in social psychology. In D. Gilbert, S. Fiske, & G. Lindzey (Eds.), The handbook of social psychology (Vol. 1, pp. 233–265). Boston, MA: McGraw-Hill.

Kirsch, I. (1999). How Expectancies Shape Experience. Washington, DC: American Psychological Association.CrossRef

Kirsch, L., & Sapierstein, G. (1998, June). Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication. Prevention and Treatment, 1, Article 0002a. Retrieved April 1, 2002, from http://journals.apa.org/prevention/volume1/pre00100002a.html

Langer, E. J. (1975). The illusion of control. Journal of Personality and Social Psychology, 32, 311–328.CrossRef

Langer, E. J., & Rodin, J. (1976). The effects of choice and enhanced personal responsibility for the aged: A field experiment in an institutional setting. Journal of Personality and Social Psychology, 34, 191–198.CrossRefPubMed

Laska, E., & Sunshine, A. (1977). Anticipation of analgesia: A placebo effect. Headache, 1, 1–11.

Leotti, L. A., Iyengar, S. S., & Ochsner, K. N. (2010). Born to choose: The origins and value of the need for control. Trends in Cognitive Sciences, 14, 457–463.CrossRefPubMed

Mendonca, P. J., & Brehm, S. S. (1983). Effects of choice on behavioral treatment of overweight children. Journal of Social and Clinical Psychology, 1, 343–358.CrossRef

Montgomery, G. H., & Kirsch, I. (1996). Mechanisms of placebo pain reduction: An empirical investigation. Psychological Science, 7, 174–176.CrossRef

Montgomery, G. H., & Kirsch, I. (1997). Classical condition and the placebo effect. Pain, 72, 107–113.CrossRefPubMed

Morris, J., & Royle, G. T. (1988). Offering patients a choice of surgery for early breast cancer: A reduction in anxiety and depression in patients and their husbands. Social Science and Medicine, 26, 583–585.CrossRefPubMed

Moyer, A., & Salovey, P. (1998). Patient participation in treatment decision making and the psychological consequences of breast cancer surgery. Women’s Health: Research on Gender, Behavior, and Policy, 4, 103–116.

Myers, E. D., & Branthwaite, A. (1992). Out-patient compliance with antidepressant medication. British Journal of Psychiatry, 160, 83–86.CrossRefPubMed

Myers, C. D., Tsao, J. C. I., Glover, D. A., Kim, S. C., Turk, N., & Zelter, L. K. (2006). Sex, gender, and age: Contributions to laboratory pain responding in children and adolescence. The Journal of Pain, 7, 556–564.CrossRefPubMed

Nickerson, R. S. (1998). Confirmation bias: A ubiquitous phenomenon in many guises. Review of General Psychology, 2, 175–220.CrossRef

Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., & Carlsson, K. (2005). Placebo in emotional processing-induced expectations of anxiety relief activate a generalized modulatory network. Neuron, 46, 957–969.CrossRefPubMed

Presson, P. K., & Benassi, V. A. (1996). Illusion of control: A meta-analytic review. Journal of Social Behavior and Personality, 11, 493–510.

Price, D. D., & Fields, H. L. (1997). The contribution of desire and expectation to placebo analgesia: Implications for new research strategies. In A. Harrington (Ed.), The placebo effect: an interdisciplinary exploration (pp. 93–116). Cambridge, MA: Harvard University Press.

Price, D. D., Finniss, D. G., & Benedetti, F. (2008). A comprehensive review of the placebo effect: Recent advances and current thought. Annual Review of Psychology, 59, 565–590.CrossRefPubMed

Rief, W., Hofmann, S. G., & Nestoriuc, Y. (2008). The power of expectation—Understanding the placebo and nocebo phenomenon. Social and Personality Psychology Compass, 2, 1624–1637.CrossRef

Riley, J. L., I. I. I., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B. (1998). Sex differences in the perception of noxious experimental stimuli: A meta-analysis. Pain, 74, 181–188.CrossRefPubMed

Rokke, P. D., & al’Absi, M. (1992). Matching pain coping strategies to the individual: A prospective validation of the cognitive coping strategy inventory. Journal of Behavioral Medicine, 15, 611–625.CrossRefPubMed

Rokke, P. D., Fleming-Ficek, S., Siemens, N. M., & Hegstad, H. J. (2004). Self-efficacy and choice of coping strategies for tolerating acute pain. Journal of Behavioral Medicine, 27, 343–360.CrossRefPubMed

Rokke, P. D., & Lall, R. (1992). The role of choice in enhancing tolerance to acute pain. Cognitive Therapy and Research, 16, 53–65.CrossRef

Schulz, R. (1976). Effects of control and predictability on the physical and psychological well-being of the institutionalized aged. Journal of Personality and Social Psychology, 33, 563–573.CrossRefPubMed

Shafir, E., Simonson, I., & Tversky, A. (1993). Reason-based choice. Cognition, 49, 11–36.CrossRefPubMed

Sharot, T., Shiner, T., & Dolan, R. J. (2010). Experience and choice shape expected aversive outcomes. The Journal of Neuroscience, 30, 9209–9215.PubMed

Shelke, A. R., Roscoe, J. A., Morrow, G. R., Colman, L. K., Banerjee, T. K., & Kirshner, J. J. (2008). Effect of a nausea expectancy manipulation on chemotherapy-induced nausea: A University of Rochester cancer center community clinical oncology program study. Journal of Pain and Symptom Management, 35, 381–387.CrossRefPubMed

Smith, S. M., Fabrigar, L. R., & Norris, M. E. (2008). Reflecting on six decades of selective exposure research: Progress, challenges, and opportunities. Social and Personality Psychology Compass, 2, 464–493.CrossRef

Sobel, M. E. (1982). Asymptotic intervals for indirect effects in structural equations models. In S. Leinhart (Ed.), Sociological methodology (pp. 290–312). San Francisco, CA: Jossey-Bass.

Stewart, M., Brown, J. B., Weston, W. W., McWhinney, I. R., McWilliam, C. L., & Freeman, T. R. (2003). Patient-centered medicine: transforming the clinical method (2nd ed.). Abingdon, UK: Radcliffe Medical Press Ltd.

Stewart-Williams, S. (2004). The placebo puzzle: Putting together the pieces. Health Psychology, 23, 198–206.CrossRefPubMed

Stewart-Williams, S., & Podd, J. (2004). The placebo effect: Dissolving the expectancy versus condition debate. Psychological Bulletin, 130, 324–340.CrossRefPubMed

Street, R. L., & Voigt, B. (1997). Patient participation in deciding breast cancer treatment and subsequent quality of life. Medical Decision Making, 17, 298–306.CrossRefPubMed

Turner, J. A., Deyo, R. A., Loeser, J. D., Von Korff, M., & Fordyce, W. E. (1994). The importance of placebo effects in pain treatment and research. Journal of the American Medical Association, 271, 1609–1614.CrossRefPubMed

Vandereycken, W., & Vansteenkiste, M. (2009). Let eating disorder patients decide: Providing choice may reduce early drop-out from impatient treatment. European Eating Disorders Review, 17, 177–183.CrossRefPubMed

Vogel, B. A., Leonhart, R., & Helmes, A. W. (2009). Communication matters: The impact of communication and participation in decision making on breast cancer patients’ depression and quality of life. Patient Education and Counseling, 77, 391–397.CrossRefPubMed

Vohs, K. D., Baumeister, R. F., Schmeichel, B. J., Twenge, J. M., Nelson, N. M., & Tice, D. M. (2008). Making choices impairs subsequent self-control: A limited-resource account of decision making, self-regulation, and active initiative. Journal of Personality and Social Psychology, 94, 883–898.CrossRefPubMed

Voudouris, N. J., Peck, C. L., & Coleman, G. (1990). The role of conditioning and expectancy in the placebo response. Pain, 43, 121–128.CrossRefPubMed

Walach, H., Schmidt, S., Dirhold, T., & Nosch, S. (2002). The effects of a caffeine placebo and suggestion on blood pressure, heart rate, well-being, and cognitive performance. International Journal of Psychophysiology, 43, 247–260.CrossRefPubMed

Worthington, E. L. (1978). The effects of imagery content, choice of imagery content, and self-verbalization on the self-control of pain. Cognitive therapy and Research, 2, 225–240.CrossRef

Titel: Choice and placebo expectation effects in the context of pain analgesia
Auteurs: Jason P. Rose
Andrew L. Geers
Heather M. Rasinski
Stephanie L. Fowler
Publicatiedatum: 01-08-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 4/2012
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-011-9374-0

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 4/2012

Planning and self-efficacy can increase fruit and vegetable consumption: a randomized controlled trial

Beyond conventional socioeconomic status: examining subjective and objective social status with self-reported health among Asian immigrants

Health-specific optimism mediates between objective and perceived physical functioning in older adults

An affective booster moderates the effect of gain- and loss-framed messages on behavioral intentions for colorectal cancer screening

Forgive to Live: Forgiveness, Health, and Longevity

Multiple plans and memory performance: results of a randomized controlled trial targeting fruit and vegetable intake