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Journal of Autism and Developmental Disorders

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01-12-2010 | Original Paper

Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling

Auteurs: Armando Bertone, Julie Hanck, Cary Kogan, Avi Chaudhuri, Kim Cornish

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2010

Abstract

We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed.

vorige artikel Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions

volgende artikel Brief Report: Altered Horizontal Binding of Single Dots to Coherent Motion in Autism

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Titel: Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling
Auteurs: Armando Bertone
Julie Hanck
Cary Kogan
Avi Chaudhuri
Kim Cornish
Publicatiedatum: 01-12-2010
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-1110-z

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