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Journal of Autism and Developmental Disorders

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15-06-2022 | Original Paper

Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism

Auteurs: Livia Nascimento Rabelo, José Pablo Gonçalves Queiroz, Carla Cristina Miranda Castro, Sayonara Pereira Silva, Laura Damasceno Campos, Larissa Camila Silva, Ezequiel Batista Nascimento, Veronica Martínez-Cerdeño, Felipe Porto Fiuza

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2023

Abstract

Autism spectrum disorder (ASD) is manifested by abnormal cell numbers and patches of gene expression disruption in higher-order brain regions. Here, we investigated whether layer-specific changes in glia/neuron ratios (GNR) characterize patches in the dorsolateral prefrontal cortex (DL-PFC) of children with ASD. We analyzed high-resolution digital images of postmortem human brains from 11 ASD and 11 non-ASD children obtained from the Autism Study of the Allen Human Brain Atlas. We found the GNR is overall reduced in the ASD DL-PFC. Moreover, layers II-III belonging to patches presented a lower GNR in comparison with layers V-VI. We here provide a new insight into how brain cells are arranged within patches that contributes to elucidate how neurodevelopmental programs are altered in ASD.

vorige artikel Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis

volgende artikel Theory of Mind Predicts Social Interaction in Children with Autism Spectrum Disorder: A Two-Year Follow-Up Study

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Titel: Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism
Auteurs: Livia Nascimento Rabelo
José Pablo Gonçalves Queiroz
Carla Cristina Miranda Castro
Sayonara Pereira Silva
Laura Damasceno Campos
Larissa Camila Silva
Ezequiel Batista Nascimento
Veronica Martínez-Cerdeño
Felipe Porto Fiuza
Publicatiedatum: 15-06-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05626-8

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