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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2011 | Original paper

Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review

Auteurs: Sanjiv B. Amin, Tristram Smith, Hongyue Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2011

Abstract

Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. Thirteen studies were included in a meta-analysis. Most used retrospective matched case–control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22–1.67, random effect model). This association was not found in preterms (OR 0.7, 95% CI 0.38–1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms.

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Titel: Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review
Auteurs: Sanjiv B. Amin
Tristram Smith
Hongyue Wang
Publicatiedatum: 01-11-2011
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-1169-6

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