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Brainstem auditory evoked potential study in children with autistic disorder

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Abstract

Brainstem auditory evoked potentials were compared in 109 children with infantile autism, 38 with autistic condition, 19 with mental retardation, and 20 normal children. Children with infantile autism or autistic condition had significantly longer brainstem transmission time than normal (p<.001). Autistic features, rather than age, sex, or lower mentality, correlated with brainstem transmission time (p<.0001). The autistic characteristics may be related to dysfunction of the brainstem which affects the processing of the sensory input through the auditory pathway. The brainstem lesion may be part of a generalized process of neurological damage that accounts for the deviant language, cognitive, and social development in the spectrum of autistic disorder.

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References

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., rev., pp. 33–39). Washington, DC: Author.

    Google Scholar 

  • Courchesne, E., Kilman, B. A., Galambos, R., & Lincoln, A. J. (1984). Autism: Processing of novel auditory information assessed by event related brain potentials.Electroencephalography and Clinical Neurology, 59, 238–248.

    Google Scholar 

  • Courchesne, E., Courchesne, R. Y., Hicks, G., & Lincoln, A. J. (1985). Functioning of the brainstem auditory pathway in non-retarded autistic individuals.Electroencephalography and Clinical Neurophysiology, 61, 491–501.

    PubMed  Google Scholar 

  • Courchesne, E., Hesselink, J. R., Jernigan, T. L., & Yeung-Courchesne, R. (1987). Abnormal neuroanatomy in a nonretarded person with autism. Unusual findings in magnetic resonance imaging.Archives of Neurology, 44, 335–340.

    PubMed  Google Scholar 

  • Courchesne, E., Lincoln, A. J., Kilman, B. A., & Galambos, R. (1985). Event-related brain potential correlates of the processing of novel visual and auditory information in autism.Journal of Autism and Developmental Disorders, 15, 55–76.

    PubMed  Google Scholar 

  • Courchesne, E., Yeung-Courchesne, R., Press, G. A., Hesselink, J. R., & Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in autism.New England Journal of Medicine, 318, 1349–1354.

    PubMed  Google Scholar 

  • Doll, E. A. (1965).Vineland Social Maturity Scale Manual (3rd Ed.). American Guidance Service.

  • Ferri, R., Bergonzi, P., Colognola, R. M., Musumeci, S. A., Sanfilippo, S., Tomassetti, P., Viglianesi, A., & Gigli, G. L. (1986). Brainstem auditory evoked potentials in subjects with mental retardation and different karyotypes. In V. Gallai (Ed.),Maturation of the CNS and evoked potentials (369–374). Amsterdam, The Netherlands: Elsevier.

    Google Scholar 

  • Gillberg, C., Rosenthal, U., & Johansson, E. (1983). Auditory brainstem responses in childhood psychosis.Journal of Autism and Developmental Disorders, 13, 181–195.

    PubMed  Google Scholar 

  • Griffiths, R. (1970).The abilities of young children. London: Children Research Centre.

    Google Scholar 

  • Hecox, K. (1982). Pediatric applications of the brainstem auditory evoked response. In G. A. Chiarenza & D. Papakostopoulos (Eds.),Proceedings of the International Conference on Clinical Application of Cerebral Evoked Potentials in Pediatric Neurology (pp. 397–414). Amsterdam, The Netherlands: Excerpta Medica.

    Google Scholar 

  • Hecox, K., & Galambos, R. (1974). Brainstem auditory evoked responses in human infants and adults.Archives of Otolaryngology, 99, 30–33.

    PubMed  Google Scholar 

  • Martineau, J., Garreau, B., & Lelord, G. (1987). Auditory evoked responses and their modifications during conditioning paradigm in autistic children.Journal of Autism and Developmental Disorders, 17, 525–539.

    PubMed  Google Scholar 

  • Moller, R., & Jannetta, P. J. (1985). Neural generators of the auditory brainstem response. In J. T. Jacobson (Ed.),The auditory brainstem response (Chap. 2, pp. 13–32). London: Taylor & Francis.

    Google Scholar 

  • Novick, B., Kurtzberg, A., & Vaughan, H. G., Jr. (1979). An electrophysiologic indication of defective information storage in childhood autism.Psychiatry Research, 3, 107–114.

    Google Scholar 

  • O'Donoran, C. A., Beagley, H. A., & Shaw, H. (1980). Latency of brainstem responses in children.British Journal of Audiology, 14, 23–29.

    PubMed  Google Scholar 

  • Ornitz, E. M., & Walter, D. O. (1975). The effect of sound pressure waveform on human brainstem auditory evoked responses.Brain Research, 92, 490–498.

    PubMed  Google Scholar 

  • Ornitz, E. M., Mo, A., & Olson, S. T. (1980). Influence of click sound pressure direction on brainstem responses in children.Audiology, 19, 245–254.

    PubMed  Google Scholar 

  • Ritvo, E. R., Creel, D., Realmuto, G., Crandall, A. S., Freeman, B. J., Bateman, J. B., Barr, R., Pingree, C., Coleman, M., & Purple, R. (1988). Electroretinograms in autism: a pilot study of b-wave amplitudes.American Journal of Psychiatry, 145, 229–232.

    PubMed  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Scheilbel, A. B., Duong, T., Robinson, H., Guthrie, D., & Ritvo, A. (1986). Lower purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report.American Journal of Psychiatry, 143, 862–866.

    PubMed  Google Scholar 

  • Rosenblum, S. M., Arick, J. R., Krug, D. A., Stubbs, E. G., Young, N. B., & Pelson, R. O. (1980). Auditory brainstem evoked responses in autistic children.Journal of Autism and Developmental Disorders, 10, 215–225.

    PubMed  Google Scholar 

  • Rutter, M. (1978). Diagnosis and definition. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatments. New York: Plenum Press.

    Google Scholar 

  • Rutter, M. (1985). Infantile autism and other pervasive developmental disorders. In M. Rutter & L. Hersov (Eds.),Child and adolescent psychiatry (2nd ed., pp. 545–566). London: Blackwell.

    Google Scholar 

  • Skoff, B. F., Mirsky, A. F., & Turner, D. (1980). Prolonged brainstem transmission time in autism.Psychiatric Research, 2, 157–166.

    Google Scholar 

  • Sohmer, H., & Student, M. (1978). Auditory nerve and brainstem evoked response in normal, autistic, minimal brain dysfunction and psychomotor retarded children.Electroencephalography and Clinical Neurophysiology, 44, 380–388.

    PubMed  Google Scholar 

  • Stockard, J. J., Stockard, J. E., & Sharbrough, F. W. (1978). Non-pathologic factors influencing brainstem auditory evoked potentials.American Journal of EEG Technology, 18, 117–209.

    Google Scholar 

  • Stockard, J. J., Stockard, J. E., & Sharbrough, F. W. (1980). Brainstem auditory evoked potentials in neurology: Methodology, interpretation, clinical application. In M. J. Aminoff (Ed.),Electrodiagnosis in clinical neurology (pp. 383–384). London: Churchill Livingstone.

    Google Scholar 

  • Student, M., & Sohmer, H. (1978). Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits.Journal of Autism and Childhood Schizophrenia, 8, 13–20.

    PubMed  Google Scholar 

  • Tanguay, P. E., & Edwards, R. (1982). Electrophysiological studies of autism: The whisper of the bang.Journal of Autism and Developmental Disorders, 12, 177–184.

    PubMed  Google Scholar 

  • Tanguay, P. E., Edwards, R. M., Buchwald, J., Schwafel, J., & Allen, V. (1982). Auditory brainstem responses in autistic children.Archives of General Psychiatry, 39, 174–180.

    PubMed  Google Scholar 

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We thank R. Ko and F. Pun for their scretarial assistance.

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Wong, V., Wong, S.N. Brainstem auditory evoked potential study in children with autistic disorder. J Autism Dev Disord 21, 329–340 (1991). https://doi.org/10.1007/BF02207329

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