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01-06-2012 | Original Paper

Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors?

Auteurs: Maryam M. Abdullah, Agnes R. Ly, Wendy A. Goldberg, K. Alison Clarke-Stewart, John V. Dudgeon, Christopher G. Mull, Tony J. Chan, Erin E. Kent, Andrew Z. Mason, Jonathon E. Ericson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2012

Abstract

To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB.

vorige artikel Is Long-Term Prognosis for Pervasive Developmental Disorder Not Otherwise Specified Different from Prognosis for Autistic Disorder? Findings from a 30-Year Follow-Up Study

volgende artikel Visual Attention and Autistic Behavior in Infants with Fragile X Syndrome

Adams, J. B., Romdalvik, J., Ramanujam, V. M. S., & Legator, M. S. (2007). Mercury, lead, and zinc in baby teeth of children with autism versus controls. Journal of Toxicology and Environmental Health. Part A, 70(12), 1046–1051. doi: 10.1080/15287390601172080. PubMedCrossRef

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed. text revision). Washington, DC: Author.

Ash, M. M., & Nelson, S. J. (2003). Wheeler’s dental anatomy, physiology and occlusion (8th ed.). St Louis: Elsevier.

Bass, D. A., Hickock, D., Quig, D., & Urek, K. (2001). Trace element analysis in hair: Factors determining accuracy, precision, and reliability. Alternative Medicine Review, 6, 472–481. PubMed

Bouchard, M., Laforest, F., Vandelac, L., Bellinger, D., & Mergler, D. (2007). Hair manganese and hyperactive behaviors: Pilot study of school-age children exposed through tap water. Environmental Health Perspectives, 115(1), 122–127. doi: 10.1289/ehp.9504. PubMedCrossRef

Braun, J. M., Kahn, R. S., Froehlich, T., Auinger, P., & Lanphear, B. P. (2006). Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspectives, 114(12), 1904–1909. doi: 10.1289/ehp.9478. PubMed

Cohen, J. (1988). Statistical power for the behavioral sciences. Hillsdale, NJ: Erlbaum.

Costa, L. G., Aschner, M., Vitalone, A., Syversen, T., & Soldin, O. P. (2004). Developmental neuropathology of environmental agents. Annual Review of Pharmacology and Toxicology, 44(1), 87–110. doi: 10.1146/annurev.pharmtox.44.101802.121424. PubMedCrossRef

Davidson, P. W., Myers, G. J., Cox, C., Axtell, C., Shamlaye, C., Sloane-Reeves, J., et al. (1998). Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: Outcomes at 66 months of age in the Seychelles Child Development Study. Journal of the American Medical Association, 280(8), 701–707. doi: 10.1001/jama.280.8.701. PubMedCrossRef

DeSoto, M. C., & Hitlan, R. T. (2010). Sorting out the spinning of autism: Heavy metals and the question of incidence. Acta Neurobiologiae Experimentalis, 70, 165–176. PubMedCrossRef

Dietrich, K. N., Ris, M. D., Succop, P. A., Berger, O. G., & Bornschein, R. L. (2001). Early exposure to lead and juvenile delinquency. Neurotoxicology and Teratology, 23(6), 511–518. doi: 10.1016/S0892-0362(01)00184-2. PubMedCrossRef

Ericson, J. E., Crinella, F. M., Clarke-Stewart, K. A., Allhusen, V. D., Chan, T., & Robertson, R. T. (2007). Prenatal manganese levels linked to childhood behavioral disinhibition. Neurotoxicology and Teratology, 29(2), 181–187. doi: 10.1016/j.ntt.2006.09.020. PubMedCrossRef

Farmer, J. G., MacKenzie, A. B., & Moody, G. H. (2006). Human teeth as historical biomonitors of environmental and dietary lead: Some lessons from isotopic studies of 19th and 20th century archival material. Environmental Geochemistry and Health, 28, 421–430. doi: 10.1007/s10653-006-9041-5. PubMedCrossRef

Fergusson, J. E., & Purchase, N. G. (1987). The analysis and levels of lead in human teeth: A review. Environmental Pollution, 46, 11–44. doi: 10.1016/0269-7491(87)90143-6. PubMedCrossRef

Fido, A., & Al-Saad, S. (2005). Toxic trace elements in the hair of children with autism. Autism, 9(3), 290–298. doi: 10.1177/1362361305053255. PubMedCrossRef

Fido, A., Dashti, H., & Al-Saad, S. (2002). Biological correlates of childhood autism: Trace elements. Trace Elements and Electrolytes, 19, 205–208.

Froehlich, T. E., Lanphear, B. P., Auinger, P., Hornung, R., Epstein, J. N., Braun, J., et al. (2009). Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder. Pediatrics, 124, e1054–e1063. doi: 10.1542/peds.2009-0738. PubMedCrossRef

Gentile, P. S., Trentalange, M. J., Zamichek, W., & Coleman, M. (1983). Trace elements in the hair of autistic and control children. Journal of Autism and Developmental Disorders, 13(2), 205–206. doi: 10.1007/BF01531820. PubMedCrossRef

Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33, 607–616, doi: 10.1023/B:JADD.0000005998.47370.ef. PubMedCrossRef

Grafodatskaya, D., Chung, B., Szatmari, P., & Weksburg, R. (2010). Autism spectrum disorders and epigenetics. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 794–809. doi: 10.1016/j.jaac.2010.05.005. PubMedCrossRef

Grandjean, P., & Landrigan, P. (2006). Developmental neurotoxicity of industrial chemicals. The Lancet, 368(9553), 2167–2178. doi: 16/S0140-6736(06)69665-7. CrossRef

Heron, J., Golding, J., & the ALSPAC Study Team. (2004). Thimerosal exposure in infants and developmental disorders: A prospective cohort study in the United Kingdom does not support a causal association. Pediatrics, 114, 577–583. doi: 10.1542/peds.2003-1176-L. PubMedCrossRef

Hertz-Picciotto, I., Green, P. G., Delwiche, L., Hansen, R., Walker, C., & Pessah, I. N. (2010). Blood mercury concentrations in CHARGE Study children with and without autism. Environmental Health Perspectives, 118(1), 161–166. doi: 10.1289/ehp.0900736. PubMed

Honda, H., Shimizu, Y., & Rutter, M. (2005). No effect of MMR withdrawal on the incidence of autism: A total population study. Journal of Child Psychology and Psychiatry, 46, 572–579. doi: 10.1111/j.1469-7610.2005.01425.x. PubMedCrossRef

Kalkbrenner, A. E., Daniels, J. L., Chen, J., Poole, C., Emch, M., & Morrissey, J. (2010). Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology, 21, 631–641. doi: 10.1097/EDE.0b013e3181e65d76. PubMedCrossRef

Kang, D., Amarasiriwardena, D., & Goodman, A. H. (2004). Application of laser ablation–inductively coupled plasma-mass spectrometry (LA–ICP–MS) to investigate trace metal spatial distributions in human tooth enamel and dentine growth layers and pulp. Analytical and Bioanalytical Chemistry, 378, 1608–1615. doi: 10.1007/s00216-004-2504-6. PubMedCrossRef

Kogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., et al. (2009). Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics, 124, 1395–1403. doi: 10.1542/peds.2009-1522. PubMedCrossRef

Lakshmi Priya, M. D., & Geetha, A. (2010) Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biological Trace Element Research. doi: 10.1007/s12011-010-8766-2.

Landrigan, P. J. (2010). What causes autism? Exploring the environmental contribution. Current Opinion in Pediatrics, 22, 219–225. doi: 10.1097/MOP.0b013e328336eb9a. PubMedCrossRef

Landrigan, P. J., Trasande, L., Thorpe, L. E., Gwynn, C., Lioy, P. J., D’Alton, M. E., et al. (2006). The National Children’s Study: A 21-year prospective study of 100,000 American children. Pediatrics, 118(5), 2173–2186. doi: 10.1542/peds.2006-0360. PubMedCrossRef

Lewandowski, T. A. (2011). Evolving understanding of the relationship between mercury exposure and autism. In L. I. Simeonov, M. V. Kochubovski, & B. G. Simeonova (Eds.), Environmental heavy metal pollution and effects on child mental development (Vol. 1, pp. 65–84). Dordrecht: Springer Netherlands. Retrieved from http://www.springerlink.com/content/l4n65m6600547417/.

Ljung, K., & Vahter, M. (2007). Time to re-evaluate the guideline value for manganese in drinking water? Environmental Health Perspectives, 115, 1533–1538. doi: 10.1289/ehp.10316. PubMedCrossRef

Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule. Los Angeles, CA: Western Psychological Services.

Madsen, K. M., Hviid, A., Vestergaard, M., Schendel, D., Wohlfahrt, J., Thorsen, P., et al. (2002). A population-based study of measles, mumps, and rubella vaccination and autism. New England Journal of Medicine, 347, 1477–1482. PubMedCrossRef

Menezes-Filho, J. A., de Novaes, C. O., Moreira, J. C., Sarcinelli, P. N., & Mergler, D. (2011). Elevated manganese and cognitive performance in school-aged children and their mothers. Environmental Research, 111, 156–163. doi: 16/j.envres.2010.09.006. PubMedCrossRef

Nanci, A. (2008). Ten Cate’s oral histology: Development, structure, and function (7th ed.). St. Louis: Mosby.

Neff, H., & Dudgeon, J. V. (2006). LA-ICP-MS analysis of ceramics and ceramic raw materials from the Gila River Indian community, Arizona, (Research Report: Institute for Integrated Research in Materials, Environments, and Society). Long Beach, CA: California State University, Long Beach.

NICHD Early Child Care Research Network. (2005). Child care and child development: Results from the NICHD Study of Early Child Care and Youth Development. New York: Guilford.

Nigg, J. T., Knottnerus, G. M., Martel, M. M., Nikolas, M., Cavanagh, K., Karmaus, W., et al. (2008). Low blood lead levels associated with clinically diagnosed attention-deficit/hyperactivity disorder and mediated by weak cognitive control. Biological Psychiatry, 63(3), 325–331. doi: 10.1016/j.biopsych.2007.07.013. PubMedCrossRef

Palmer, R. F., Blanchard, S., Stein, Z., Mandell, D., & Miller, C. (2006). Environmental mercury release, special education rates, and autism disorder: An ecological study of Texas. Health & Place, 12, 203–209. doi: 16/j.healthplace.2004.11.005. CrossRef

Palmer, R. F., Blanchard, S., & Wood, R. (2009). Proximity to point sources of environmental mercury release as a predictor of autism prevalence. Health & Place, 15, 18–24. doi: 16/j.healthplace.2008.02.001. CrossRef

Pelham, W. E., Gnagy, E., Greenslade, K., & Milich, R. (1992). Teacher ratings of DSM-III-R symptoms for the disruptive behavior disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 210–218. PubMedCrossRef

Pocock, S. J., Smith, M., & Baghurst, P. (1994). Environmental lead and children’s intelligence: A systematic review of the epidemiological evidence. British Medical Journal, 309, 1189–1197. PubMedCrossRef

Ris, M. D., Dietrich, K. N., Succop, P. A., Berger, O. G., & Bornschein, R. L. (2004). Early exposure to lead and neuropsychological outcome in adolescence. Journal of the International Neuropsychological Society, 10, 261–270. doi: 10.1017/S1355617704102154. PubMedCrossRef

Rodier, P. M. (1995). Developing brain as a target of toxicity. Environmental Health Perspectives, 103(6), 73–76. PubMedCrossRef

Rutter, M., Le Couteur, A., & Lord, C. (2003). ADI-R: The autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services.

Soden, S. E., Lowry, J. A., Garrison, C. B., & Wasserman, G. S. (2007). 24-hour provoked urine excretion test for heavy metals in children with autism and typically developing controls, a pilot study. Clinical Toxicology, 45, 476–481. doi: 10.1080/15563650701338195. PubMedCrossRef

Speakman, R. J., & Neff, H. (2005). Laser ablation ICP-MS in archaeological research. Albuquerque, NM: University of New Mexico Press.

Takser, L., Mergler, D., Hellier, G., Sahuquillo, J., & Huel, G. (2003). Manganese, monoamine metabolite levels at birth, and child psychomotor development. Neurotoxicology, 24(4–5), 667–674. doi: 10.1016/S0161-813X(03)00058-5. PubMedCrossRef

Tvinnereim, H. M., Eide, R., Fosse, G., Wesenberg, G. R., Szøke, J., & Banoczy, J. (1996). Trace elements in primary teeth from six areas in Hungary. International Journal of Environmental Studies, 50, 267–275. doi: 10.1016/S0048-9697(00)00436-8. CrossRef

Uryu, T., Yoshinaga, J., Yanagisawa, Y., Endo, M., & Takahashi, J. (2003). Analysis of lead in tooth enamel by laser ablation-inductively coupled plasma-mass spectrometry. Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry, 19(10), 1413–1416. CrossRef

Wang, H. L., Chen, X. T., Yang, B., Ma, F. L., Wang, S., Tang, M. L., et al. (2008). Case–control study of blood lead levels and attention deficit hyperactivity disorder in chinese children. Environmental Health Perspectives, 116(10), 1401–1406. doi: 10.1289/ehp.11400. PubMedCrossRef

Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Levy, D., Factor-Litvak, P., et al. (2006). Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh. Environmental Health Perspectives, 114, 124–129. doi: 10.1289/ehp.8030. PubMed

Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., & Grether, J. K. (2006). Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environmental Health Perspectives, 114, 1438–1444. PubMedCrossRef

Wright, R. O., Amarasiriwardena, C., Woolf, A. D., Jim, R., & Bellinger, D. C. (2006). Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. Neurotoxicology, 27, 210–216. doi: 16/j.neuro.2005.10.001. PubMedCrossRef

Titel: Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors?
Auteurs: Maryam M. Abdullah
Agnes R. Ly
Wendy A. Goldberg
K. Alison Clarke-Stewart
John V. Dudgeon
Christopher G. Mull
Tony J. Chan
Erin E. Kent
Andrew Z. Mason
Jonathon E. Ericson
Publicatiedatum: 01-06-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1318-6

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