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Analysis of Lead in Tooth Enamel by Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry

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Abstract

Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) was used to determine the Pb/Ca ratios in the enamel of deciduous incisors, a biomarker of in utero Pb exposure, using pelletized bone certified reference materials (CRMs) as calibrants. The detection limit for Pb by LA-ICP-MS was 11 µg kg–1 demonstrating an adequate sensitivity for Pb in the teeth of unexposed individuals (0.1–10 mg kg–1). The precision for the Pb/Ca ratios in NIST SRM 1486 Bone Meal was 3.4%. The correlation between Pb/Ca ratios obtained by LA-ICP-MS and those obtained by a digestion method was highly significant. We found one point calibration by a CRM was applicable for the quantification of Pb in tooth enamel. This method will be valuable for the assessment of in utero Pb exposure levels.

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Correspondence to Jun Yoshinaga.

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Uryu, T., Yoshinaga, J., Yanagisawa, Y. et al. Analysis of Lead in Tooth Enamel by Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry. ANAL. SCI. 19, 1413–1416 (2003). https://doi.org/10.2116/analsci.19.1413

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  • DOI: https://doi.org/10.2116/analsci.19.1413

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