TODO: Skip to main content
Top
Gepubliceerd in:

18-10-2016

Health-related quality of life associated with systemic corticosteroids

Auteurs: Patrick W. Sullivan, Vahram H. Ghushchyan, Gary Globe, Brandon Sucher

Gepubliceerd in: Quality of Life Research | Uitgave 4/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Background

Systemic corticosteroids (SCS) are commonly used but are associated with adverse effects. Given their prevalent use, the potential impact of SCS use on health-related quality of life (HRQoL) is important to characterize.

Objective

To assess the HRQoL of patients taking SCS.

Methods

The 2000–2003 Medical Expenditure Panel Survey was used to examine EQ-5D and SF-6D scores associated with SCS use in adults. The study sample was restricted to those with a condition for which SCS are prescribed. SCS use was categorized into three levels: none; 1–3; and ≥4 prescriptions per year. HRQoL scores were regressed on SCS use (1–3 or ≥4 annual prescriptions) controlling for age, gender, race, ethnicity, education, income category, geographic region, number of ER visits, number of outpatient visits, total number of chronic conditions (for which SCS are not used) and conditions for which SCS are clinically indicated.

Results

There were 54,856 individuals with no SCS exposure, 2245 with 1–3 and 624 with ≥4 annual SCS prescriptions. In adjusted analyses, use of ≥4 annual SCS prescriptions appeared to be associated with significantly lower EQ-5D (US), EQ-5D (UK), SF-6D and EQ-5D VAS scores compared to no exposure: −0.032, −0.047, −0.036, and −7.58.

Conclusion

While SCS are efficacious and widely used for numerous conditions, results suggest that their use may be associated with a substantial deleterious impact on HRQoL. This potential negative effect should be considered in balance with the cost and efficacy of comparable treatments.
Bijlagen
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Literatuur
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Metagegevens
Titel
Health-related quality of life associated with systemic corticosteroids
Auteurs
Patrick W. Sullivan
Vahram H. Ghushchyan
Gary Globe
Brandon Sucher
Publicatiedatum
18-10-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1435-y