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Gepubliceerd in: Quality of Life Research 3/2015

01-03-2015

A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales

Auteurs: Michael E. Hyland, Ben Whalley, Rupert C. Jones, Matthew Masoli

Gepubliceerd in: Quality of Life Research | Uitgave 3/2015

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Abstract

Background

People with severe asthma experience significant respiratory symptoms and suffer adverse effects of oral corticosteroids (OCS), including disturbed mood and physical symptoms. OCS impacts on health-related quality of life (HRQoL) have not been quantified. Asthma HRQoL scales are valid as outcome measures for patients requiring OCS only if they assess the deficits imposed by OCS.

Aims

The aim of this study was to compare the burden of disease and treatment in patients with severe asthma with items in eight asthma-specific HRQoL scales.

Methods

Twenty-three patients with severe asthma recruited from a severe asthma clinic were interviewed about the impact of their respiratory symptoms and the burden of their treatment. The domains from a thematic analysis of these interviews were compared with the items of eight asthma-specific HRQoL scales.

Results

In addition to the burden caused by symptoms, ten domains of OCS impact on HRQoL were identified: depression, irritability, sleep, hunger, weight, skin, gastric, pain, disease anxiety, and medication anxiety. Some patients experienced substantial HRQoL deficits attributed to OCS. Although all HRQoL scales include some OCS-relevant items, all eight scales fail to adequately assess the several types of burden experienced by some patients while on OCS.

Conclusion

The burden of OCS in severe asthma is neglected in policy and practice because it is not assessed in outcome studies. Existing asthma HRQoL scales provide an overly positive estimation of HRQoL in patients with frequent exposure to OCS and underestimate the benefit of interventions that reduce OCS exposure. Changes to existing measurement procedures are needed.
Literatuur
1.
go back to reference Jones, P. W. (1995). Quality of life measurement in asthma. European Respiratory Journal, 8, 885–887.PubMed Jones, P. W. (1995). Quality of life measurement in asthma. European Respiratory Journal, 8, 885–887.PubMed
3.
go back to reference Hyland, M. E. (1992). Selection of items and avoidance of bias in quality of life scales. Pharmacoeconomics, 1, 182–190.CrossRefPubMed Hyland, M. E. (1992). Selection of items and avoidance of bias in quality of life scales. Pharmacoeconomics, 1, 182–190.CrossRefPubMed
4.
go back to reference Gamble, J., Fitzsimons, D., Lynes, D., & Heaney, L. G. (2007). Difficult asthma: People’s perspectives on taking corticosteroid therapy. Journal of Clinical Nursing, 16, 59–67.CrossRefPubMed Gamble, J., Fitzsimons, D., Lynes, D., & Heaney, L. G. (2007). Difficult asthma: People’s perspectives on taking corticosteroid therapy. Journal of Clinical Nursing, 16, 59–67.CrossRefPubMed
5.
go back to reference Stevenson, F. A., Wallace, G., Rivers, P., & Gerrett, D. (1999). It’s the best of two evils’: A study of patients’ perceived information needs about oral steroids for asthma. Health Expectations, 2, 185–194.CrossRefPubMed Stevenson, F. A., Wallace, G., Rivers, P., & Gerrett, D. (1999). It’s the best of two evils’: A study of patients’ perceived information needs about oral steroids for asthma. Health Expectations, 2, 185–194.CrossRefPubMed
6.
go back to reference Ethgen, O., de Lemos, Esteves. F., Bruyere, O., & Reginster, J. Y. (2013). What do we know about the safety of corticosteroids in rheumatoid arthritis? Current Medical Research & Opinion, 29, 1147–1160.CrossRef Ethgen, O., de Lemos, Esteves. F., Bruyere, O., & Reginster, J. Y. (2013). What do we know about the safety of corticosteroids in rheumatoid arthritis? Current Medical Research & Opinion, 29, 1147–1160.CrossRef
7.
go back to reference Fardet, L., Flahault, A., Kettaneh, A., et al. (2007). Corticosteroid-induced clinical adverse events: Frequency, risk factors and patient’s opinion. British Journal of Dermatology, 157, 142–148.CrossRefPubMed Fardet, L., Flahault, A., Kettaneh, A., et al. (2007). Corticosteroid-induced clinical adverse events: Frequency, risk factors and patient’s opinion. British Journal of Dermatology, 157, 142–148.CrossRefPubMed
8.
go back to reference Brown, E. S., & Chandler, P. A. (2001). Mood and cognitive changes during systemic corticosteroid therapy. Primary Care Companion to the Journal of Clinical Psychiatry, 3, 17–21.CrossRefPubMedCentralPubMed Brown, E. S., & Chandler, P. A. (2001). Mood and cognitive changes during systemic corticosteroid therapy. Primary Care Companion to the Journal of Clinical Psychiatry, 3, 17–21.CrossRefPubMedCentralPubMed
9.
go back to reference Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3, 77–101.CrossRef Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3, 77–101.CrossRef
10.
go back to reference Reddel, H. K., Taylor, D. R., & Bateman, E. D. (2009). Official American Thoracic Society/European Respiratory Society Statement: Asthma control and exacerbations standardizing endpoints for clinical asthma trials and clinical practice. American Journal of Respiratory and Critical Care Medicine, 180, 59–99.CrossRefPubMed Reddel, H. K., Taylor, D. R., & Bateman, E. D. (2009). Official American Thoracic Society/European Respiratory Society Statement: Asthma control and exacerbations standardizing endpoints for clinical asthma trials and clinical practice. American Journal of Respiratory and Critical Care Medicine, 180, 59–99.CrossRefPubMed
11.
go back to reference Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992). Evaluation of impairment of health related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax, 47, 76–83.CrossRefPubMedCentralPubMed Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992). Evaluation of impairment of health related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax, 47, 76–83.CrossRefPubMedCentralPubMed
12.
go back to reference Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R. (1999). Development and validation of the Mini Asthma Quality of Life Questionnaire. European Respiratory Journal, 14, 32–38.CrossRefPubMed Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R. (1999). Development and validation of the Mini Asthma Quality of Life Questionnaire. European Respiratory Journal, 14, 32–38.CrossRefPubMed
13.
go back to reference Hyland, M. E., Finnis, S., & Irvine, S. H. (1991). A scale for assessing quality of life in adult asthma sufferers. Journal of Psychosomatic Research, 35, 99–110.CrossRefPubMed Hyland, M. E., Finnis, S., & Irvine, S. H. (1991). A scale for assessing quality of life in adult asthma sufferers. Journal of Psychosomatic Research, 35, 99–110.CrossRefPubMed
14.
go back to reference Jones, P. W., Quirk, F. H., Baveystock, C. M., & Littlejohns, P. (1992). A self-complete measure of health status for chronic airflow limitation. The American Review of Respiratory Disease, 145, 1321–1327.CrossRefPubMed Jones, P. W., Quirk, F. H., Baveystock, C. M., & Littlejohns, P. (1992). A self-complete measure of health status for chronic airflow limitation. The American Review of Respiratory Disease, 145, 1321–1327.CrossRefPubMed
15.
go back to reference Marks, G. B., Dunn, S. M., & Woolcock, A. J. (1992). A scale for the measurement of quality of life in adults with asthma. Journal of Clinical Epidemiology, 45, 461–472.CrossRefPubMed Marks, G. B., Dunn, S. M., & Woolcock, A. J. (1992). A scale for the measurement of quality of life in adults with asthma. Journal of Clinical Epidemiology, 45, 461–472.CrossRefPubMed
16.
go back to reference Barley, E. A., Quirk, F. H., & Jones, P. W. (1998). Asthma health status measurement in clinical practice: Validity of a new short and simple instrument. Respiratory Medicine, 92, 1207–1214.CrossRefPubMed Barley, E. A., Quirk, F. H., & Jones, P. W. (1998). Asthma health status measurement in clinical practice: Validity of a new short and simple instrument. Respiratory Medicine, 92, 1207–1214.CrossRefPubMed
17.
go back to reference Hyland, M. E., Ley, A., Fisher, D. W., & Woodward, V. (1995). Measurement of psychological distress in asthma and asthma management programmes. British Journal of Clinical Psychology, 34, 601–611.CrossRefPubMed Hyland, M. E., Ley, A., Fisher, D. W., & Woodward, V. (1995). Measurement of psychological distress in asthma and asthma management programmes. British Journal of Clinical Psychology, 34, 601–611.CrossRefPubMed
18.
go back to reference Castro, M., King, T. S., Kunselman, S. J., Cabana, M. D., Denlinger, L., Holguin, F., et al. (2014). Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: The VIDA randomized clinical trial. Journal of the American Medical Association, 311, 2083–2091. Castro, M., King, T. S., Kunselman, S. J., Cabana, M. D., Denlinger, L., Holguin, F., et al. (2014). Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: The VIDA randomized clinical trial. Journal of the American Medical Association, 311, 2083–2091.
19.
go back to reference Parry, G. D., Cooper, C. L., Moore, J. M., et al. (2012). Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial. Respiratory Medicine, 106, 802–810.CrossRefPubMed Parry, G. D., Cooper, C. L., Moore, J. M., et al. (2012). Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial. Respiratory Medicine, 106, 802–810.CrossRefPubMed
20.
go back to reference Eberhart, N. K., Sherbourne, C. D., Edelen, M. O., Stucky, B. D., Sin, N. L., & Lara, M. (2013). Development of a measure of asthma-specific quality of life among adults. Quality of Life Research, 23, 837–848. Eberhart, N. K., Sherbourne, C. D., Edelen, M. O., Stucky, B. D., Sin, N. L., & Lara, M. (2013). Development of a measure of asthma-specific quality of life among adults. Quality of Life Research, 23, 837–848.
21.
go back to reference Gamble, J., Stevenson, M., McClean, E., & Heaney, L. G. (2009). The prevalence of nonadherence in difficult asthma. American Journal of Respiratory and Critical Care Medicine, 180, 817–822.CrossRefPubMed Gamble, J., Stevenson, M., McClean, E., & Heaney, L. G. (2009). The prevalence of nonadherence in difficult asthma. American Journal of Respiratory and Critical Care Medicine, 180, 817–822.CrossRefPubMed
22.
go back to reference Meeus, M., & Nijs, J. (2007). Central sensitization: A biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clinical Rheumatology, 26, 465–473.CrossRefPubMedCentralPubMed Meeus, M., & Nijs, J. (2007). Central sensitization: A biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clinical Rheumatology, 26, 465–473.CrossRefPubMedCentralPubMed
23.
go back to reference Apfelbacher, C. J., Hankins, M., Stenner, P., Frew, A. J., & Smith, H. E. (2011). Measuring asthma-specific quality of life: Structured review. Allergy, 2011(66), 439–457.CrossRef Apfelbacher, C. J., Hankins, M., Stenner, P., Frew, A. J., & Smith, H. E. (2011). Measuring asthma-specific quality of life: Structured review. Allergy, 2011(66), 439–457.CrossRef
24.
go back to reference Apfelbacher, C., Weiß, M., Saur, J., Smith, H., & Loerbroks, A. (2012). Patients’ views on asthma-specific quality of life questionnaires: Qualitative interview study in Germany. Journal of Asthma, 2012(49), 875–883.CrossRef Apfelbacher, C., Weiß, M., Saur, J., Smith, H., & Loerbroks, A. (2012). Patients’ views on asthma-specific quality of life questionnaires: Qualitative interview study in Germany. Journal of Asthma, 2012(49), 875–883.CrossRef
25.
go back to reference Brown, H. M. (1958). Treatment of chronic asthma with prednisolone. Lancet, 272, 1245–1247.CrossRef Brown, H. M. (1958). Treatment of chronic asthma with prednisolone. Lancet, 272, 1245–1247.CrossRef
26.
go back to reference Hyland, M. E., Coward, G., Upchurch, F., & Jones, K. P. (1991). Asthma specific quality of life scale in a study of salmeterol hydroxynaphthoate. The British Journal of General Practice, 41, 214.PubMedCentralPubMed Hyland, M. E., Coward, G., Upchurch, F., & Jones, K. P. (1991). Asthma specific quality of life scale in a study of salmeterol hydroxynaphthoate. The British Journal of General Practice, 41, 214.PubMedCentralPubMed
27.
go back to reference Milgrom, H., Fick, R. B., Su, J. Q., Reimann, J. D., Bush, R. K., Watrous, M. L., et al. (1999). Treatment of allergic asthma with monoclonal anti-IgE antibody. New England Journal of Medicine, 341, 1966–1973.CrossRefPubMed Milgrom, H., Fick, R. B., Su, J. Q., Reimann, J. D., Bush, R. K., Watrous, M. L., et al. (1999). Treatment of allergic asthma with monoclonal anti-IgE antibody. New England Journal of Medicine, 341, 1966–1973.CrossRefPubMed
28.
go back to reference Pakhale, S., Wood-Dauphinee, S., Spahija, A., Collet, J. P., Maltais, F., Bernard, S., et al. (2012). Respiratory Network of the FRSQ. Validation of a new questionnaire with generic and disease-specific qualities: The McGill COPD Quality of Life Questionnaire. Canadian Respiratory Journal, 19, 367–372.PubMedCentralPubMed Pakhale, S., Wood-Dauphinee, S., Spahija, A., Collet, J. P., Maltais, F., Bernard, S., et al. (2012). Respiratory Network of the FRSQ. Validation of a new questionnaire with generic and disease-specific qualities: The McGill COPD Quality of Life Questionnaire. Canadian Respiratory Journal, 19, 367–372.PubMedCentralPubMed
Metagegevens
Titel
A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales
Auteurs
Michael E. Hyland
Ben Whalley
Rupert C. Jones
Matthew Masoli
Publicatiedatum
01-03-2015
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 3/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-014-0801-x

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