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03-01-2021

Health-related quality of life and all-cause mortality among older healthy individuals in Australia and the United States: a prospective cohort study

Auteurs: Aung Zaw Zaw Phyo, Joanne Ryan, David A. Gonzalez-Chica, Robyn L. Woods, Christopher M. Reid, Mark R. Nelson, Anne M. Murray, Danijela Gasevic, Nigel P. Stocks, Rosanne Freak-Poli, the ASPREE Investigator Group

Gepubliceerd in: Quality of Life Research | Uitgave 4/2021

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Abstract

Purpose

Previous research has demonstrated that lower health-related quality of life (HRQoL) is associated with higher morbidity and mortality, especially in-patient groups. The association of HRQoL with all-cause mortality in community samples requires further investigation. This study aimed to examine whether HRQoL predicts all-cause mortality in older healthy community-dwelling people from Australia and the United States (U.S.) enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) trial. We also explored whether this association varies by gender or country.

Method

A prospective cohort of 19,106 individuals aged 65–98 years, who were without a dementia diagnosis or a known major life-limiting disease, and completed the 12-item short-form-HRQoL at recruitment (2010–2014). They were followed until June 2017. Cox proportional-hazard models were used to determine the association between the physical (PCS) and mental component scores (MCS) of HRQoL and all-cause mortality, adjusting for sociodemographic factors, health-related behaviours and clinical measures. Hazards ratios were estimated for every 10-unit increase in PCS or MCS.

Results

There were 1052 deaths over a median 4.7-years (interquartile range 3.6–5.7) of follow-up, with 11.9 events per 1000 person-years. Higher PCS was associated with lower all-cause mortality (HR 0.83, 95% CI 0.77, 0.89) in the entire sample, while higher MCS was associated with lower mortality among U.S. participants only (HR 0.78, 95% CI 0.63, 0.95). Gender differences in the association of either PCS or MCS with mortality were not observed.

Conclusion

Our large study provides evidence that HRQoL is inversely associated with all-cause mortality among initially healthy older people.
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Metagegevens
Titel
Health-related quality of life and all-cause mortality among older healthy individuals in Australia and the United States: a prospective cohort study
Auteurs
Aung Zaw Zaw Phyo
Joanne Ryan
David A. Gonzalez-Chica
Robyn L. Woods
Christopher M. Reid
Mark R. Nelson
Anne M. Murray
Danijela Gasevic
Nigel P. Stocks
Rosanne Freak-Poli
the ASPREE Investigator Group
Publicatiedatum
03-01-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02723-y