Experiences of mothers of adult children with autism spectrum disorder (ASD) often are highlighted, with less attention on fathers’ caregiving experiences. Less than 2% of research on caregiving has focused on fathers. However, the predominance of literature among father caregivers examines the experiences of fathers of young children, rather than fathers of adolescents and adults. The present study examines the influence of caregiver burden, perceived informal social support, and number of formal social supports on quality of life reported by a sample of 57 fathers of adult children diagnosed with ASD. Multiple linear regression analysis indicated developmental burden was negatively related to quality of life, with informal social support positively related to quality of life. These findings illustrate the need for professionals to acknowledge the role of fathers in their caregiving roles and encourage them to join or develop social support networks. Extending additional efforts to include fathers of adult children with ASD in both research and practice is important. Understanding the experiences and voices of father caregivers is needed and should be prioritized to enhance the lives of father caregivers, adult children with ASD, and the overall family unit.