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Gepubliceerd in: Quality of Life Research 2/2017

08-08-2016

Depression risk in patients with late-onset rheumatoid arthritis in Germany

Auteurs: Julia Drosselmeyer, Louis Jacob, Wolfgang Rathmann, Michael A. Rapp, Karel Kostev

Gepubliceerd in: Quality of Life Research | Uitgave 2/2017

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Abstract

Goal

The goal of this study was to determine the prevalence of depression and its risk factors in patients with late-onset rheumatoid arthritis (RA) treated in German primary care practices.

Methods

Longitudinal data from general practices (n=1072) throughout Germany were analyzed. Individuals initially diagnosed with RA (2009–2013) were identified, and 7301 patients were included and matched (1:1) to 7301 controls. The primary outcome measure was the initial diagnosis of depression within 5 years after the index date in patients with and without RA. Cox proportional hazards models were used to adjust for confounders.

Results

The mean age was 72.2 years (SD: 7.6 years). A total of 34.9 % of patients were men. Depression diagnoses were present in 22.0 % of the RA group and 14.3 % of the control group after a 5-year follow-up period (p < 0.001). In the multivariate regression model, RA was a strong risk factor for the development of depression (HR: 1.55, p < 0.001). There was significant interaction of RA and diagnosed inflammatory polyarthropathies (IP) (RA*IP interaction: p < 0.001). Furthermore, dementia, cancer, osteoporosis, hypertension, and diabetes were associated with a higher risk of developing depression (p values <0.001).

Conclusion

The risk of depression is significantly higher in patients with late-onset RA than in patients without RA for subjects treated in primary care practices in Germany. RA patients should be screened routinely for depression in order to ensure improved treatment and management.
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Metagegevens
Titel
Depression risk in patients with late-onset rheumatoid arthritis in Germany
Auteurs
Julia Drosselmeyer
Louis Jacob
Wolfgang Rathmann
Michael A. Rapp
Karel Kostev
Publicatiedatum
08-08-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1387-2

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