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28-07-2016

The challenge of measuring intra-individual change in fatigue during cancer treatment

Auteurs: Carol M. Moinpour, Gary W. Donaldson, Kimberly M. Davis, Arnold L. Potosky, Roxanne E. Jensen, Julie R. Gralow, Anthony L. Back, Jimmy J. Hwang, Jihye Yoon, Debra L. Bernard, Deena R. Loeffler, Nan E. Rothrock, Ron D. Hays, Bryce B. Reeve, Ashley Wilder Smith, Elizabeth A. Hahn, David Cella

Gepubliceerd in: Quality of Life Research | Uitgave 2/2017

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Abstract

Purpose

To evaluate how well three different patient-reported outcomes (PROs) measure individual change.

Methods

Two hundred and fourteen patients (from two sites) initiating first or new chemotherapy for any stage of breast or gastrointestinal cancer participated. The 13-item FACIT Fatigue scale, a 7-item PROMIS® Fatigue Short Form (PROMIS 7a), and the PROMIS® Fatigue computer adaptive test (CAT) were administered monthly online for 6 months. Reliability of measured change was defined, under a population mixed effects model, as the ratio of estimated systematic variance in rate of change to the estimated total variance of measured individual differences in rate of change. Precision of individual measured change, the standard error of measurement of change, was given by the square root of the rate-of-change sampling variance. Linear and quadratic models were examined up to 3 and up to 6 months.

Results

A linear model for measured change showed the following by 6 and 3 months, respectively: PROMIS CAT (0.363 and 0.342); PROMIS SF (0.408 and 0.533); FACIT (0.459 and 0.473). Quadratic models offered no noteworthy improvement over linear models. Both reliability and precision results demonstrate the need to improve the measurement of intra-individual change.

Conclusions

These results illustrate the challenge of reliably measuring individual change in fatigue with a level of confidence required for intervention. Optimizing clinically useful measurement of intra-individual differences over time continues to pose a challenge for PROs.
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Metagegevens
Titel
The challenge of measuring intra-individual change in fatigue during cancer treatment
Auteurs
Carol M. Moinpour
Gary W. Donaldson
Kimberly M. Davis
Arnold L. Potosky
Roxanne E. Jensen
Julie R. Gralow
Anthony L. Back
Jimmy J. Hwang
Jihye Yoon
Debra L. Bernard
Deena R. Loeffler
Nan E. Rothrock
Ron D. Hays
Bryce B. Reeve
Ashley Wilder Smith
Elizabeth A. Hahn
David Cella
Publicatiedatum
28-07-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1372-9