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15-04-2020 | Brief Report | Uitgave 12/2020

Journal of Autism and Developmental Disorders 12/2020

Brief Report: Association of Complicated Appendicitis in Children with Autism Spectrum Disorders

Journal of Autism and Developmental Disorders > Uitgave 12/2020
Patrick T. Reeves, Apryl Susi, Elizabeth Hisle-Gorman, Gregory H. Gorman, Cade Nylund
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Disclaimer: This work was prepared as part of the official duties of Drs. Reeves, Hisle-Gorman, Gorman, Nylund and Ms. Susi, who are employed by the United States Army, and Air Force, and Department of Defense, respectively. The views expressed in this article are those of the authors and do not reflect the official policy or position of the United States Army, Navy, Air Force, Department of Defense, or the United States Government.

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Appendicitis is the most common surgical emergency in children and can lead to significant complications. The aim of our study was to determine whether children with autism spectrum disorders (ASD) are at increased risk for appendicitis and its complications compared to neurotypical (NT) peers. From 2000 to 2013, 292,572 children were included (n = 48,762 ASD). ASD children exhibited an incidence of 8.66 appendicitis cases per 10,000 person-years, P > 0.05. There was an increased risk of perforation in ASD children age 15–17 years-old (OR 2.25; 95% CI 1.15–4.42) as well as an increased odds of sepsis (OR 3.44, 95% CI 1.43–8.27). Providers should display heightened awareness for the risk of complicated appendicitis in children with ASD.

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