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11-04-2020 | Original Paper | Uitgave 12/2020 Open Access

Journal of Autism and Developmental Disorders 12/2020

Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis

Journal of Autism and Developmental Disorders > Uitgave 12/2020
Marta Del Valle Rubido, Eric Hollander, James T. McCracken, Frederick Shic, Jana Noeldeke, Lauren Boak, Omar Khwaja, Shamil Sadikhov, Paulo Fontoura, Daniel Umbricht
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The online version of this article (https://​doi.​org/​10.​1007/​s10803-020-04493-5) contains supplementary material, which is available to authorized users.
The original version of this article was revised: the errors in table 2 have been corrected.
A correction to this article is available online at https://​doi.​org/​10.​1007/​s10803-020-04522-3.

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Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials

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