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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2019

31-10-2018 | Original Paper

ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males

Auteurs: Leonard Abbeduto, Angela John Thurman, Andrea McDuffie, Jessica Klusek, Robyn Tempero Feigles, W. Ted Brown, Danielle J. Harvey, Tatyana Adayev, Giuseppe LaFauci, Carl Dobkins, Jane E. Roberts

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2019

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Abstract

Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed.
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Metagegevens
Titel
ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males
Auteurs
Leonard Abbeduto
Angela John Thurman
Andrea McDuffie
Jessica Klusek
Robyn Tempero Feigles
W. Ted Brown
Danielle J. Harvey
Tatyana Adayev
Giuseppe LaFauci
Carl Dobkins
Jane E. Roberts
Publicatiedatum
31-10-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3796-2

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