Skip to main content
Top
Gepubliceerd in:

05-08-2022 | Original Article

The COVID-19 pandemic and children with PANS/PANDAS: an evaluation of symptom severity, telehealth, and vaccination hesitancy

Auteurs: Sarah L O’Dor, JS Zagaroli, RM Belisle, MA Hamel, OM Downer, S Homayoun, KA Williams

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2024

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The current study assessed the impact of the COVID-19 pandemic on children with PANS/PANDAS, a condition characterized by sudden-onset obsessive-compulsive, tic, or restrictive eating symptoms following infection. We conducted an anonymous survey between February and June 2021 of 254 self-reported caregivers of minors with PANS/PANDAS. Caregivers answered questions regarding PANS/PANDAS symptoms, telehealth care, and intention to vaccinate their child against COVID-19. PANS/PANDAS symptoms during COVID-19 infections were assessed when applicable. Children’s OCD symptoms and coercive behaviors towards caregivers, along with the caregivers’ mental health, relationship satisfaction, and burden, were assessed using standardized questionnaires. A majority of respondents endorsed a negative impact on their child’s friendships, relationships with extended family, hobbies, and academic skills due to the pandemic. Children with suspected or diagnosed COVID-19 experienced new or worsened psychiatric symptoms, particularly mood lability, OCD, and anxiety. Telehealth care was the preferred treatment modality if the child had mild symptoms of PANS/PANDAS. A majority of caregivers reported high levels of relationship dissatisfaction and caregiver burden. As expected, these data suggest an overall negative impact of the COVID-19 pandemic on children with PANS/PANDAS and their caregivers.
Literatuur
1.
go back to reference O’Connor RC, Wetherall K, Cleare S, McClelland H, Melson AJ, Niedzwiedz CL et al (2021) Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study. Br J Psychiatry 218:326–333CrossRefPubMed O’Connor RC, Wetherall K, Cleare S, McClelland H, Melson AJ, Niedzwiedz CL et al (2021) Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study. Br J Psychiatry 218:326–333CrossRefPubMed
2.
go back to reference Benatti B, Albert U, Maina G, Fiorillo A, Celebre L, Giorone N et al (2020) What happened to patients with Obsessive Compulsive Disorder during the COVID-19 pandemic? A multicentre report from tertiary clinics in northern italy. Front Psychiatry 11:720CrossRefPubMedPubMedCentral Benatti B, Albert U, Maina G, Fiorillo A, Celebre L, Giorone N et al (2020) What happened to patients with Obsessive Compulsive Disorder during the COVID-19 pandemic? A multicentre report from tertiary clinics in northern italy. Front Psychiatry 11:720CrossRefPubMedPubMedCentral
3.
go back to reference Nissen JB, Højgaard D, Thomsen PH (2020) The immediate effect of COVID-19 pandemic on children and adolescents with obsessive compulsive disorder. BMC Psychiatry 20:1–10CrossRef Nissen JB, Højgaard D, Thomsen PH (2020) The immediate effect of COVID-19 pandemic on children and adolescents with obsessive compulsive disorder. BMC Psychiatry 20:1–10CrossRef
4.
go back to reference Tanir Y, Karayagmurlu A, Kaya I, Kaynar TB, Yürkmen G, Dambasan BN et al (2020) Exacerbation of obsessive compulsive disorder symptoms in children and adolescents during COVID-19 pandemic. Psychiatry Res 293:113363CrossRefPubMedPubMedCentral Tanir Y, Karayagmurlu A, Kaya I, Kaynar TB, Yürkmen G, Dambasan BN et al (2020) Exacerbation of obsessive compulsive disorder symptoms in children and adolescents during COVID-19 pandemic. Psychiatry Res 293:113363CrossRefPubMedPubMedCentral
5.
go back to reference Kompaniyets L, Agathis N, Nelson JM (2021) Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children. JAMA Netw Open 4:e2111182–e2111182CrossRefPubMedPubMedCentral Kompaniyets L, Agathis N, Nelson JM (2021) Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children. JAMA Netw Open 4:e2111182–e2111182CrossRefPubMedPubMedCentral
6.
go back to reference Mirfazeli FS, Sarabi-Jamab A, Jahanbakhshi A, Kordi A, Javadnia P, Shariat SV et al (2020) Neuropsychiatric manifestations of COVID-19 can be clustered in three distinct symptom categories. Sci Rep 10:20957CrossRefPubMedPubMedCentral Mirfazeli FS, Sarabi-Jamab A, Jahanbakhshi A, Kordi A, Javadnia P, Shariat SV et al (2020) Neuropsychiatric manifestations of COVID-19 can be clustered in three distinct symptom categories. Sci Rep 10:20957CrossRefPubMedPubMedCentral
7.
go back to reference Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S et al (1998) Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 155:264–271CrossRefPubMed Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S et al (1998) Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 155:264–271CrossRefPubMed
8.
go back to reference Swedo SE(2012) From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).Pediatr. Ther.02 Swedo SE(2012) From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).Pediatr. Ther.02
9.
go back to reference Swedo SE, Frankovich J, Murphy TK (2017) Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome. J Child Adolesc Psychopharmacol 27:562–565CrossRefPubMedPubMedCentral Swedo SE, Frankovich J, Murphy TK (2017) Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome. J Child Adolesc Psychopharmacol 27:562–565CrossRefPubMedPubMedCentral
10.
go back to reference Calaprice D, Tona J, Murphy TK (2018) Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population. J Child Adolesc Psychopharmacol 28(2):92–103CrossRefPubMedPubMedCentral Calaprice D, Tona J, Murphy TK (2018) Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population. J Child Adolesc Psychopharmacol 28(2):92–103CrossRefPubMedPubMedCentral
11.
go back to reference O’Dor S, Homayoun, S, Downer, OM, Hamel, MA, Zagaroli, JS, Williams, KA et al (2022) A survey of demographics, symptom course, family history, and barriers to treatment in children with Pediatric Acute Onset Neuropsychiatric Disorders (PANS) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). J. Child Adolesc. Psychopharmacol. In Press. O’Dor S, Homayoun, S, Downer, OM, Hamel, MA, Zagaroli, JS, Williams, KA et al (2022) A survey of demographics, symptom course, family history, and barriers to treatment in children with Pediatric Acute Onset Neuropsychiatric Disorders (PANS) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). J. Child Adolesc. Psychopharmacol. In Press.
12.
go back to reference Gromark C, Harris RA, Wickström R, Horne A, Silverberg-Mörse M, Serlachius E, Mataix-Cols D (2019) Establishing a Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic: Baseline Clinical Features of the Pediatric Acute-Onset Neuropsychiatric Syndrome Cohort at Karolinska Institutet. J Child Adolesc Psychopharmacol 29(8):625–633CrossRefPubMedPubMedCentral Gromark C, Harris RA, Wickström R, Horne A, Silverberg-Mörse M, Serlachius E, Mataix-Cols D (2019) Establishing a Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic: Baseline Clinical Features of the Pediatric Acute-Onset Neuropsychiatric Syndrome Cohort at Karolinska Institutet. J Child Adolesc Psychopharmacol 29(8):625–633CrossRefPubMedPubMedCentral
13.
go back to reference Calaprice D, Tona J, Parker-Athill EC, Murphy TK (2017) A Survey of Pediatric Acute-Onset Neuropsychiatric Syndrome Characteristics and Course. J Child Adolesc Psychopharmacol 27(7):607–618CrossRefPubMed Calaprice D, Tona J, Parker-Athill EC, Murphy TK (2017) A Survey of Pediatric Acute-Onset Neuropsychiatric Syndrome Characteristics and Course. J Child Adolesc Psychopharmacol 27(7):607–618CrossRefPubMed
14.
go back to reference Cantor JH, McBain RK, Pera MF, Bravata DM, Whaley CM (2021) Who Is (and Is Not) Receiving Telemedicine Care During the COVID-19 Pandemic. Am J Prev Med 61:434–438CrossRefPubMedPubMedCentral Cantor JH, McBain RK, Pera MF, Bravata DM, Whaley CM (2021) Who Is (and Is Not) Receiving Telemedicine Care During the COVID-19 Pandemic. Am J Prev Med 61:434–438CrossRefPubMedPubMedCentral
15.
go back to reference Cunningham NR, Ely SL, Barber Garcia BN, Bowden J (2021) Addressing Pediatric Mental Health Using Telehealth During Coronavirus Disease-2019 and Beyond: A Narrative Review. Acad Pediatr 21:1108–1117CrossRefPubMedPubMedCentral Cunningham NR, Ely SL, Barber Garcia BN, Bowden J (2021) Addressing Pediatric Mental Health Using Telehealth During Coronavirus Disease-2019 and Beyond: A Narrative Review. Acad Pediatr 21:1108–1117CrossRefPubMedPubMedCentral
16.
go back to reference Viswanath K, Bekalu M, Dhawan D, Pinnamaneni R, Lang J, McLoud R (2021) Individual and social determinants of COVID-19 vaccine uptake. BMC Public Health 21:818CrossRefPubMedPubMedCentral Viswanath K, Bekalu M, Dhawan D, Pinnamaneni R, Lang J, McLoud R (2021) Individual and social determinants of COVID-19 vaccine uptake. BMC Public Health 21:818CrossRefPubMedPubMedCentral
17.
go back to reference Cooperstock MS, Swedo SE, Pasternack MS, Murphy TK (2017) Clinical management of pediatric acute-onset neuropsychiatric syndrome: Part III—Treatment and prevention of infections. J Child Adolesc Psychopharmacol 27:594–606CrossRefPubMedPubMedCentral Cooperstock MS, Swedo SE, Pasternack MS, Murphy TK (2017) Clinical management of pediatric acute-onset neuropsychiatric syndrome: Part III—Treatment and prevention of infections. J Child Adolesc Psychopharmacol 27:594–606CrossRefPubMedPubMedCentral
18.
go back to reference U.S, Census, Bureau (2021) & U.S. Postal Service. United States Zip Codes. unitedstateszipcodes.org U.S, Census, Bureau (2021) & U.S. Postal Service. United States Zip Codes. unitedstateszipcodes.org
19.
go back to reference Storch EA, Murphy TK, Adkins JW, Lewin AB, Geffken GR, Johns NB et al (2006) The children’s Yale-Brown obsessive–compulsive scale: Psychometric properties of child-and parent-report formats. J Anxiety Disord 20:1055–1070CrossRefPubMed Storch EA, Murphy TK, Adkins JW, Lewin AB, Geffken GR, Johns NB et al (2006) The children’s Yale-Brown obsessive–compulsive scale: Psychometric properties of child-and parent-report formats. J Anxiety Disord 20:1055–1070CrossRefPubMed
20.
go back to reference Lebowitz ER, Vitulano LA, Omer H (2011) Coercive and disruptive behaviors in pediatric obsessive compulsive disorder: A qualitative analysis. Psychiatry Interpers Biol Process 74:362–371CrossRef Lebowitz ER, Vitulano LA, Omer H (2011) Coercive and disruptive behaviors in pediatric obsessive compulsive disorder: A qualitative analysis. Psychiatry Interpers Biol Process 74:362–371CrossRef
21.
go back to reference Lovibund S, Lovibund P (1995) Manual for the depression anxiety stress scales. Syd. Psychol. Found. Lovibund S, Lovibund P (1995) Manual for the depression anxiety stress scales. Syd. Psychol. Found.
22.
go back to reference Henry JD, Crawford JR (2005) The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 44(2):227–239CrossRefPubMed Henry JD, Crawford JR (2005) The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 44(2):227–239CrossRefPubMed
23.
go back to reference Novak M, Guest C (1989) Application of a multidimensional caregiver burden inventory. Gerontologist 29:798–803CrossRefPubMed Novak M, Guest C (1989) Application of a multidimensional caregiver burden inventory. Gerontologist 29:798–803CrossRefPubMed
24.
go back to reference Farmer C, Thienemann M, Leibold C, Kamalani G, Sauls B, Frankovich J (2018) Psychometric Evaluation of the Caregiver Burden Inventory in Children and Adolescents With PANS. J Pediatr Psychol 43(7):749–757CrossRefPubMedPubMedCentral Farmer C, Thienemann M, Leibold C, Kamalani G, Sauls B, Frankovich J (2018) Psychometric Evaluation of the Caregiver Burden Inventory in Children and Adolescents With PANS. J Pediatr Psychol 43(7):749–757CrossRefPubMedPubMedCentral
25.
go back to reference Funk JL, Rogge RD (2007) Testing the ruler with item response theory: increasing precision of measurement for relationship satisfaction with the Couples Satisfaction Index. J Fam Psychol 21:572CrossRefPubMed Funk JL, Rogge RD (2007) Testing the ruler with item response theory: increasing precision of measurement for relationship satisfaction with the Couples Satisfaction Index. J Fam Psychol 21:572CrossRefPubMed
26.
go back to reference IBM Corp (2016) IBM SPSS Statistics for Macintosh. IBM Corp. IBM Corp (2016) IBM SPSS Statistics for Macintosh. IBM Corp.
27.
go back to reference Park A, Smart C, Taylor R, Watkins M (2021) An extremely detailed map of the 2020 election. The New York Times Park A, Smart C, Taylor R, Watkins M (2021) An extremely detailed map of the 2020 election. The New York Times
29.
go back to reference Lund DA, Wright SD, Caserta MS, Utz RL (2006) Enhancing the quality of daily life for caregivers and care receivers caregiving. Recognizing the need for respite. The University of Utah Center on Aging. Lund DA, Wright SD, Caserta MS, Utz RL (2006) Enhancing the quality of daily life for caregivers and care receivers caregiving. Recognizing the need for respite. The University of Utah Center on Aging.
30.
go back to reference Guido CA, Loffredo L, Zicari AM, Savasta S, Gagliano A, Brindisi G et al (2021) The Impact of the COVID-19 Epidemic During the Lockdown on Children With the Pediatric Acute-Onset Neuropsychiatric Syndrome: The Importance of Environmental Factors on Clinical Conditions. Front Neurol 12:702356–702356CrossRefPubMedPubMedCentral Guido CA, Loffredo L, Zicari AM, Savasta S, Gagliano A, Brindisi G et al (2021) The Impact of the COVID-19 Epidemic During the Lockdown on Children With the Pediatric Acute-Onset Neuropsychiatric Syndrome: The Importance of Environmental Factors on Clinical Conditions. Front Neurol 12:702356–702356CrossRefPubMedPubMedCentral
31.
go back to reference Lebowitz ER, Storch EA, MacLeod J, Leckman JF (2015) Clinical and Family Correlates of Coercive-Disruptive Behavior in Children and Adolescents with Obsessive-Compulsive Disorder. J Child Fam Stud 24:2589–2597CrossRef Lebowitz ER, Storch EA, MacLeod J, Leckman JF (2015) Clinical and Family Correlates of Coercive-Disruptive Behavior in Children and Adolescents with Obsessive-Compulsive Disorder. J Child Fam Stud 24:2589–2597CrossRef
32.
go back to reference Raviv T, Warren CM, Washburn JJ, Kanaley M, Eihentale L, Goldenthal HJ et al (2021) Caregiver Perceptions of Children’s Psychological Well-being During the COVID-19 Pandemic. JAMA Netw Open 4:e2111103–e2111103CrossRefPubMedPubMedCentral Raviv T, Warren CM, Washburn JJ, Kanaley M, Eihentale L, Goldenthal HJ et al (2021) Caregiver Perceptions of Children’s Psychological Well-being During the COVID-19 Pandemic. JAMA Netw Open 4:e2111103–e2111103CrossRefPubMedPubMedCentral
33.
go back to reference Carlson-Green B, Morris RD, Krawiecki N (1995) Family and Illness Predictors of Outcome in Pediatric Brain Tumors. J Pediatr Psychol 20:769–784CrossRefPubMed Carlson-Green B, Morris RD, Krawiecki N (1995) Family and Illness Predictors of Outcome in Pediatric Brain Tumors. J Pediatr Psychol 20:769–784CrossRefPubMed
34.
go back to reference Osborne LA, McHugh L, Saunders J, Reed P (2008) Parenting Stress Reduces the Effectiveness of Early Teaching Interventions for Autistic Spectrum Disorders. J Autism Dev Disord 38:1092–1103CrossRefPubMed Osborne LA, McHugh L, Saunders J, Reed P (2008) Parenting Stress Reduces the Effectiveness of Early Teaching Interventions for Autistic Spectrum Disorders. J Autism Dev Disord 38:1092–1103CrossRefPubMed
35.
go back to reference Wosik J, Fudim M, Cameron B, Gellad ZF, Cho A, Phinney D et al (2020) Telehealth transformation: COVID-19 and the rise of virtual care. J Am Med Inform Assoc 27:957–962CrossRefPubMedPubMedCentral Wosik J, Fudim M, Cameron B, Gellad ZF, Cho A, Phinney D et al (2020) Telehealth transformation: COVID-19 and the rise of virtual care. J Am Med Inform Assoc 27:957–962CrossRefPubMedPubMedCentral
36.
go back to reference Goldman RD, Yan TD, Seiler M, Parra Cotanda C, Brown JC, Klein EJ et al (2020) Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey. Vaccine 38:7668–7673CrossRefPubMedPubMedCentral Goldman RD, Yan TD, Seiler M, Parra Cotanda C, Brown JC, Klein EJ et al (2020) Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey. Vaccine 38:7668–7673CrossRefPubMedPubMedCentral
37.
go back to reference Yilmaz M, Sahin MK (2021) Parents’ willingness and attitudes concerning the COVID-19 vaccine: A cross-sectional study. Int J Clin Pract 75:e1436CrossRef Yilmaz M, Sahin MK (2021) Parents’ willingness and attitudes concerning the COVID-19 vaccine: A cross-sectional study. Int J Clin Pract 75:e1436CrossRef
38.
go back to reference Olson O, Berry C, Kumar N (2020) Addressing Parental Vaccine Hesitancy towards Childhood Vaccines in the United States: A Systematic Literature Review of Communication Interventions and Strategies. Vaccines 8:590CrossRefPubMedPubMedCentral Olson O, Berry C, Kumar N (2020) Addressing Parental Vaccine Hesitancy towards Childhood Vaccines in the United States: A Systematic Literature Review of Communication Interventions and Strategies. Vaccines 8:590CrossRefPubMedPubMedCentral
39.
go back to reference Gamucci A, Uccella S, Sciarretta L, D’Apruzzo M, Calevo MG, Mancardi MM, Veneselli E, De Grandis E (2019) PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol. J Child Adolesc Psychopharmacol 29(4):305–312CrossRefPubMed Gamucci A, Uccella S, Sciarretta L, D’Apruzzo M, Calevo MG, Mancardi MM, Veneselli E, De Grandis E (2019) PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol. J Child Adolesc Psychopharmacol 29(4):305–312CrossRefPubMed
Metagegevens
Titel
The COVID-19 pandemic and children with PANS/PANDAS: an evaluation of symptom severity, telehealth, and vaccination hesitancy
Auteurs
Sarah L O’Dor
JS Zagaroli
RM Belisle
MA Hamel
OM Downer
S Homayoun
KA Williams
Publicatiedatum
05-08-2022
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2024
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-022-01401-z

Andere artikelen Uitgave 2/2024

Child Psychiatry & Human Development 2/2024 Naar de uitgave