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Child Psychiatry & Human Development
Gepubliceerd in: Child Psychiatry & Human Development 2/2024

10-09-2022 | Original Article

Genetic Variations in Elements of the Oxytocinergic Pathway are Associated with Attention/Hyperactivity Problems and Anxiety Problems in Childhood

Auteurs: Laísa Camerini, Gabriel Zurchimitten, Bertha Bock, Janaína Xavier, Clarissa Ribeiro Bastos, Evânia Martins, Ana Paula Ardais, Janaína Vieira dos Santos Motta, Andressa Jacondino Pires, Mariana Bonati de Matos, Luciana de Ávila Quevedo, Ricardo Tavares Pinheiro, Gabriele Ghisleni

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2024

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Abstract

Genetic alterations related to oxytocin system seem to influence the neurobiology of attention-deficit hyperactivity disorder and anxiety problems leading to greater functional, social and emotional impairment. Here, we analyzed the association of OXTR rs2254298 and CD38 rs6449182 variants with attention/hyperactivity problems and anxiety problems in children. The study enrolled 292 children and adjusted regression model revealed OXTR rs2254298 AA genotype as a risk factor for attention deficit/hyperactivity problems (PR: 2.37; PadjFDR = 0.006), attention problems (PR: 2.71; PadjFDR = 0.003) and anxiety problems (PR: 1.92; PadjFDR = 0.018). CD38 rs6449182 G allele showed as a risk factor for attention deficit/hyperactivity problems (PR: 1.56; PadjFDR = 0.028). Moreover, in silico approach for regulatory roles found markers that influence chromatin accessibility and transcription capacity. Together, these data provide genetic information of oxytocin in developmental and behavioral disorders opening a range of opportunities for future studies that clarify their neurobiology in childhood.
vorige artikel Assessing Adolescent Functioning from Different Perspectives: Extending the Validation of the Adolescent Functioning Scale (AFS)
volgende artikel Emotion Identification for Self and Other Associated with Callous-Unemotional Traits and Sex Differences in Early Adolescents
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Metagegevens
Titel
Genetic Variations in Elements of the Oxytocinergic Pathway are Associated with Attention/Hyperactivity Problems and Anxiety Problems in Childhood
Auteurs
Laísa Camerini
Gabriel Zurchimitten
Bertha Bock
Janaína Xavier
Clarissa Ribeiro Bastos
Evânia Martins
Ana Paula Ardais
Janaína Vieira dos Santos Motta
Andressa Jacondino Pires
Mariana Bonati de Matos
Luciana de Ávila Quevedo
Ricardo Tavares Pinheiro
Gabriele Ghisleni
Publicatiedatum
10-09-2022
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2024
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-022-01419-3

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