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Journal of Autism and Developmental Disorders

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21-01-2021 | Original Paper

Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children

Auteurs: Jenna B. Lebersfeld, Marissa Swanson, Christian D. Clesi, Sarah E. O’Kelley

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2021

Abstract

The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) and the Autism Diagnostic Interview, Revised (ADI-R) have high accuracy as diagnostic instruments in research settings, while evidence of accuracy in clinical settings is less robust. This meta-analysis focused on efficacy of these measures in research versus clinical settings. Articles (n = 22) were analyzed using a hierarchical summary receiver operating characteristics (HSROC) model. ADOS-2 performance was stronger than the ADI-R. ADOS-2 sensitivity and specificity ranged from .89-.92 and .81-.85, respectively. ADOS-2 accuracy in research compared with clinical settings was mixed. ADI-R sensitivity and specificity were .75 and .82, respectively, with higher specificity in research samples (Research = .85, Clinical = .72). A small number of clinical studies were identified, indicating ongoing need for investigation outside research settings.

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Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author.CrossRef

Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet, 368, 210–15.CrossRef

Camodeca, A. (2018). Utility of three N-Item scales of the child behavior checklist 6–18 in autism diagnosis. Research in Autism Spectrum Disorder, 51, 75–85. https://doi.org/10.1016/j.rasd.2018.04.004.CrossRef

Bishop, S. L., Huerta, M., Gotham, K., Havdahl, K. A., Pickles, A., Duncan, A., et al. (2017). The Autism Symptom Interview, School-Age: A brief telephone interview to identify autism spectrum disorders in 5-to-12-year-old children. Autism Research, 10(1), 78–88. https://doi.org/10.1002/aur.1645.CrossRefPubMed

Cox, A., Klein, K., Charman, T., Baird, G., Baron-Cohen, S., Swettenham, J., et al. (1999). Autism spectrum disorders at 20 and 42 months of age: stability of clinical and ADI-R diagnosis. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 40(5), 719–32.CrossRef

De Bildt, A., Sytema, S., Ketelaars, C., Kraijer, D., Mulder, E., Volkmar, F., & Minderaa, R. (2004). Interrelationship between autism diagnostic observation schedule-generic (ADOS-G), autism diagnostic interview-revised (ADI-R), and the diagnostic and statistical manual of mental disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. Journal of Autism and Developmental Disorders, 34(2), 129–137.CrossRef

De Bildt, A., Sytema, S., van Lang, N. D. J., Minderaa, R. B., van Engeland, H., & de Jonge, M. V. (2009). Evaluation of the ADOS revised algorithm: the applicability in 558 Dutch children and adolescents. Journal of Autism and Developmental Disorders, 39(9), 1350–8. https://doi.org/10.1007/s10803-009-0749-9.CrossRefPubMedPubMedCentral

Deeks, J. J. (2001). Systematic reviews of evaluations of diagnostic and screening tests. British Medical Journal, 323, 157–162.CrossRef

Deeks J. J., Wisniewski S., & Davenport C. (2013). Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0.0. The Cochrane Collaboration, 2013. http://srdta.cochrane.org/.

Dereu, M., Roeyers, H., Raymaekers, R., Meirsschaut, M., & Warreyn, P. (2012). How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder. European Child Adolesc Psychiatry, 21(10), 541–551.CrossRef

DiLavore, P. C., Lord, C., & Rutter, M. (1995). The pre-linguistic autism diagnostic observation schedule. Journal of Autism and Developmental Disorders, 25(4), 355–379.CrossRef

Dorlack, T. P., Myers, O. B., & Kodituwakku, P. W. (2018). A comparative analysis of the ADOS-G and ADOS-2 algorithms: preliminary findings. Journal of Autism and Developmental Disorders, 1–12.

Dykens, E. M., Roof, E., Hunt-Hawkins, J., Dankner, N., Lee, E. B., Shivers, C. M., et al. (2017). Diagnoses and characteristics of autism spectrum disorders in children with Prader-Willi syndrome. Journal of Neurodevelopmental Disorders, 9(18), 1–12. https://doi.org/10.1186/s11689-017-9200-2.CrossRef

Falkmer, T., Anderson, K., Falkmer, M., & Horlin, C. (2013). Diagnostic procedures in autism spectrum disorders: A systematic literature review. European Child & Adolescent Psychiatry, 22(6), 329–40. https://doi.org/10.1007/s00787-013-0375-0.CrossRef

Gilchrist, A., Green, J., Cox, A., Burton, D., Rutter, M., & Le Couteur, A. (2001). Development and current functioning in adolescents with Asperger syndrome: a comparative study. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 42(2), 227–40.CrossRef

Gillentine, M. A., Berry, L. N., Goin-Kochel, R. P., Ali, M. A., Ge, J., Guffey, D., et al. (2017). The cognitive and behavioral phenotypes of individuals with CHRNA7 duplications. Journal of Autism and Developmental Disorders, 47(3), 549–562. https://doi.org/10.1007/s10803-016-2961-8.CrossRefPubMedPubMedCentral

Gotham, K., Risi, S., Dawson, G., Tager-Flusberg, H., Joseph, R., Carter, A., et al. (2008). A Replication of the autism diagnostic observation schedule (ADOS) revised algorithms. Journal of the American Academy of Child & Adolescent Psychiatry, 47(6), 642–651. https://doi.org/10.1097/CHI.0b013e31816bffb7.CrossRef

Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The Autism Diagnostic Observation Schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37(4), 613.CrossRef

Gray, K. M., Tonge, B. J., & Sweeney, D. J. (2008). Using the Autism Diagnostic Interview-Revised and the Autism Diagnostic Observation Schedule with young children with developmental delay: evaluating diagnostic validity. Journal of Autism and Developmental Disorders, 38(4), 657–667.CrossRef

Grzadzinski, R., Dick, C., Lord, C., & Bishop, S. (2016). Parent-reported and clinician-observed autism spectrum disorder (ASD) symptoms in children with attention deficit/hyperactivity disorder (ADHD): implications for practice under DSM-5. Molecular Autism, 7(7), 1–12. https://doi.org/10.1186/s13229-016-0072-1.CrossRef

Guthrie, W., Swineford, L. B., Nottke, C., & Wetherby, A. M. (2013). Early diagnosis of autism spectrum disorder: stability and change in clinical diagnosis and symptom presentation. Journal of Child Psychiatry, 54(5), 582–590. https://doi.org/10.1111/jcpp.12008.CrossRef

Harris, S. W., Hess, D., Goodlin-Jones, B., Ferranti, J., Bacalman, S., Barbato, I., et al. (2008). Autism profiles of males with fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 113(6), 427–438. https://doi.org/10.1352/2008.113:427-438.CrossRef

Havdahl, K. A., von Tetzchner, S., Huerta, M., Lord, C., & Bishop, S. L. (2016). Utility of the child behavior checklist as a screener for autism spectrum disorder. Autism Research, 9(1), 33–42. https://doi.org/10.1002/aur.1515.CrossRefPubMed

Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., et al. (2017). Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology. Journal of Psychopharmacology, 32(1), 3–29. https://doi.org/10.1177/0269881117741766.CrossRefPubMed

Kamp-Becker, I., Albertowski, K., Becker, J., Ghahreman, M., Langmann, A., Mingebach, T., Poustka, L., Weber, L., Schmidt, H., Smidt, J., Stehr, T., Roessner, V., Kucharczyk, K., Wolff, N., & Stroth, S., (2018). Diagnostic accuracy of the ADOS and ADOS-2 in clinical practice. European Child \& Adolescent Psychiatry, 1–15.

Kim, S. H., & Lord, C. (2012). Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to 47 months of age. Journal of Child Psychology and Psychiatry, 53(2), 143–151.CrossRef

Langmann, A., Becker, J., Poustka, L., Becker, K., & Kamp-Becker, I. (2017). Diagnostic utility of the autism diagnostic observation schedule in a clinical sample of adolescents and adults. Research in Autism Spectrum Disorders, 34, 34–43.CrossRef

Le Couteur, A., Haden, G., Hammal, D., & McConachie, H. (2008). Diagnosing autism spectrum disorders in pre-school children using two standardised assessment instruments: The ADI-R and the ADOS. Journal of Autism and Developmental Disorders, 38, 362–372. https://doi.org/10.1007/s10803-007-0403-3.CrossRefPubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule – generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRef

Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles, CA: Western Psychological Services.

Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012b). ADOS-2. Autism Diagnostic Observation Schedule. Manual (Part I): Modules 1-4. Western Psychological Services Los Angeles, CA.

Luyster, R., Gotham, K., Guthrie, W., Coffing, M., Petrak, R., Pierce, K., et al. (2009). The Autism diagnostic observation schedule – toddler module: A new module of a standardized diagnostic measure for autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(9), 1305–1320.CrossRef

Maddox, B. B., Brodkin, E. S., Calkins, M. E., Shea, K., Mullan, K., Hostager, J., et al. (2017). The accuracy of the ADOS-2 in identifying autism among adults with complex psychiatric conditions. Journal of Autism and Developmental Disorders, 47(9), 2703–2709. https://doi.org/10.1007/s10803-017-3188-z.CrossRefPubMedPubMedCentral

Mazefsky, C., & Oswald, D. P. (2006). The discriminative ability and diagnostic utility of the ADOS–G, ADI–R, and GARS for children in a clinical setting. Autism, 10(6), 533–549. https://doi.org/10.1177/1362361306068505.CrossRefPubMed

McInnes, M. D., Moher, D., Thombs, B. D., McGrath, T. A., Bossuyt, P. M., Clifford, T., et al. (2018). Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement. JAMA, 319(4), 388–396.CrossRef

Molloy, C., Murray, D. S., Akers, R., Mitchell, T., & Manning-Courtney, P. (2011). Use of the autism diagnostic observation schedule (ADOS) in a clinical setting. Autism, 15(2), 143–162. https://doi.org/10.1177/1362361310379241.CrossRefPubMed

Neuhaus, E., Beauchaine, T. P., Bernier, R. A., & Webb, S. J. (2017). Child and family characteristics moderate agreement between caregiver and clinician report of autism symptoms. Autism Research, 11(3), 476–487.CrossRef

Oosterling, I. J., Roos, S., de Bildt, A., Rommelse, N., de Jonge, M., Visser, J., et al. (2010). Improved diagnostic validity of the ADOS revised algorithms: a replication study in an independent sample. Journal of Autism and Developmental Disorders, 40(6), 689–703. https://doi.org/10.1007/s10803-009-0915-0.CrossRefPubMedPubMedCentral

Papanikolaou, K., Paliokosta, E., Houliaras, G., Vgenopoulou, S., Giouroukou, E., Pehlivanidis, A., et al. (2009). Using the autism diagnostic interview-revised and the autism diagnostic observation schedule-generic for the diagnosis of autism spectrum disorders in a Greek sample with a wide range of intellectual abilities. Journal of Autism and Developmental Disorders, 39(3), 414–420.CrossRef

Penner, M., Anagnostou, E., Andoni, L. Y., & Ungar, W. J. (2017). Systematic review of clinical guidance documents for autism spectrum disorder diagnostic assessment in select regions. Autism, 22(5), 517–527.CrossRef

Reaven, J. A., Hepburn, S. L., & Ross, R. G. (2008). Use of the ADOS and ADI-R in children with psychosis: Importance of clinical judgment. Clinical Child Psychology and Psychiatry, 13(1), 81–94. https://doi.org/10.1177/1359104507086343.CrossRefPubMedPubMedCentral

Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., et al. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45(9), 1094–103.CrossRef

Rutter, C. M. (1995). Regression methods for meta-analysis of diagnostic test data. Academic Radiology, 2, S48–S56.PubMed

Rutter, C. M., & Gatsonis, C. A. (2001). A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Statistics in Medicine, 20(19), 2865–2884.CrossRef

Rutter, M., Le Couteur, A., Lord, C., et al. (2003). Autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services, 29, 30.

Stewart, J. R., Vigil, D. C., Ryst, E., & Yang, W. (2014). Refining best practices for the diagnosis of autism: A comparison between individual healthcare practitioner diagnosis and transdisciplinary assessment. Nevada Journal of Public Health, 11(1), 1.

Takwoingi, Y. & Deeks, J. (2010). MetaDAS: A SAS macro for meta-analysis of diagnostic accuracy studies. User Guide Version 1.3. 2010 July. http://srdta.cochrane.org/.

Tomanik, S. S., Pearson, D. A., Loveland, K. A., Lane, D. M., & Shaw, J. B. (2007). Improving the reliability of autism diagnoses: Examining the utility of adaptive behavior. Journal of Autism and Developmental Disorders, 37(5), 921–928.CrossRef

Ventola, P. E., Kleinman, J., Pandey, J., Barton, M., Allen, S., Green, J., et al. (2006). Agreement among four diagnostic instruments for autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 36(7), 839–47.CrossRef

Vllasaliu, L., Jensen, K., Hoss, S., Landenberger, M., Menze, M., Schütz, M., et al. (2016). Diagnostic instruments for autism spectrum disorder (ASD). The Cochrane Library.

Whiting, P. F., Rutjes, A. W. S., Westwood, M. E., Mallett, S., Deeks, J. J., Reitsma, J. B., et al. (2011). QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Annals of Internal Medicine, 155(8), 529–536. https://doi.org/10.7326/0003-4819-155-8-201110180-00009.CrossRefPubMed

Wiggins, L. D., Reynolds, A., Rice, C. E., Moody, E. J., Bernal, P., Blaskey, L., et al. (2015). Using standardized diagnostic instruments to classify children with autism in the Study to Explore Early Development. Journal of Autism and Developmental Disorders, 45, 1271–1280. https://doi.org/10.1007/s10803-014-2287-3.CrossRefPubMedPubMedCentral

Wiggins, L. D., & Robins, D. L. (2008). Brief Report: excluding the ADI-R behavioral domain improves diagnostic agreement in toddlers. Journal of Autism and Developmental Disorders, 38, 972–976. https://doi.org/10.1007/s10803-007-0456-3.CrossRefPubMed

Zander, E., Sturm, H., & Bӧlte, S. (2015). The added value of the combined use of the autism diagnostic interview-revised and the autism diagnostic observation schedule: Diagnostic validity in a clinical Swedish sample of toddlers and young preschoolers. Autism, 19(2), 187–199.CrossRef

Zander, E., Willfors, C., Berggren, S., Choque-Olsson, N., Coco, C., Elmund, A., et al. (2016). The objectivity of the Autism Diagnostic Observation Schedule (ADOS) in naturalistic clinical settings. European Child Adolescent Psychiatry, 25(7), 769–780.CrossRef

Zander, E., Willfors, C., Berggren, S., Coco, C., Holm, A., Jifält, I., et al. (2017). The interrater reliability of the autism diagnostic interview-revised (ADI-R) in clinical settings. Psychopathology, 50(3), 219–227.CrossRef

Ziats, M. N., Goin-Kochel, R. P., Berry, L. N., Ali, M., Ge, J., Guffey, D., et al. (2016). Genetics in Medicine, 18(11), 1111–1118. https://doi.org/10.1038/gim.2016.9.CrossRefPubMed

Zwaigenbaum, L., Bryson, S. E., Brian, J., Smith, I. M., Roberts, W., Szatmari, P., et al. (2016). Stability of diagnostic assessment for autism spectrum disorder between 18 and 36 months in a high-risk cohort. Autism Research, 9, 790–800. https://doi.org/10.1002/aur.1.CrossRefPubMed

Titel: Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children
Auteurs: Jenna B. Lebersfeld
Marissa Swanson
Christian D. Clesi
Sarah E. O’Kelley
Publicatiedatum: 21-01-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04839-z

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