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Gepubliceerd in: Quality of Life Research 1/2017

20-07-2016 | Brief Communication

Sustained quality of life improvement after intracoronary injection of autologous bone marrow cells in the setting of acute myocardial infarction: results from the BONAMI trial

Auteurs: Guillaume Lamirault, Elodie de Bock, Véronique Sébille, Béatrice Delasalle, Jérôme Roncalli, Sophie Susen, Christophe Piot, Jean-Noël Trochu, Emmanuel Teiger, Yannick Neuder, Thierry Le Tourneau, Alain Manrique, Jean-Benoît Hardouin, Patricia Lemarchand

Gepubliceerd in: Quality of Life Research | Uitgave 1/2017

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Abstract

Purpose

Cardiac cell therapy is a promising treatment for acute myocardial infarction (AMI), leading to cardiac function improvement. However, whether it translates into quality of life (QoL) improvement is unclear. We hypothesized that administration of bone marrow cells (BMC) to patients with AMI improves QoL.

Methods

In the multicenter BONAMI trial (NCT00200707), patients with reperfused AMI and decreased myocardial viability were randomized to intracoronary autologous BMC infusion (n = 52) or state-of-the-art therapy (n = 49). QoL data, derived from the Minnesota Living with Heart Failure questionnaire (MLHFQ), were obtained 1, 3, and 12 months after AMI and analyzed using a Rasch-family model.

Results

Using this model, QoL improved over time in the BMC group (p = 0.025) but not in the control group. Furthermore, the BMC-group patients displayed a better QoL than the control-group patients at 3 and 12 months post-AMI (p = 0.034 and p = 0.003, respectively). These findings were not detected when analyzing MLHFQ data using a standard method. Cardiac function, myocardial viability, mortality, and number of major adverse cardiac events did not differ between treatment groups.

Conclusion

Our results suggest that BMC therapy can improve QoL, stressing the need for confirmation trials and for systematic QoL assessment in cardiac cell therapy trials .

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Metagegevens
Titel
Sustained quality of life improvement after intracoronary injection of autologous bone marrow cells in the setting of acute myocardial infarction: results from the BONAMI trial
Auteurs
Guillaume Lamirault
Elodie de Bock
Véronique Sébille
Béatrice Delasalle
Jérôme Roncalli
Sophie Susen
Christophe Piot
Jean-Noël Trochu
Emmanuel Teiger
Yannick Neuder
Thierry Le Tourneau
Alain Manrique
Jean-Benoît Hardouin
Patricia Lemarchand
Publicatiedatum
20-07-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1366-7