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Journal of Autism and Developmental Disorders

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27-02-2022 | Original Paper

Sexual Dimorphism in Telomere Length in Childhood Autism

Auteurs: Yasin Panahi, Fahimeh Salasar Moghaddam, Khadijeh Babaei, Mohammad Eftekhar, Reza Shervin Badv, Mohammad Reza Eskandari, Mohammad Vafaee-Shahi, Hamid Pezeshk, Mehrdad Pedram

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2023

Abstract

Autism spectrum disorders (ASD) are strikingly more prevalent in males, but the molecular mechanisms responsible for ASD sex-differential risk are poorly understood. Abnormally shorter telomeres have been associated with autism. Examination of relative telomere lengths (RTL) among non-syndromic male (N = 14) and female (N = 10) children with autism revealed that only autistic male children had significantly shorter RTL than typically-developing controls (N = 24) and paired siblings (N = 10). While average RTL of autistic girls did not differ significantly from controls, it was substantially longer than autistic boys. Our findings indicate a sexually-dimorphic pattern of RTL in childhood autism and could have important implications for RTL as a potential biomarker and the role/s of telomeres in the molecular mechanisms responsible for ASD sex-biased prevalence and etiology.

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Titel: Sexual Dimorphism in Telomere Length in Childhood Autism
Auteurs: Yasin Panahi
Fahimeh Salasar Moghaddam
Khadijeh Babaei
Mohammad Eftekhar
Reza Shervin Badv
Mohammad Reza Eskandari
Mohammad Vafaee-Shahi
Hamid Pezeshk
Mehrdad Pedram
Publicatiedatum: 27-02-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05486-2

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