Top

Gepubliceerd in:

09-07-2016

Race-based medical mistrust, medication beliefs and HIV treatment adherence: test of a mediation model in people living with HIV/AIDS

Auteurs: Seth C. Kalichman, Lisa Eaton, Moira O. Kalichman, Tama Grebler, Cynthia Merely, Brandi Welles

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2016

Abstract

Race-based medical mistrust significantly predicts non-adherence to antiretroviral therapy (ART) in people living with HIV. The current study builds on previous research that shows beliefs about medication necessity (i.e., “My medicines protect me from becoming worse”) and concerns (i.e., “Having to take my medicines worries me”) mediate the association between race-based medical mistrust and medication adherence. Racial and ethnic minority men and women living with HIV and receiving ART (N = 178) in a southern US city completed computerized measures of demographic and health characteristics, telephone interviews of race-based medical mistrust and medication beliefs, and unannounced phone-based pill counts for ART adherence. Multiple mediation modeling showed that medical mistrust is related to medication necessity and concerns beliefs and ART adherence. Furthermore, medication necessity beliefs predicted ART adherence. The indirect effect of medical mistrust on adherence through medication necessity beliefs was also significant. Results confirm that medication necessity beliefs, although not concerns beliefs, mediate the association between medical mistrust and ART adherence. Medication necessity beliefs offer a viable target for interventions to improve ART adherence in the context of mistrust that patients may have for medical providers and health care systems.

vorige artikel Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis

volgende artikel Blood pressure outcomes of medication adherence interventions: systematic review and meta-analysis

Altice, F. L., Mostashari, F., & Friedland, G. H. (2001). Trust and the acceptance of and adherence to antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 28, 47–58.CrossRefPubMed

Bangsberg, D., & Deeks, S. G. (2002). Is average adherence to HIV antiretroviral therapy enough? Jounal of General Internal Medicine, 17, 812–813.CrossRef

Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.CrossRefPubMed

Bogart, L. M., Wagner, G., Galvan, F. H., & Banks, D. (2010). Conspiracy beliefs about HIV are related to antiretroviral treatment nonadherence among african american men with HIV. Journal of Acquired Immune Deficiency Syndromes, 53, 648–655.PubMedPubMedCentral

Carrieri, M. P., Villes, V., et al. (2007). Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8). International Journal of Drug Policy, 18, 288–295.CrossRefPubMed

Casagrande, S. S., Gary, T. L., LaVeist, T. A., Gaskin, D. J., & Cooper, L. A. (2007). Perceived discrimination and adherence to medical care in a racially integrated community. Journal of General Internal Medicine, 22, 389–395.CrossRefPubMedPubMedCentral

Dale, S. K., Bogart, L. M., Wagner, G. J., Galvan, F. H., & Klein, D. J. (2014). Medical mistrust is related to lower longitudinal medication adherence among African-American males with HIV. Journal of Health Psychology, 21, 1311–1321.CrossRefPubMed

Earl, T. R., Beach, M. C., Lombe, M., Korthuis, P. T., Sharp, V. L., Cohn, J. A., & Saha, S. (2013). Race, relationships and trust in providers among black patients with HIV/AIDS. Social Work Research, 37, 219–226.CrossRefPubMedPubMedCentral

Fredericksen, R., Feldman, B. J., Brown, T., Schmidt, S., Crane, P. K., Harrington, R. D., & Crane, H. M. (2014). Unannounced telephone-based pill counts: A valid and feasible method for monitoring adherence. AIDS and Behavior, 18, 2265–2273.CrossRefPubMedPubMedCentral

Gaston, G. B., & Alleyne-Green, B. (2013). The impact of African Americans’ beliefs about HIV medical care on treatment adherence: A systematic review and recommendations for interventions. AIDS and Behavior, 17, 31–40.CrossRefPubMed

Gonzalez, J. S., Penedo, F. J., Llabre, M. M., Duran, R. E., Antoni, M. H., Schneiderman, N., & Horne, R. (2007). Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence. Annals of Behavioral Medicine, 34, 46–55.CrossRefPubMed

Haberer, J. E., Robbins, G. K., Ybarra, M., Monk, A., Ragland, K., Weiser, S. D., & Bangsberg, D. R. (2011). Real-time electronic adherence monitoring is feasible, comparable to unannounced pill counts, and acceptable. AIDS and Behavior, 16, 375–382.CrossRef

Horne, R. (1999). Patients’ beliefs about treatment: The hidden determinant of treatment outcome? Joural of Psychosomatic Research, 47, 491–495.CrossRef

Horne, R., Chapman, S. C., Parham, R., Freemantle, N., Forbes, A., & Cooper, V. (2013). Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: A meta-analytic review of the necessity-concerns framework. PLoS One, 8, e80633. doi:10.1371/journal.pone.0080633 CrossRefPubMedPubMedCentral

Horne, R., Cooper, V., Gellaitry, G., Date, H. L., & Fisher, M. (2007). Patients’ perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: The utility of the necessity-concerns framework. Journal of Acquired Immune Deficiency Syndromes, 45, 334–341.PubMed

Jonsdottir, H., Friis, S., Horne, R., Pettersen, K. I., Reikvam, A., & Andreassen, O. A. (2009). Beliefs about medications: Measurement and relationship to adherence in patients with severe mental disorders. Acta Psychiatrica Scandavia, 119, 78–84.CrossRef

Kalichman, S., Amaral, C. M., Cherry, C., Flanagan, J. A., Pope, H., Eaton, L., & Schinazi, R. (2008). Monitoring Antiretroviral adherence by unannounced pill counts conducted by telephone: Reliability and criterion-related validity. HIV Clinical Trials, 9, 298–308.CrossRefPubMedPubMedCentral

Kalichman, S. C., Amaral, C., Swetsze, C., Eaton, L., Kalichman, M. O., Cherry, C., & Schinazi, R. F. (2010). Monthly unannounced pill counts for monitoring HIV treatment adherence: Tests for self-monitoring and reactivity effects. HIV Clinical Trials, 11, 325–331.CrossRefPubMed

Kalichman, S., Eaton, L., Kalichman, M., & Cherry, C. (2015). Medication beliefs mediate the association between medical mistrst and antiretroviral adherence among African-Americans living with HIV. Journal of Health Psychology. doi:10.1177/1359105315600239.

Kalichman, S. C., Kalichman, M. O., Cherry, C., Swetzes, C., Amaral, C. M., White, D., & Eaton, L. (2011). Brief behavioral self-regulation counseling for HIV treatment adherence delivered by cell phone: An initial test of concept trial. AIDS Patient Care STDs, 25, 303–310.CrossRefPubMedPubMedCentral

Kalichman, S., Rompa, D., & Cage, M. (2000). Distinguishing between overlapping somatic symptoms of depression and HIV disease in people living with HIV–AIDS. Journal of Nervous and Mental Disicions, 188, 662–670.CrossRef

Lima, V. D., Bangsberg, D. R., Harrigan, P. R., Deeks, S. G., Yip, B., Hogg, R. S., & Montaner, J. S. (2010). Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. Journal of Acquired Immune Deficiency Syndromes, 55, 460–465.CrossRefPubMedPubMedCentral

Maulsby, C., Millett, G., Lindsey, K., Kelley, R., Johnson, K., Montoya, D., & Holtgrave, D. (2014). HIV among Black men who have sex with men (MSM) in the United States: A review of the literature. AIDS and Behavior, 18, 10–25.CrossRefPubMed

McFall, A. M., Dowdy, D. W., Zelaya, C. E., Murphy, K., Wilson, T. E., Young, M. A., & Althoff, K. N. (2013). Understanding the disparity: Predictors of virologic failure in women using highly active antiretroviral therapy vary by race and/or ethnicity. Journal of Acquired Immune Deficiency Syndromes, 64, 289–298.CrossRefPubMed

Morrison-Beedy, D., Carey, M. P., & Tu, X. (2006). Accuracy of audio computer-assisted self-interviewing (ACASI) and self-administered questionnaires for the assessment of sexual behavior. AIDS and Behavior, 10, 541–552.CrossRefPubMedPubMedCentral

Nozaki, I., Kuriyama, M., Manyepa, P., Zyambo, M. K., Kakimoto, K., & Barnighausen, T. (2013). False beliefs about ART effectiveness, side effects and the consequences of non-retention and non-adherence among ART patients in Livingstone, Zambia. AIDS and Behavior, 17, 122–126.CrossRefPubMed

Parienti, J. J., Barrail-Tran, A., Duval, X., Nembot, G., Descamps, D., Vigan, M., & Goujard, C. (2013). Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial. Antimicrobial Agents and Chemotherapy, 57, 2265–2271.CrossRefPubMedPubMedCentral

Pellowski, J. A., Kalichman, S. C., & Finitsis, D. J. (2015). Reliability and validity of a single-item rating scale to monitor medication adherence for people living with HIV and lower health literacy. HIV Clinical Trials, 16, 1–9.CrossRefPubMed

Pellowski, J. A., Kalichman, S. C., Matthews, K. A., & Adler, N. (2013). A pandemic of the poor: Social disadvantage and the U.S. HIV epidemic. American Psychologist, 68, 197–209.CrossRefPubMedPubMedCentral

Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. [Research Support, N.I.H., Extramural]. Behavior Research Methods, 40, 879–891.CrossRefPubMed

Reynolds, N. R., Testa, M. A., Su, M., Chesney, M. A., Neidig, J. L., Frank, I., & Robbins, G. K. (2008). Telephone support to improve antiretroviral medication adherence: A multisite, randomized controlled trial. Journal of Acquired Immune Deficiency Syndromes, 47, 62–68.CrossRefPubMed

Saha, S., Jacobs, E. A., Moore, R. D., & Beach, M. C. (2010). Trust in physicians and racial disparities in HIV care. AIDS Patient Care STDs, 24, 415–420.CrossRefPubMedPubMedCentral

Shelton, R. C., Winkel, G., Davis, S. N., Roberts, N., Valdimarsdottir, H., Hall, S. J., & Thompson, H. S. (2010). Validation of the group-based medical mistrust scale among urban black men. Journal of General Internal Medicine, 25, 549–555.CrossRefPubMedPubMedCentral

Siddiqi, A. E., Hu, X., & Hall, H. I. (2015). Mortality among blacks or African Americans with HIV infection: United States, 2008–2012. Morbidity and Mortality Weekly Report, 64, 81–86.PubMed

Simoni, J. M., Huh, D., Wilson, I. B., Shen, J., Goggin, K., Reynolds, N. R., & Liu, H. (2012). Racial/ethnic disparities in ART adherence in the United States: Findings from the MACH14 study. Journal of Acquired Immune Deficiency Syndromes, 60, 466–472.CrossRefPubMedPubMedCentral

Titel: Race-based medical mistrust, medication beliefs and HIV treatment adherence: test of a mediation model in people living with HIV/AIDS
Auteurs: Seth C. Kalichman
Lisa Eaton
Moira O. Kalichman
Tama Grebler
Cynthia Merely
Brandi Welles
Publicatiedatum: 09-07-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-016-9767-1

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 6/2016

Modified social learning theory re-examined: correlates of self-management behaviors of persons with Type 2 diabetes

A dyadic multiple mediation model of patient and spouse stressors predicting patient dietary and exercise adherence via depression symptoms and diabetes self-efficacy

Treatment adherence and illness self-management: introduction to the special issue

Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis

The Common-Sense Model of Self-Regulation (CSM): a dynamic framework for understanding illness self-management

Predictors of medication adherence: fact or artifact