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13-02-2023

Quantifying health-related quality of life in Malaysian type 2 diabetes: focusing on complication types and severity

Auteurs: Michelle Hwee Pheng Tan, Siew Chin Ong, Annushiah Vasan Thakumar, Norlaila Mustafa

Gepubliceerd in: Quality of Life Research | Uitgave 7/2023

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Abstract

Purpose

There is a knowledge gap of health utility values for Type 2 Diabetes Mellitus (T2DM) complications in Malaysia. This study aimed to estimate EQ-5D-5L utility values and evaluate health-related quality of life (HRQoL) for Malaysian T2DM associated with complications and clinical characteristics.

Methods

A cross-sectional study was conducted on T2DM patients at a tertiary hospital outpatient using the Malay and English version of the EQ-5D-5L questionnaire. Health utility values were derived using the Malaysian EQ-5D-5L value set. Ordinary least squares (OLS) multivariable regression model was used to estimate the health utility decrements associated with T2DM-related complications and clinical characteristics.

Results

A total of 513 T2DM patients were recruited. Overall, pain was the most affected of all five EQ-5D-5L dimensions. Patients with foot ulcer, amputation, severe heart failure and frequent hypoglycemia reported more problems collectively in all EQ-5D-5L dimensions. Older age, lower education level, longer duration of T2DM, urine protein creatine index (UPCI) > 0.02 g/mmol, and injection therapy were significantly associated with lower EQ-5D-5L utility values (p < 0.004, Bonferroni adjusted). The lowest unadjusted utility values were reported for severe heart failure 0.65 (interquartile range, IQR 0.50), frequent hypoglycemia 0.74 (0.22) and being amputated 0.78 (0.47). In the multivariable regression model after controlling for sociodemographic and clinical characteristics, the largest utility value decrement was observed for amputation (− 0.158, SE 0.087, p = 0.05), frequent hypoglycemia (− 0.101, SE 0.030, p = 0.001), myocardial infarction (-0.050, SE 0.022, p = 0.022) and obesity (-0.034, SE 0.016, p = 0.029).

Conclusion

Larger utility value decrements were found for severe stages of complications. These findings suggest the value of defining severity of complications in utility elicitation studies. The utility decrement quantified for different T2DM complication severity will be useful for economic evaluations within diabetic-related fields.
Literatuur
4.
go back to reference Ganasegeran, K., Hor, C. P., Jamil, M. F. A., Loh, H. C., Noor, J. M., Hamid, N. A., Suppiah, P. D., Abdul Manaf, M. R., Ch’ng, A. S. H., & Looi, I. (2020). A systematic review of the economic burden of type 2 diabetes in Malaysia. International Journal of Enviromental Research Public Health. https://doi.org/10.3390/ijerph17165723CrossRef Ganasegeran, K., Hor, C. P., Jamil, M. F. A., Loh, H. C., Noor, J. M., Hamid, N. A., Suppiah, P. D., Abdul Manaf, M. R., Ch’ng, A. S. H., & Looi, I. (2020). A systematic review of the economic burden of type 2 diabetes in Malaysia. International Journal of Enviromental Research Public Health. https://​doi.​org/​10.​3390/​ijerph17165723CrossRef
5.
go back to reference Arnold, R. J. G. (2021). Pharmacoeconomics_ From Theory to Practice (2nd ed.). Arnold, R. J. G. (2021). Pharmacoeconomics_ From Theory to Practice (2nd ed.).
8.
go back to reference Devlin, N. J. (2020). EQ5D Methods For Analysing And Reporting. Devlin, N. J. (2020). EQ5D Methods For Analysing And Reporting.
10.
go back to reference Jiao, F. F., Wong, C. K. H., Gangwani, R., Tan, K. C. B., Tang, S. C. W., & Lam, C. L. K. (2017). Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-017-0699-4CrossRefPubMedPubMedCentral Jiao, F. F., Wong, C. K. H., Gangwani, R., Tan, K. C. B., Tang, S. C. W., & Lam, C. L. K. (2017). Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications. Health and Quality of Life Outcomes. https://​doi.​org/​10.​1186/​s12955-017-0699-4CrossRefPubMedPubMedCentral
11.
go back to reference Takahara, M., Katakami, N., Shiraiwa, T., Abe, K., Ayame, H., Ishimaru, Y., Iwamoto, M., Shimizu, M., Tomonaga, O., Yokoyama, H., Matsuoka, T. A., & Shimomura, I. (2019). Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L. Acta Diabetologica, 56(3), 309–319. https://doi.org/10.1007/s00592-018-1244-6CrossRefPubMed Takahara, M., Katakami, N., Shiraiwa, T., Abe, K., Ayame, H., Ishimaru, Y., Iwamoto, M., Shimizu, M., Tomonaga, O., Yokoyama, H., Matsuoka, T. A., & Shimomura, I. (2019). Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L. Acta Diabetologica, 56(3), 309–319. https://​doi.​org/​10.​1007/​s00592-018-1244-6CrossRefPubMed
14.
21.
go back to reference Yang, Z., Purba, F. D., Shafie, A. A., Igarashi, A., Wong, E. L., Lam, H., Van Minh, H., Lin, H. W., Ahn, J., Pattanaphesaj, J., Jo, M. W., Mai, V. Q., Busschbach, J., Luo, N., & Jiang, J. (2022). Do health preferences differ among Asian populations? A comparison of EQ-5D-5L discrete choice experiments data from 11 Asian studies. Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. https://doi.org/10.1007/S11136-021-03075-XCrossRefPubMed Yang, Z., Purba, F. D., Shafie, A. A., Igarashi, A., Wong, E. L., Lam, H., Van Minh, H., Lin, H. W., Ahn, J., Pattanaphesaj, J., Jo, M. W., Mai, V. Q., Busschbach, J., Luo, N., & Jiang, J. (2022). Do health preferences differ among Asian populations? A comparison of EQ-5D-5L discrete choice experiments data from 11 Asian studies. Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. https://​doi.​org/​10.​1007/​S11136-021-03075-XCrossRefPubMed
25.
go back to reference (2019) Clinical Practice Guideline Management Of T2DM 6th Edition. Ministry of Health Malaysia (Vol. 53). (2019) Clinical Practice Guideline Management Of T2DM 6th Edition. Ministry of Health Malaysia (Vol. 53).
27.
go back to reference National Institute for Health and Care Excellence [NICE]. (2022). National Institute for Health and Care Excellence [NICE]. (2022).
28.
go back to reference Pallant, J. (2022). SPSS Survival Manual: A Step by Step Guide to Data Analysis Using IBM SPSS (7th edn). Pallant, J. (2022). SPSS Survival Manual: A Step by Step Guide to Data Analysis Using IBM SPSS (7th edn).
31.
go back to reference Luk, A. O.-Y., Zhang, Y., Ko, G. T. C., Brown, N., Ozaki, R., Tong, P. C. Y., … Chan, J. C. (2014). Health-Related Quality of Life in Chinese Patients with Type 2 Diabetes: An Analysis of the Joint Asia Diabetes Evaluation (JADE) Program. Journal of diabetes & metabolism, 5, 1–7. Luk, A. O.-Y., Zhang, Y., Ko, G. T. C., Brown, N., Ozaki, R., Tong, P. C. Y., … Chan, J. C. (2014). Health-Related Quality of Life in Chinese Patients with Type 2 Diabetes: An Analysis of the Joint Asia Diabetes Evaluation (JADE) Program. Journal of diabetes & metabolism, 5, 1–7.
34.
go back to reference Sakane, N., Kotani, K., Tsuzaki, K., Nishi, M., Takahashi, K., Murata, T., Yamada, K., Okazaki, K., Yanagisawa, K., Yamada, K., Kuribayashi, N., Totsuka, Y., Hiyoshi, T., Naka, M., Sugimoto, M., Aoki, Y., Waki, M., Furuya, M., & Kitaoka,... Yamamoto T. (2015). Fear of hypoglycemia and its determinants in insulin-treated patients with type 2 diabetes mellitus. Japan Journal of Diabetes Investigation, 6, 567–570. https://doi.org/10.1111/jdi.12340CrossRefPubMed Sakane, N., Kotani, K., Tsuzaki, K., Nishi, M., Takahashi, K., Murata, T., Yamada, K., Okazaki, K., Yanagisawa, K., Yamada, K., Kuribayashi, N., Totsuka, Y., Hiyoshi, T., Naka, M., Sugimoto, M., Aoki, Y., Waki, M., Furuya, M., & Kitaoka,... Yamamoto T. (2015). Fear of hypoglycemia and its determinants in insulin-treated patients with type 2 diabetes mellitus. Japan Journal of Diabetes Investigation, 6, 567–570. https://​doi.​org/​10.​1111/​jdi.​12340CrossRefPubMed
35.
go back to reference Izawa, K. P., Watanabe, S., Omiya, K., Yamada, S., Oka, K., Tamura, M., Samejima, H., Osada, N., & Iijima, S. (2005). Health-related quality of life in relation to different levels of disease severity in patients with chronic heart failure. Journal of Japan Physical Therapy Association. https://doi.org/10.1298/jjpta.8.39CrossRef Izawa, K. P., Watanabe, S., Omiya, K., Yamada, S., Oka, K., Tamura, M., Samejima, H., Osada, N., & Iijima, S. (2005). Health-related quality of life in relation to different levels of disease severity in patients with chronic heart failure. Journal of Japan Physical Therapy Association. https://​doi.​org/​10.​1298/​jjpta.​8.​39CrossRef
38.
40.
47.
go back to reference Arifin, B., Idrus, L. R., van Asselt, A. D. I., Purba, F. D., Perwitasari, D. A., Thobari, J. A., Cao, Q., Krabbe, P. F. M., & Postma, M. J. (2019). Health-related quality of life in Indonesian type 2 diabetes mellitus outpatients measured with the Bahasa version of EQ-5D-5L · Index scores · Type 2 diabetes mellitus · Health-related quality of life · Indonesia. Quality of Life Research, 28, 1179–1190. https://doi.org/10.1007/s11136-019-02105-zCrossRefPubMedPubMedCentral Arifin, B., Idrus, L. R., van Asselt, A. D. I., Purba, F. D., Perwitasari, D. A., Thobari, J. A., Cao, Q., Krabbe, P. F. M., & Postma, M. J. (2019). Health-related quality of life in Indonesian type 2 diabetes mellitus outpatients measured with the Bahasa version of EQ-5D-5L · Index scores · Type 2 diabetes mellitus · Health-related quality of life · Indonesia. Quality of Life Research, 28, 1179–1190. https://​doi.​org/​10.​1007/​s11136-019-02105-zCrossRefPubMedPubMedCentral
48.
go back to reference Wongphan, T., & Bunthamcharoen, K. (2018). Utility weight and quality of life in thai diabetes mellitus patients measured by EQ-5D and Thai DQOL. Journal of Preventive Medicine Association of Thailand, 8(1), 121–135. Wongphan, T., & Bunthamcharoen, K. (2018). Utility weight and quality of life in thai diabetes mellitus patients measured by EQ-5D and Thai DQOL. Journal of Preventive Medicine Association of Thailand, 8(1), 121–135.
51.
go back to reference World Bank. (2019). Health Expenditure per capita. World Bank. (2019). Health Expenditure per capita.
54.
go back to reference Koohi, F., Nedjat, S., Yaseri, M., & Cheraghi, Z. (2017). Quality of life among general populations of different countries in the past 10 years, with a focus on human development index: A Systematic review and meta-analysis. Iranian Journal of Public Health, 46(1), 12.PubMedPubMedCentral Koohi, F., Nedjat, S., Yaseri, M., & Cheraghi, Z. (2017). Quality of life among general populations of different countries in the past 10 years, with a focus on human development index: A Systematic review and meta-analysis. Iranian Journal of Public Health, 46(1), 12.PubMedPubMedCentral
56.
go back to reference Quah, J. H., Luo, N., Ng, W. Y., How, C. H., & Tay, E. G. (2011). Health-related quality of life is associated with diabetic complications, but not with short-term diabetic control in primary care. Annals of the Academy of Medicine Singapore, 40(6), 276–286.CrossRefPubMed Quah, J. H., Luo, N., Ng, W. Y., How, C. H., & Tay, E. G. (2011). Health-related quality of life is associated with diabetic complications, but not with short-term diabetic control in primary care. Annals of the Academy of Medicine Singapore, 40(6), 276–286.CrossRefPubMed
65.
go back to reference Sullivan, M. D., Anderson, R. T., Aron, D., Atkinson, H. H., Bastien, A., Chen, G. J., Feeney, P., Gafni, A., Hwang, W., Katz, L. A., Narayan, K. M., Nwachuku, C., O’Connor, P. J., & Zhang, P. (2007). Health-related quality of life and cost-effectiveness components of the action to control cardiovascular risk in diabetes (ACCORD) trial: Rationale and design. American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2007.03.027CrossRefPubMed Sullivan, M. D., Anderson, R. T., Aron, D., Atkinson, H. H., Bastien, A., Chen, G. J., Feeney, P., Gafni, A., Hwang, W., Katz, L. A., Narayan, K. M., Nwachuku, C., O’Connor, P. J., & Zhang, P. (2007). Health-related quality of life and cost-effectiveness components of the action to control cardiovascular risk in diabetes (ACCORD) trial: Rationale and design. American Journal of Cardiology. https://​doi.​org/​10.​1016/​j.​amjcard.​2007.​03.​027CrossRefPubMed
66.
go back to reference Kiadaliri, A. A., Gerdtham, U. G., Eliasson, B., Gudbjornsdottir, S., Svensson, A. M., Carlsson, K. S., & Wordsworth, S. (2017). Health utilities of type 2 diabetes-Related complications: A cross-sectional study in Sweden. Health and Quality of Life Outcomes, 11, 4939–4952. https://doi.org/10.3390/ijerph110504939CrossRef Kiadaliri, A. A., Gerdtham, U. G., Eliasson, B., Gudbjornsdottir, S., Svensson, A. M., Carlsson, K. S., & Wordsworth, S. (2017). Health utilities of type 2 diabetes-Related complications: A cross-sectional study in Sweden. Health and Quality of Life Outcomes, 11, 4939–4952. https://​doi.​org/​10.​3390/​ijerph110504939CrossRef
71.
go back to reference Fidler, C., Elmelund Christensen, T., Gillard, S., Nordisk, N. A., & Samantha Gillard, D. (2011). Hypoglycemia: An overview of fear of hypoglycemia, quality-of-life, and impact on costs Review Hypoglycemia: An overview of fear of hypoglycemia, quality-of-life, and impact on costs Torsten Elmelund Christensen. Journal of Medical Economics, 14(5), 646–655. https://doi.org/10.3111/13696998.2011.610852CrossRefPubMed Fidler, C., Elmelund Christensen, T., Gillard, S., Nordisk, N. A., & Samantha Gillard, D. (2011). Hypoglycemia: An overview of fear of hypoglycemia, quality-of-life, and impact on costs Review Hypoglycemia: An overview of fear of hypoglycemia, quality-of-life, and impact on costs Torsten Elmelund Christensen. Journal of Medical Economics, 14(5), 646–655. https://​doi.​org/​10.​3111/​13696998.​2011.​610852CrossRefPubMed
Metagegevens
Titel
Quantifying health-related quality of life in Malaysian type 2 diabetes: focusing on complication types and severity
Auteurs
Michelle Hwee Pheng Tan
Siew Chin Ong
Annushiah Vasan Thakumar
Norlaila Mustafa
Publicatiedatum
13-02-2023
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 7/2023
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-023-03360-x