Swipe om te navigeren naar een ander artikel
Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient’s perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and (3) identify predictors of HRQOL post-BPM.
We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched.
The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post-BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post-BPM.
There is a paucity of high-quality data on outcomes of different HRQOL domains post-BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Antoniou, A., Pharoah, P. D., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., et al. (2003). Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies. American Journal of Human Genetics, 72(5), 1117–1130. CrossRefPubMedPubMedCentral
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Journal of Clinical Epidemiology, 62(10), e1–34. CrossRefPubMed
Contant, C. M. E., van Wersch, A. M. E., Menke-Pluymers, M. B. E., Wai, R. T. J., Eggermont, A. M. M., & Van Geel, A. N. (2004). Satisfaction and prosthesis related complaints in women with immediate breast reconstruction following prophylactic and oncological mastectomy. Psychology, Health and Medicine, 9(1), 71–84. CrossRef
Brandberg, Y., Sandelin, K., Erikson, S., Jurell, G., Liljegren, A., Lindblom, A., et al. (2008). Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: A prospective 1-year follow-up study. Journal of Clinical Oncology, 26(24), 3943–3949. CrossRefPubMed
Isern, A. E., Tengrup, I., Loman, N., Olsson, H., & Ringberg, A. (2008). Aesthetic outcome, patient satisfaction, and health-related quality of life in women at high risk undergoing prophylactic mastectomy and immediate breast reconstruction. Journal of Plastic and Reconstructive Aesthetic Surgery, 61(10), 1177–1187. CrossRef
Gahm, J., Jurell, G., Edsander-Nord, A., & Wickman, M. (2010). Patient satisfaction with aesthetic outcome after bilateral prophylactic mastectomy and immediate reconstruction with implants. Journal of Plastic and Reconstructive Aesthetic Surgery, 63(2), 332–338. CrossRef
Gahm, J., Edsander-Nord, A., Jurell, G., & Wickman, M. (2010). No differences in aesthetic outcome or patient satisfaction between anatomically shaped and round expandable implants in bilateral breast reconstructions: A randomized study. Plastic and Reconstructive Surgery, 126(5), 1419–1427. CrossRefPubMed
Brandberg, Y., Arver, B., Johansson, H., Wickman, M., Sandelin, K., & Liljegren, A. (2012). Less correspondence between expectations before and cosmetic results after risk-reducing mastectomy in women who are mutation carriers: A prospective study. European Journal of Surgical Oncology, 38(1), 38–43. CrossRefPubMed
Eltahir, Y., Werners, L. L., Dreise, M. M., van Emmichoven, I. A., Jansen, L., Werker, P. M., et al. (2013). Quality-of-life outcomes between mastectomy alone and breast reconstruction: Comparison of patient-reported BREAST-Q and other health-related quality-of-life measures. Plastic and Reconstructive Surgery, 132(2), 201e–209e. CrossRefPubMed
Gahm, J., Hansson, P., Brandberg, Y., & Wickman, M. (2013). Breast sensibility after bilateral risk-reducing mastectomy and immediate breast reconstruction: A prospective study. Journal of Plastic and Reconstructive Aesthetic Surgery, 66(11), 1521–1527. CrossRef
- Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes
Shantanu N. Razdan
Colleen M. McCarthy
- Springer International Publishing