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Journal of Youth and Adolescence
Gepubliceerd in: Journal of Youth and Adolescence 7/2020

13-08-2019

Pubertal Status and Age are Differentially Associated with Inflammatory Biomarkers in Female and Male Adolescents

Auteurs: Allison Stumper, Daniel P. Moriarity, Christopher L. Coe, Lauren M. Ellman, Lyn Y. Abramson, Lauren B. Alloy

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 7/2020

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Abstract

A better understanding of the maturational correlates of inflammatory activity during adolescence is needed to more appropriately study both normal and abnormal development. Inflammation is the immune system’s first response to infection, injury, or psychological stress, and it has been shown to be elevated in individuals with both physical and psychological conditions. This study examined unique associations between (1) pubertal status and inflammatory biomarkers, and (2) age and inflammatory biomarkers, and whether these relationships differed by sex in a diverse sample of 155 adolescents (54.2% female, 45.8% male; Mage = 16.22) from a northeastern city in the US. A more advanced pubertal status was uniquely associated with lower levels of tumor necrosis factor alpha (TNF-α) and interleukin-8 (IL-8). Chronological age was uniquely associated with lower IL-8 levels. The association between pubertal status and C-reactive protein (CRP) levels differed by sex: more mature females had higher CRP, whereas pubertal status and CRP were not significantly associated in males. These findings highlight an important relation between pubertal development and inflammatory activity during adolescence.
vorige artikel Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use
volgende artikel Disentangling the Effects of Boys’ Pubertal Timing: The Importance of Social Context
Voetnoten
1
Immunomodulatory medication use was not significantly associated with any dependent variables, and therefore, was not included in the models. However, when it was included, the pattern of results remained the same. Similarly, only IL-8 was associated with the diagnosis of a medical condition that could affect inflammation, so only models predicting IL-8 included this variable as a covariate. However, when these cases were excluded, the pattern of results remained the same.
 
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Metagegevens
Titel
Pubertal Status and Age are Differentially Associated with Inflammatory Biomarkers in Female and Male Adolescents
Auteurs
Allison Stumper
Daniel P. Moriarity
Christopher L. Coe
Lauren M. Ellman
Lyn Y. Abramson
Lauren B. Alloy
Publicatiedatum
13-08-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Youth and Adolescence / Uitgave 7/2020
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI
https://doi.org/10.1007/s10964-019-01101-3

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