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30-09-2020

Patient-reported outcomes in survivors of breast cancer one, three, and five years post-diagnosis: a cancer registry-based feasibility study

Auteurs: Anita R. Skandarajah, Karolina Lisy, Andrew Ward, Jim Bishop, Karen Lacey, Bruce Mann, Michael Jefford

Gepubliceerd in: Quality of Life Research | Uitgave 2/2021

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Abstract

Introduction and aims

The burden of treatment toxicities in breast cancer requires longitudinal assessment of patient-centered outcomes. The current study aimed to assess the feasibility of collecting general and breast cancer-specific quality of life (QoL), ongoing symptoms and unmet needs, in patients identified from a population-based cancer registry, and to assess the contribution of demographic, disease, and care-related factors.

Methods

Eligible patients were identified from the Victorian Cancer Registry (Victoria, Australia) using the ICD-10 code C50, diagnosed during 2013, 2011, and 2009. Data included age, area of residence, cancer diagnosis, date of diagnosis, treatment modality, and staging. Patients completed a number of validated tools including the EQ-5D-5L and FACT-B, symptom items, and unmet needs.

Results

Of 1006 eligible patients, the overall response rate was 45.6%. Survivors 1 year post-diagnosis had significantly greater problems with pain or discomfort (59.2%) and with anxiety or depression (51.3%) compared with survivors 5 years post-diagnosis (45.1% with pain or discomfort, p < 0.05, and 32.7% with anxiety or depression, p < 0.01). For the 5 years group, pain or discomfort and anxiety or depression were significantly higher than for the general population (32.2% and 21.6%, respectively). Improved quality of life was found in those who did not receive chemotherapy (coefficient = 0.2269, p = 0.0409) and those who did not have a longstanding health condition (coefficient = 0.6342, p < 0.001). Poorer quality of life was associated with those who were not certain what was happening with their breast cancer (coefficient = − 0.3674, p = 0.0094) and those whose cancer had not been treated, had been treated but was still present, or had returned after treatment (coefficient = − 0.5314, p = 0.0136). Across the total cohort, women were bothered by changes in weight (21.3%) and concerned about the effects of stress on their cancer (19.6%). Fear of cancer recurrence was commonly reported and did not diminish over time (60.7%, 52.2%, and 56.9% at 1, 3, and 5 years, respectively).

Conclusion

Collecting patient-reported outcomes from a population-based sample of breast cancer survivors was feasible. Physical symptoms and psychosocial issues are common and are persistent. Use of chemotherapy was the only treatment modality that significantly impacted on QoL.
Literatuur
1.
go back to reference Australian Institute of Health and Welfare. (2017). Cancer in Australia 2017. Cancer series no.101. Cat. no. CAN 100. Canberra: AIHW. Australian Institute of Health and Welfare. (2017). Cancer in Australia 2017. Cancer series no.101. Cat. no. CAN 100. Canberra: AIHW.
3.
go back to reference Ong, W. L., Schouwenburg, M. G., van Bommel, A. C. M., Stowell, C., Allison, K. H., Benn, K. E., et al. (2017). A standard set of value-based patient-centered outcomes for breast cancer: The international consortium for health outcomes measurement (ICHOM) initiative. JAMA Oncology,3(5), 677–685.CrossRef Ong, W. L., Schouwenburg, M. G., van Bommel, A. C. M., Stowell, C., Allison, K. H., Benn, K. E., et al. (2017). A standard set of value-based patient-centered outcomes for breast cancer: The international consortium for health outcomes measurement (ICHOM) initiative. JAMA Oncology,3(5), 677–685.CrossRef
4.
go back to reference Lipscomb, J., Gotay, C. C., & Snyder, C. F. (2007). Patient-reported outcomes in cancer: A review of recent research and policy initiatives. CA: A Cancer Journal for Clinicians,57(5), 278–300. Lipscomb, J., Gotay, C. C., & Snyder, C. F. (2007). Patient-reported outcomes in cancer: A review of recent research and policy initiatives. CA: A Cancer Journal for Clinicians,57(5), 278–300.
5.
go back to reference Richards, M., Corner, J., & Maher, J. (2011). The national cancer survivorship initiative: New and emerging evidence on the ongoing needs of cancer survivors. British Journal of Cancer,105(Suppl 1), S1–4.CrossRef Richards, M., Corner, J., & Maher, J. (2011). The national cancer survivorship initiative: New and emerging evidence on the ongoing needs of cancer survivors. British Journal of Cancer,105(Suppl 1), S1–4.CrossRef
6.
go back to reference Glaser, A. W., Fraser, L. K., Corner, J., Feltbower, R., Morris, E. J., Hartwell, G., et al. (2013). Patient-reported outcomes of cancer survivors in England 1–5 years after diagnosis: A cross-sectional survey. British Medical Journal Open,3(4), e002317. Glaser, A. W., Fraser, L. K., Corner, J., Feltbower, R., Morris, E. J., Hartwell, G., et al. (2013). Patient-reported outcomes of cancer survivors in England 1–5 years after diagnosis: A cross-sectional survey. British Medical Journal Open,3(4), e002317.
7.
go back to reference Downing, A., Morris, E. J., Richards, M., Corner, J., Wright, P., Sebag-Montefiore, D., et al. (2015). Health-related quality of life after colorectal cancer in England: A patient-reported outcomes study of individuals 12 to 36 months after diagnosis. Journal of Clinical Oncology,33(6), 616–624.CrossRef Downing, A., Morris, E. J., Richards, M., Corner, J., Wright, P., Sebag-Montefiore, D., et al. (2015). Health-related quality of life after colorectal cancer in England: A patient-reported outcomes study of individuals 12 to 36 months after diagnosis. Journal of Clinical Oncology,33(6), 616–624.CrossRef
8.
go back to reference Downing, A., Wright, P., Hounsome, L., Selby, P., Wilding, S., Watson, E., et al. (2019). Quality of life in men living with advanced and localised prostate cancer in the UK: A population-based study. The lancet Oncology,20(3), 436–447.CrossRef Downing, A., Wright, P., Hounsome, L., Selby, P., Wilding, S., Watson, E., et al. (2019). Quality of life in men living with advanced and localised prostate cancer in the UK: A population-based study. The lancet Oncology,20(3), 436–447.CrossRef
9.
go back to reference Carlsson, M., & Hamrin, E. (1996). Measurement of quality of life in women with breast cancer. Development of a Life Satisfaction Questionnaire (LSQ-32) and a comparison with the EORTC QLQ-C30. Quality of Life Research,5(2), 265–274.CrossRef Carlsson, M., & Hamrin, E. (1996). Measurement of quality of life in women with breast cancer. Development of a Life Satisfaction Questionnaire (LSQ-32) and a comparison with the EORTC QLQ-C30. Quality of Life Research,5(2), 265–274.CrossRef
11.
go back to reference Montazeri, A. (2008). Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. Journal of Experimental & Clinical Cancer Research,27(1), 32.CrossRef Montazeri, A. (2008). Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. Journal of Experimental & Clinical Cancer Research,27(1), 32.CrossRef
12.
go back to reference Mols, F., Vingerhoets, A. J., Coebergh, J. W., & van de Poll-Franse, L. V. (2005). Quality of life among long-term breast cancer survivors: A systematic review. European Journal of Cancer,41(17), 2613–2619.CrossRef Mols, F., Vingerhoets, A. J., Coebergh, J. W., & van de Poll-Franse, L. V. (2005). Quality of life among long-term breast cancer survivors: A systematic review. European Journal of Cancer,41(17), 2613–2619.CrossRef
13.
go back to reference Mertz, B. G., Dunn-Henriksen, A. K., Kroman, N., Johansen, C., Andersen, K. G., Andersson, M., et al. (2017). The effects of individually tailored nurse navigation for patients with newly diagnosed breast cancer: A randomized pilot study. Acta Oncologica,56(12), 1682–1689.CrossRef Mertz, B. G., Dunn-Henriksen, A. K., Kroman, N., Johansen, C., Andersen, K. G., Andersson, M., et al. (2017). The effects of individually tailored nurse navigation for patients with newly diagnosed breast cancer: A randomized pilot study. Acta Oncologica,56(12), 1682–1689.CrossRef
14.
go back to reference Centre, S. R. (2012). Dual-Frame Omnibus Survey: Technical and Methodological Summary Report. Centre, S. R. (2012). Dual-Frame Omnibus Survey: Technical and Methodological Summary Report.
16.
go back to reference Viney, R., Norman, R., King, M. T., Cronin, P., Street, D. J., Knox, S., et al. (2011). Time trade-off derived EQ-5D weights for Australia. Value Health,14(6), 928–936.CrossRef Viney, R., Norman, R., King, M. T., Cronin, P., Street, D. J., Knox, S., et al. (2011). Time trade-off derived EQ-5D weights for Australia. Value Health,14(6), 928–936.CrossRef
17.
go back to reference Norman, R., Cronin, P., & Viney, R. (2013). A pilot discrete choice experiment to explore preferences for EQ-5D-5L health states. Applied Health Economics and Health Policy,11(3), 287–298.CrossRef Norman, R., Cronin, P., & Viney, R. (2013). A pilot discrete choice experiment to explore preferences for EQ-5D-5L health states. Applied Health Economics and Health Policy,11(3), 287–298.CrossRef
18.
go back to reference Brady, M. J., Cella, D. F., Mo, F., Bonomi, A. E., Tulsky, D. S., Lloyd, S. R., et al. (1997). Reliability and validity of the functional assessment of cancer therapy-breast quality-of-life instrument. Journal of Clinical Oncology,15(3), 974–986.CrossRef Brady, M. J., Cella, D. F., Mo, F., Bonomi, A. E., Tulsky, D. S., Lloyd, S. R., et al. (1997). Reliability and validity of the functional assessment of cancer therapy-breast quality-of-life instrument. Journal of Clinical Oncology,15(3), 974–986.CrossRef
19.
go back to reference Heeringa, S., West, B. T., & Berglund, P. A. (2010). Applied Survey Data Analysis (1st ed.). Boca Raton, FL: CRC Press, Taylor and Francis Group.CrossRef Heeringa, S., West, B. T., & Berglund, P. A. (2010). Applied Survey Data Analysis (1st ed.). Boca Raton, FL: CRC Press, Taylor and Francis Group.CrossRef
20.
go back to reference Hochberg, Y. (1998). A sharper Bonferroni procedure for multiple tests of significance. Biometrika,75(4), 800–802.CrossRef Hochberg, Y. (1998). A sharper Bonferroni procedure for multiple tests of significance. Biometrika,75(4), 800–802.CrossRef
21.
go back to reference Brown, A. W. W., Kabir, M., Sherman, K. A., Meybodi, F., French, J. R., & Elder, E. B. (2017). Patient reported outcomes of autologous fat grafting after breast cancer surgery. Breast,35, 14–20.CrossRef Brown, A. W. W., Kabir, M., Sherman, K. A., Meybodi, F., French, J. R., & Elder, E. B. (2017). Patient reported outcomes of autologous fat grafting after breast cancer surgery. Breast,35, 14–20.CrossRef
22.
go back to reference Mercieca-Bebber, R., King, M. T., Boxer, M. M., Spillane, A., Winters, Z. E., Butow, P. N., et al. (2017). What quality-of-life issues do women with ductal carcinoma in situ (DCIS) consider important when making treatment decisions? Breast Cancer,24, 720–729.CrossRef Mercieca-Bebber, R., King, M. T., Boxer, M. M., Spillane, A., Winters, Z. E., Butow, P. N., et al. (2017). What quality-of-life issues do women with ductal carcinoma in situ (DCIS) consider important when making treatment decisions? Breast Cancer,24, 720–729.CrossRef
23.
go back to reference Jefford, M., Ward, A. C., Lisy, K., Lacey, K., Emery, J. D., Glaser, A. W., et al. (2017). Patient-reported outcomes in cancer survivors: A population-wide cross-sectional study. Supportive Care in Cancer,25, 3171–3179.CrossRef Jefford, M., Ward, A. C., Lisy, K., Lacey, K., Emery, J. D., Glaser, A. W., et al. (2017). Patient-reported outcomes in cancer survivors: A population-wide cross-sectional study. Supportive Care in Cancer,25, 3171–3179.CrossRef
24.
go back to reference Dindo, D., Demartines, N., & Clavien, P. A. (2004). Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of Surgery,240(2), 205–213.CrossRef Dindo, D., Demartines, N., & Clavien, P. A. (2004). Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of Surgery,240(2), 205–213.CrossRef
26.
go back to reference Sprangers, M. A., Groenvold, M., Arraras, J. I., Franklin, J., te Velde, A., Muller, M., et al. (1996). The European Organization for research and treatment of cancer breast cancer-specific quality-of-life questionnaire module: First results from a three-country field study. Journal of Clinical Oncology,14(10), 2756–2768.CrossRef Sprangers, M. A., Groenvold, M., Arraras, J. I., Franklin, J., te Velde, A., Muller, M., et al. (1996). The European Organization for research and treatment of cancer breast cancer-specific quality-of-life questionnaire module: First results from a three-country field study. Journal of Clinical Oncology,14(10), 2756–2768.CrossRef
27.
go back to reference Pusic, A. L., Klassen, A. F., Scott, A. M., Klok, J. A., Cordeiro, P. G., & Cano, S. J. (2009). Development of a new patient-reported outcome measure for breast surgery: The BREAST-Q. Plastic and Reconstructive Surgery,124(2), 345–353.CrossRef Pusic, A. L., Klassen, A. F., Scott, A. M., Klok, J. A., Cordeiro, P. G., & Cano, S. J. (2009). Development of a new patient-reported outcome measure for breast surgery: The BREAST-Q. Plastic and Reconstructive Surgery,124(2), 345–353.CrossRef
28.
go back to reference Fallowfield, L. J., Leaity, S. K., Howell, A., Benson, S., & Cella, D. (1999). Assessment of quality of life in women undergoing hormonal therapy for breast cancer: Validation of an endocrine symptom subscale for the FACT-B. Breast Cancer Research and Treatment,55(2), 189–199.CrossRef Fallowfield, L. J., Leaity, S. K., Howell, A., Benson, S., & Cella, D. (1999). Assessment of quality of life in women undergoing hormonal therapy for breast cancer: Validation of an endocrine symptom subscale for the FACT-B. Breast Cancer Research and Treatment,55(2), 189–199.CrossRef
Metagegevens
Titel
Patient-reported outcomes in survivors of breast cancer one, three, and five years post-diagnosis: a cancer registry-based feasibility study
Auteurs
Anita R. Skandarajah
Karolina Lisy
Andrew Ward
Jim Bishop
Karen Lacey
Bruce Mann
Michael Jefford
Publicatiedatum
30-09-2020
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02652-w