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01-05-2014 | Uitgave 4/2014

Quality of Life Research 4/2014

Parent-reported cognition of children with cancer and its potential clinical usefulness

Tijdschrift:
Quality of Life Research > Uitgave 4/2014
Auteurs:
Jin-Shei Lai, Frank Zelko, Kevin R. Krull, David Cella, Cindy Nowinski, Peter E. Manley, Stewart Goldman
Belangrijke opmerkingen
Results of this study were presented at the 43rd Congress of the International Society of Paediatric Oncology (SIOP), October 28–30, 2011, Auckland, New Zealand.

Abstract

Purpose

Cognitive dysfunction is a common concern for children with brain tumors (BTs) or those receiving central nervous system (CNS) toxic cancer treatments. Perceived cognitive function (PCF) is an economical screening that may be used to trigger full, formal cognitive testing. We assessed the potential clinical utility of PCF by comparing parent-reported scores for children with cancer with scores from the general US population.

Methods

Children (n = 515; mean age = 13.5 years; 57.0 % male) and one of their parents were recruited from pediatric oncology clinics. Most children (53.3 %) had a diagnosis of CNS tumor with an average time since diagnosis of 5.6 years. PCF was evaluated using the pediatric PCF item bank (pedsPCF), which was developed and normed on a sample drawn from the US general pediatric population. Children also completed computer-based neuropsychological tests. We tested relationships between PCF and clinical variables. Differential item functioning (DIF) was used to evaluate measurement bias between the samples.

Results

No item showed DIF, supporting the use of pedsPCF in the cancer sample. PedsPCF differentiated children with (vs. without) a BT, p < 0.01, and groups defined by years since diagnosis, p < 0.01. It significantly (p < 0.05) correlated with computerized neuropsychological tests in 40 of 60 comparisons. Children with BTs were rated as having worse pedsPCF scores than the norm, regardless of years since diagnosis.

Conclusions

PCF significantly differentiated cancer survivors with various clinical characteristics. It is brief and easy to implement. PCF should be considered for routine care of pediatric cancer survivors.

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