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Journal of Autism and Developmental Disorders

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20-01-2020 | Original Paper

Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive–Compulsive Disorder

Auteurs: Andrew J. D. Crow, Jennica M. Janssen, Kayci L. Vickers, Julia Parish-Morris, Paul J. Moberg, David R. Roalf

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2020

Abstract

Olfactory dysfunction is recognized in neurodevelopmental disorders and may serve as an early indicator of global dysfunction. The present meta-analysis measures olfaction effect sizes in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and obsessive–compulsive disorder (OCD). Meta-analysis included 320 ADHD, 346 ASD, and 208 OCD individuals as compared to 910 controls. Olfactory performance deficits were small-to-moderate and heterogeneous (d = − 0.42, 95% CI = − 0.59 < δ < − 0.25). Meta-analytic results indicate that olfactory dysfunction is evident in individuals with ASD and OCD, with small-to-negligible effects in ADHD. These findings imply olfactory dysfunction is related to clinical phenotype in ASD and OCD, but not ADHD, and warrant inclusion in clinical assessment and evaluation of certain neurodevelopmental disorders.

vorige artikel Autistic Traits Do Not Affect Emotional Face Processing in a General Population Sample

volgende artikel Associations Between Broader Autism Phenotype and Dietary Intake: A Cross-Sectional Study (Japan Environment & Children’s Study)

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Titel: Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive–Compulsive Disorder
Auteurs: Andrew J. D. Crow
Jennica M. Janssen
Kayci L. Vickers
Julia Parish-Morris
Paul J. Moberg
David R. Roalf
Publicatiedatum: 20-01-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04376-9

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